(a.) Incapable of being reversed or turned about or back; incapable of being made to run backward; as, an irreversible engine.
(a.) Incapable of being reversed, recalled, repealed, or annulled; as, an irreversible sentence or decree.
Example Sentences:
(1) The specific limited trypsinolysis of bacteriophage T7 RNA polymerase (T7RP) was performed in the presence of various components of the polymerase reaction and some GTP-analogs--irreversible inhibitors of the enzyme.
(2) At 24 or 48 hours after ischemia, 63Ni, 99TcO4, and 22Na were preferentially concentrated in the damaged striatum and hippocampus, whereas 65Zn, 59Fe, 32PO4, and 147Pm did not accumulate in irreversibly injured tissue.
(3) The illumination of the F1-ATPase complexes with NAB-ADP or NAB-GDP leads to the covalent binding of one nucleotide analogue molecule to the enzyme and to the irreversible inactivation of F1-ATPase.
(4) The inhibition was irreversible, as well as time and concentration dependent, which indicates a suicide-inhibition type of metabolism.
(5) It is unclear if the changes in high-energy phosphates during endotoxin shock cause irreversibility.
(6) These studies indicate that, in three models of acute liver injury, the net influx of calcium across the plasma membrane is increased early in the evolution of the injury before irreversible damage occurs.
(7) The kinetics of association of the radioligand suggested the presence of a rapidly associating, reversible binding site, and a slowly associating, apparently irreversible one.
(8) The high capacity of irreversible synthetic-state, smooth muscle cells to bind and accumulate beta-VLDL in contrast to the relative immunity of contractile cells may be relevant to the genesis of atherosclerosis in the rabbit and possibly also in humans.
(9) In the MVD, all esters appeared to irreversibly block the agonist effect of morphine, but none of the compounds irreversibly antagonized [D-Ala2,D-Leu5]enkephalin to a significant degree.
(10) The coronary vasoconstrictor response produced by ibopamine was inhibited completely by the irreversible alpha-adrenoceptor antagonist, phenoxybenzamine, whereas the response produced by epinine was transformed into relaxation which was inhibited by the beta-adrenoceptor antagonist, propranolol.
(11) It is concluded that vasectomy should no longer be considered an irreversible procedure.
(12) No correlation occurred between specific immunopatterns and irreversible brochopulmonary lesions.
(13) In patients under anti-epileptic therapy it is readily possible for the clinical picture to be concealed, and this may then result in irreversible damage due to the disturbance of metabolism remaining uninfluenced.
(14) When tissue metabolism was irreversibly inhibited by exposure to formaldehyde, hydrogen ion concentration and pCO2 were significantly decreased in the mucosal side of the chamber compared with the viable gall bladder.
(15) More than 20 years ago Olney and his colleagues described the 'Excitotoxic Hypothesis' which postulates that, in addition to its normal function in the healthy brain, glutamate can kill neurons by prolonged, receptor-mediated depolarization resulting in irreversible disturbances in ion homeostasis.
(16) Hypercalcaemia is a common disorder, which frequently requires specific treatment either to control symptoms, or to prevent the development of irreversible organ damage or death.
(17) The kinetics of inactivation of the Mg(2+)-containing enzyme in 8 M-urea at higher temperatures suggest a partially unfolded Mg-A-B* dimer intermediate with 50% activity, followed by irreversible inactivation coincident with the appearance of unfolded monomer.
(18) The rate of the irreversible damage to the reaction center II, caused by exposure of spinach thylakoids to high light was slowed down by anaerobic conditions and by lowering the temperature.
(19) Rheumatoid arthritis, a disease of unknown aetiology, has a multifactorial pathogenesis which may result in irreversible connective tissue destruction and loss of joint function.
(20) Although neither patient exhibited a toxic effect, these levels may be associated with an increased risk of thioridazine-induced irreversible pigmentary retinopathy, cardiac arrhythmias, and tardive dyskinesia.
Turn
Definition:
(n.) Convenience; occasion; purpose; exigence; as, this will not serve his turn.
(n.) Incidental or opportune deed or office; occasional act of kindness or malice; as, to do one an ill turn.
(v. t.) To cause to move upon a center, or as if upon a center; to give circular motion to; to cause to revolve; to cause to move round, either partially, wholly, or repeatedly; to make to change position so as to present other sides in given directions; to make to face otherwise; as, to turn a wheel or a spindle; to turn the body or the head.
(v. t.) To cause to present a different side uppermost or outmost; to make the upper side the lower, or the inside to be the outside of; to reverse the position of; as, to turn a box or a board; to turn a coat.
(v. t.) To give another direction, tendency, or inclination to; to direct otherwise; to deflect; to incline differently; -- used both literally and figuratively; as, to turn the eyes to the heavens; to turn a horse from the road, or a ship from her course; to turn the attention to or from something.
(v. t.) To change from a given use or office; to divert, as to another purpose or end; to transfer; to use or employ; to apply; to devote.
(v. t.) To change the form, quality, aspect, or effect of; to alter; to metamorphose; to convert; to transform; -- often with to or into before the word denoting the effect or product of the change; as, to turn a worm into a winged insect; to turn green to blue; to turn prose into verse; to turn a Whig to a Tory, or a Hindu to a Christian; to turn good to evil, and the like.
(v. t.) To form in a lathe; to shape or fashion (anything) by applying a cutting tool to it while revolving; as, to turn the legs of stools or tables; to turn ivory or metal.
(v. t.) Hence, to give form to; to shape; to mold; to put in proper condition; to adapt.
(v. t.) To translate; to construe; as, to turn the Iliad.
(v. t.) To make acid or sour; to ferment; to curdle, etc.: as, to turn cider or wine; electricity turns milk quickly.
(v. t.) To sicken; to nauseate; as, an emetic turns one's stomach.
