(a.) Incapable of being reversed or turned about or back; incapable of being made to run backward; as, an irreversible engine.
(a.) Incapable of being reversed, recalled, repealed, or annulled; as, an irreversible sentence or decree.
Example Sentences:
(1) The specific limited trypsinolysis of bacteriophage T7 RNA polymerase (T7RP) was performed in the presence of various components of the polymerase reaction and some GTP-analogs--irreversible inhibitors of the enzyme.
(2) At 24 or 48 hours after ischemia, 63Ni, 99TcO4, and 22Na were preferentially concentrated in the damaged striatum and hippocampus, whereas 65Zn, 59Fe, 32PO4, and 147Pm did not accumulate in irreversibly injured tissue.
(3) The illumination of the F1-ATPase complexes with NAB-ADP or NAB-GDP leads to the covalent binding of one nucleotide analogue molecule to the enzyme and to the irreversible inactivation of F1-ATPase.
(4) The inhibition was irreversible, as well as time and concentration dependent, which indicates a suicide-inhibition type of metabolism.
(5) It is unclear if the changes in high-energy phosphates during endotoxin shock cause irreversibility.
(6) These studies indicate that, in three models of acute liver injury, the net influx of calcium across the plasma membrane is increased early in the evolution of the injury before irreversible damage occurs.
(7) The kinetics of association of the radioligand suggested the presence of a rapidly associating, reversible binding site, and a slowly associating, apparently irreversible one.
(8) The high capacity of irreversible synthetic-state, smooth muscle cells to bind and accumulate beta-VLDL in contrast to the relative immunity of contractile cells may be relevant to the genesis of atherosclerosis in the rabbit and possibly also in humans.
(9) In the MVD, all esters appeared to irreversibly block the agonist effect of morphine, but none of the compounds irreversibly antagonized [D-Ala2,D-Leu5]enkephalin to a significant degree.
(10) The coronary vasoconstrictor response produced by ibopamine was inhibited completely by the irreversible alpha-adrenoceptor antagonist, phenoxybenzamine, whereas the response produced by epinine was transformed into relaxation which was inhibited by the beta-adrenoceptor antagonist, propranolol.
(11) It is concluded that vasectomy should no longer be considered an irreversible procedure.
(12) No correlation occurred between specific immunopatterns and irreversible brochopulmonary lesions.
(13) In patients under anti-epileptic therapy it is readily possible for the clinical picture to be concealed, and this may then result in irreversible damage due to the disturbance of metabolism remaining uninfluenced.
(14) When tissue metabolism was irreversibly inhibited by exposure to formaldehyde, hydrogen ion concentration and pCO2 were significantly decreased in the mucosal side of the chamber compared with the viable gall bladder.
(15) More than 20 years ago Olney and his colleagues described the 'Excitotoxic Hypothesis' which postulates that, in addition to its normal function in the healthy brain, glutamate can kill neurons by prolonged, receptor-mediated depolarization resulting in irreversible disturbances in ion homeostasis.
(16) Hypercalcaemia is a common disorder, which frequently requires specific treatment either to control symptoms, or to prevent the development of irreversible organ damage or death.
(17) The kinetics of inactivation of the Mg(2+)-containing enzyme in 8 M-urea at higher temperatures suggest a partially unfolded Mg-A-B* dimer intermediate with 50% activity, followed by irreversible inactivation coincident with the appearance of unfolded monomer.
(18) The rate of the irreversible damage to the reaction center II, caused by exposure of spinach thylakoids to high light was slowed down by anaerobic conditions and by lowering the temperature.
(19) Rheumatoid arthritis, a disease of unknown aetiology, has a multifactorial pathogenesis which may result in irreversible connective tissue destruction and loss of joint function.
(20) Although neither patient exhibited a toxic effect, these levels may be associated with an increased risk of thioridazine-induced irreversible pigmentary retinopathy, cardiac arrhythmias, and tardive dyskinesia.
Run
Definition:
(a.) To be played on the stage a number of successive days or nights; as, the piece ran for six months.
() of Run
(p. p.) of Run
(a.) To move, proceed, advance, pass, go, come, etc., swiftly, smoothly, or with quick action; -- said of things animate or inanimate. Hence, to flow, glide, or roll onward, as a stream, a snake, a wagon, etc.; to move by quicker action than in walking, as a person, a horse, a dog.