(v. i.) To move round; to have a circular motion; to revolve entirely, repeatedly, or partially; to change position, so as to face differently; to whirl or wheel round; as, a wheel turns on its axis; a spindle turns on a pivot; a man turns on his heel.
(v. i.) Hence, to revolve as if upon a point of support; to hinge; to depend; as, the decision turns on a single fact.
(v. i.) To result or terminate; to come about; to eventuate; to issue.
(v. i.) To be deflected; to take a different direction or tendency; to be directed otherwise; to be differently applied; to be transferred; as, to turn from the road.
(v. i.) To be changed, altered, or transformed; to become transmuted; also, to become by a change or changes; to grow; as, wood turns to stone; water turns to ice; one color turns to another; to turn Mohammedan.
(v. i.) To undergo the process of turning on a lathe; as, ivory turns well.
(v. i.) To become acid; to sour; -- said of milk, ale, etc.
(v. i.) To become giddy; -- said of the head or brain.
(v. i.) To be nauseated; -- said of the stomach.
(v. i.) To become inclined in the other direction; -- said of scales.
(v. i.) To change from ebb to flow, or from flow to ebb; -- said of the tide.
(v. i.) To bring down the feet of a child in the womb, in order to facilitate delivery.
(v. i.) To invert a type of the same thickness, as temporary substitute for any sort which is exhausted.
(n.) The act of turning; movement or motion about, or as if about, a center or axis; revolution; as, the turn of a wheel.
(n.) Change of direction, course, or tendency; different order, position, or aspect of affairs; alteration; vicissitude; as, the turn of the tide.
(n.) One of the successive portions of a course, or of a series of occurrences, reckoning from change to change; hence, a winding; a bend; a meander.
(n.) A circuitous walk, or a walk to and fro, ending where it began; a short walk; a stroll.
(n.) Successive course; opportunity enjoyed by alternation with another or with others, or in due order; due chance; alternate or incidental occasion; appropriate time.
(n.) Form; cast; shape; manner; fashion; -- used in a literal or figurative sense; hence, form of expression; mode of signifying; as, the turn of thought; a man of a sprightly turn in conversation.
(n.) A change of condition; especially, a sudden or recurring symptom of illness, as a nervous shock, or fainting spell; as, a bad turn.
(n.) A fall off the ladder at the gallows; a hanging; -- so called from the practice of causing the criminal to stand on a ladder which was turned over, so throwing him off, when the signal was given.
(n.) A round of a rope or cord in order to secure it, as about a pin or a cleat.
(n.) A pit sunk in some part of a drift.
(n.) A court of record, held by the sheriff twice a year in every hundred within his county.
(n.) Monthly courses; menses.
(n.) An embellishment or grace (marked thus, /), commonly consisting of the principal note, or that on which the turn is made, with the note above, and the semitone below, the note above being sounded first, the principal note next, and the semitone below last, the three being performed quickly, as a triplet preceding the marked note. The turn may be inverted so as to begin with the lower note, in which case the sign is either placed on end thus /, or drawn thus /.
Example Sentences:
(1) In January 2011, the Nobel peace prize laureate was admitted to a Johannesburg hospital for what officials initially described as tests but what turned out to be an acute respiratory infection .
(2) These are typically runaway processes in which global temperature rises lead to further releases of CO², which in turn brings about more global warming.
(3) Not only do they give employers no reason to turn them into proper jobs, but mini-jobs offer workers little incentive to work more because then they would have to pay tax.
(4) However, as the plan unravels, Professor Marcus's team turn on one another, with painfully (if painfully funny) results.
(5) Given Australia’s number one position as the worst carbon emitter per capita among major western nations it seems hardly surprising that islanders from Fiji, Samoa, Vanuatu and other small island developing states have been turning to Australia with growing exasperation demanding the country demonstrate an appropriate response and responsibility.
(6) Since the first is balked by the obstacle of deficit reduction, emphasis has turned to the second.
(7) He said: "Monetary policy affects the exchange rate – which in turn can offset or reinforce our exposure to rising import prices.
(8) A second Scottish referendum has turned from a highly probable event into an almost inevitable one.
(9) When reformist industrialist Robert Owen set about creating a new community among the workers in his New Lanark cotton-spinning mills at the turn of the nineteenth century, it was called socialism, not corporate social responsibility.
(10) "Especially at a time when they are turning down voluntary requests and securing the positions of senior managers."
(11) Each L subunit contains 127 residues arranged into 10 beta-strands connected by turns.
(12) Local minima of hand speed evident within segments of continuous motion were associated with turn toward the target.
(13) In just a week her life has been turned upside down.
(14) When asked why the streets of London were not heaving with demonstrators protesting against Russia turning Aleppo into the Guernica of our times, Stop the War replied that it had no wish to add to the “jingoism” politicians were whipping up against plucky little Russia .
(15) Berlin said it was not too late to turn back from the abyss, without proposing any decisions or action.
(16) The C-terminal sequence contains an amphiphilic alpha-helix of four turns which lies on the surface of the beta-barrel.
(17) Two years later, Trump tweeted that “Obama’s motto” was: “If I don’t go on taxpayer funded vacations & constantly fundraise then the terrorists win.” The joke, it turns out, is on Trump.
(18) A new bill, to be published this week with the aim of turning it into law by next month, will allow the government to use Britain's low borrowing rates to guarantee the £40bn in infrastructure projects and £10bn for underwriting housing projects.
(19) He campaigned for a no vote and won handsomely, backed by more than 61%, before performing a striking U-turn on Thursday night, re-tabling the same austerity terms he had campaigned to defeat and which the voters rejected.
(20) Seconds later the camera turns away as what sounds like at least 15 gunshots are fired amid bystanders’ screams.