(a.) To go swiftly; to pass at a swift pace; to hasten.
(a.) To flee, as from fear or danger.
(a.) To steal off; to depart secretly.
(a.) To contend in a race; hence, to enter into a contest; to become a candidate; as, to run for Congress.
(a.) To pass from one state or condition to another; to come into a certain condition; -- often with in or into; as, to run into evil practices; to run in debt.
(a.) To exert continuous activity; to proceed; as, to run through life; to run in a circle.
(a.) To pass or go quickly in thought or conversation; as, to run from one subject to another.
(a.) To discuss; to continue to think or speak about something; -- with on.
(a.) To make numerous drafts or demands for payment, as upon a bank; -- with on.
(a.) To creep, as serpents.
(a.) To flow, as a liquid; to ascend or descend; to course; as, rivers run to the sea; sap runs up in the spring; her blood ran cold.
(a.) To proceed along a surface; to extend; to spread.
(a.) To become fluid; to melt; to fuse.
(a.) To turn, as a wheel; to revolve on an axis or pivot; as, a wheel runs swiftly round.
(a.) To travel; to make progress; to be moved by mechanical means; to go; as, the steamboat runs regularly to Albany; the train runs to Chicago.
(a.) To extend; to reach; as, the road runs from Philadelphia to New York; the memory of man runneth not to the contrary.
(a.) To go back and forth from place to place; to ply; as, the stage runs between the hotel and the station.
(a.) To make progress; to proceed; to pass.
(a.) To continue in operation; to be kept in action or motion; as, this engine runs night and day; the mill runs six days in the week.
(a.) To have a course or direction; as, a line runs east and west.
(a.) To be in form thus, as a combination of words.
(a.) To be popularly known; to be generally received.
(a.) To have growth or development; as, boys and girls run up rapidly.
(a.) To tend, as to an effect or consequence; to incline.
(a.) To spread and blend together; to unite; as, colors run in washing.
(a.) To have a legal course; to be attached; to continue in force, effect, or operation; to follow; to go in company; as, certain covenants run with the land.
(a.) To continue without falling due; to hold good; as, a note has thirty days to run.
(a.) To discharge pus or other matter; as, an ulcer runs.
(a.) To sail before the wind, in distinction from reaching or sailing closehauled; -- said of vessels.
(a.) Specifically, of a horse: To move rapidly in a gait in which each leg acts in turn as a propeller and a supporter, and in which for an instant all the limbs are gathered in the air under the body.
(a.) To move rapidly by springing steps so that there is an instant in each step when neither foot touches the ground; -- so distinguished from walking in athletic competition.
(v. t.) To cause to run (in the various senses of Run, v. i.); as, to run a horse; to run a stage; to run a machine; to run a rope through a block.
(v. i.) To pursue in thought; to carry in contemplation.
(v. i.) To cause to enter; to thrust; as, to run a sword into or through the body; to run a nail into the foot.
(v. i.) To drive or force; to cause, or permit, to be driven.
(v. i.) To fuse; to shape; to mold; to cast; as, to run bullets, and the like.
(v. i.) To cause to be drawn; to mark out; to indicate; to determine; as, to run a line.
(v. i.) To cause to pass, or evade, offical restrictions; to smuggle; -- said of contraband or dutiable goods.
(v. i.) To go through or accomplish by running; as, to run a race; to run a certain career.
(v. i.) To cause to stand as a candidate for office; to support for office; as, to run some one for Congress.
(v. i.) To encounter or incur, as a danger or risk; as, to run the risk of losing one's life. See To run the chances, below.
(v. i.) To put at hazard; to venture; to risk.
(v. i.) To discharge; to emit; to give forth copiously; to be bathed with; as, the pipe or faucet runs hot water.
(v. i.) To be charged with, or to contain much of, while flowing; as, the rivers ran blood.
(v. i.) To conduct; to manage; to carry on; as, to run a factory or a hotel.
(v. i.) To tease with sarcasms and ridicule.
(v. i.) To sew, as a seam, by passing the needle through material in a continuous line, generally taking a series of stitches on the needle at the same time.
(v. i.) To migrate or move in schools; -- said of fish; esp., to ascend a river in order to spawn.
(n.) The act of running; as, a long run; a good run; a quick run; to go on the run.
(n.) A small stream; a brook; a creek.
(n.) That which runs or flows in the course of a certain operation, or during a certain time; as, a run of must in wine making; the first run of sap in a maple orchard.
(n.) A course; a series; that which continues in a certain course or series; as, a run of good or bad luck.
(n.) State of being current; currency; popularity.
(n.) Continued repetition on the stage; -- said of a play; as, to have a run of a hundred successive nights.
(n.) A continuing urgent demand; especially, a pressure on a bank or treasury for payment of its notes.
(n.) A range or extent of ground for feeding stock; as, a sheep run.
(n.) The aftermost part of a vessel's hull where it narrows toward the stern, under the quarter.
(n.) The distance sailed by a ship; as, a good run; a run of fifty miles.
(n.) A voyage; as, a run to China.
(n.) A pleasure excursion; a trip.
(n.) The horizontal distance to which a drift may be carried, either by license of the proprietor of a mine or by the nature of the formation; also, the direction which a vein of ore or other substance takes.
(n.) A roulade, or series of running tones.
(n.) The greatest degree of swiftness in marching. It is executed upon the same principles as the double-quick, but with greater speed.
(n.) The act of migrating, or ascending a river to spawn; -- said of fish; also, an assemblage or school of fishes which migrate, or ascend a river for the purpose of spawning.
(n.) In baseball, a complete circuit of the bases made by a player, which enables him to score one; in cricket, a passing from one wicket to the other, by which one point is scored; as, a player made three runs; the side went out with two hundred runs.
(n.) A pair or set of millstones.
(a.) Melted, or made from molten material; cast in a mold; as, run butter; run iron or lead.
(a.) Smuggled; as, run goods.
Example Sentences:
(1) They are going to all destinations.” Supplies are running thin and aftershocks have strained nerves in the city.
(2) PMS is more prevalent among women working outside the home, alcoholics, women of high parity, and women with toxemic tendency; it probably runs in families.
(3) It would be fascinating to see if greater local government involvement in running the NHS in places such as Manchester leads over the longer term to a noticeable difference in the financial outlook.
(4) report the complications registered, in particular: lead's displacing 6.2%, run away 0.7%, marked hyperthermya 0.0%, haemorrage 0.4%, wound dehiscence 0.3%, asectic necrosis by decubitus 5%, septic necrosis 0.3%, perforation of the heart 0.2%, pulmonary embolism 0.1%.
(5) In contrast to L2 and L3 in L1 the mid gut runs down in a straight line without any looping.
(6) Community owned and run local businesses are becoming increasingly common.
(7) Large gender differences were found in the correlations between the RAS, CR, run frequency, and run duration with the personality, mood, and locus of control scores.
(8) These major departmental transformations are being run in isolation from each other.
(9) In 2012, 20% of small and medium-sized businesses were either run solely or mostly by women.
(10) Current status of prognosis in clinical, experimental and prophylactic medicine is delineated with formulation of the purposes and feasibility of therapeutic and preventive realization of the disease onset and run prediction.
(11) No one has jobs,” said Annie, 45, who runs a street stall selling fried chicken and rice in the Matongi neighbourhood.
(12) They also said no surplus that built up in the scheme, which runs at a £700m deficit, would be paid to any “sponsor or employer” under any circumstances.
(13) This implementation reduced a formidable task to a relatively routine run.
(14) A dozen peers hold ministerial positions and Westminster officials are expecting them to keep the paperwork to run the country flowing and the ministerial seats warm while their elected colleagues fight for votes.
(15) Failure to develop an adequate resource will be costly in the long run.
(16) Obiang, blaming foreigners for bringing corruption to his country, told people he needed to run the national treasury to prevent others falling into temptation.
(17) She added: “We will continue to act upon the overwhelming majority view of our shareholders.” The vote was the second year running Ryanair had suffered a rebellion on pay.
(18) What shouldn't get lost among the hits, home runs and the intentional and semi-intentional walks is that Ortiz finally seems comfortable with having a leadership role with his team.
(19) The American Red Cross said the aid organisation had already run out of medical supplies, with spokesman Eric Porterfield explaining that the small amount of medical equipment and medical supplies available in Haiti had been distributed.
(20) O'Connell first spotted 14-year-old David Rudisha in 2004, running the 200m sprint at a provincial schools race.