(a.) Incapable of being reversed or turned about or back; incapable of being made to run backward; as, an irreversible engine.
(a.) Incapable of being reversed, recalled, repealed, or annulled; as, an irreversible sentence or decree.
Example Sentences:
(1) The specific limited trypsinolysis of bacteriophage T7 RNA polymerase (T7RP) was performed in the presence of various components of the polymerase reaction and some GTP-analogs--irreversible inhibitors of the enzyme.
(2) At 24 or 48 hours after ischemia, 63Ni, 99TcO4, and 22Na were preferentially concentrated in the damaged striatum and hippocampus, whereas 65Zn, 59Fe, 32PO4, and 147Pm did not accumulate in irreversibly injured tissue.
(3) The illumination of the F1-ATPase complexes with NAB-ADP or NAB-GDP leads to the covalent binding of one nucleotide analogue molecule to the enzyme and to the irreversible inactivation of F1-ATPase.
(4) The inhibition was irreversible, as well as time and concentration dependent, which indicates a suicide-inhibition type of metabolism.
(5) It is unclear if the changes in high-energy phosphates during endotoxin shock cause irreversibility.
(6) These studies indicate that, in three models of acute liver injury, the net influx of calcium across the plasma membrane is increased early in the evolution of the injury before irreversible damage occurs.
(7) The kinetics of association of the radioligand suggested the presence of a rapidly associating, reversible binding site, and a slowly associating, apparently irreversible one.
(8) The high capacity of irreversible synthetic-state, smooth muscle cells to bind and accumulate beta-VLDL in contrast to the relative immunity of contractile cells may be relevant to the genesis of atherosclerosis in the rabbit and possibly also in humans.
(9) In the MVD, all esters appeared to irreversibly block the agonist effect of morphine, but none of the compounds irreversibly antagonized [D-Ala2,D-Leu5]enkephalin to a significant degree.
(10) The coronary vasoconstrictor response produced by ibopamine was inhibited completely by the irreversible alpha-adrenoceptor antagonist, phenoxybenzamine, whereas the response produced by epinine was transformed into relaxation which was inhibited by the beta-adrenoceptor antagonist, propranolol.
(11) It is concluded that vasectomy should no longer be considered an irreversible procedure.
(12) No correlation occurred between specific immunopatterns and irreversible brochopulmonary lesions.
(13) In patients under anti-epileptic therapy it is readily possible for the clinical picture to be concealed, and this may then result in irreversible damage due to the disturbance of metabolism remaining uninfluenced.
(14) When tissue metabolism was irreversibly inhibited by exposure to formaldehyde, hydrogen ion concentration and pCO2 were significantly decreased in the mucosal side of the chamber compared with the viable gall bladder.
(15) More than 20 years ago Olney and his colleagues described the 'Excitotoxic Hypothesis' which postulates that, in addition to its normal function in the healthy brain, glutamate can kill neurons by prolonged, receptor-mediated depolarization resulting in irreversible disturbances in ion homeostasis.
(16) Hypercalcaemia is a common disorder, which frequently requires specific treatment either to control symptoms, or to prevent the development of irreversible organ damage or death.
(17) The kinetics of inactivation of the Mg(2+)-containing enzyme in 8 M-urea at higher temperatures suggest a partially unfolded Mg-A-B* dimer intermediate with 50% activity, followed by irreversible inactivation coincident with the appearance of unfolded monomer.
(18) The rate of the irreversible damage to the reaction center II, caused by exposure of spinach thylakoids to high light was slowed down by anaerobic conditions and by lowering the temperature.
(19) Rheumatoid arthritis, a disease of unknown aetiology, has a multifactorial pathogenesis which may result in irreversible connective tissue destruction and loss of joint function.
(20) Although neither patient exhibited a toxic effect, these levels may be associated with an increased risk of thioridazine-induced irreversible pigmentary retinopathy, cardiac arrhythmias, and tardive dyskinesia.
Unalterable
Definition:
Example Sentences:
(1) As Nick Bostrom, the head of the Future of Humanity Institute at the University of Oxford and a leading transhumanist thinker puts it, transhumanism "challenges the premise that the human condition is and will remain essentially unalterable".
(2) After suppression of prolactin, statistically signific1nt circadian rhythms in PC and PA have been detected with a moderate decrease of PA concentration, while the PC level remained unalterated.
(3) The following resolutions were adopted:– "That we, a monster meeting of the Orangemen of Newtownards and of the surrounding districts, recognise, with gratitude, the exertions of our brethren in time past, and declare our unalterable determination to stand or fall by the principles of our Order in defence of Her Majesty the Queen and of the British Constitution.
(4) General distrust of genetic methodologies as well as the belief that genic disorders are unalterable appear to be salient factors in explaining the neglect of those areas by social scientists.
(5) Unalterable numerical and alphabetical symbols have been developed to apply a registration number to the animal.
(6) Oxygen consumption is usually considered to be predictable and unalterable at a fixed work intensity.
(7) We conclude that the preliminary diagnosis is frequently sufficiently certain to be unalterable by US.
(8) Who have that hunger for something permanent and unalterable?
(9) Comparison of the spermiograms of unalterably vasectomized men with findings from additional rinsings with physiological saline solution and nitrofurantoin showed that the instillation of the vas deferens leads to a swift, mechanically dependent, emptying of the distal sperm depot.
(10) Most of the toxicity is due to an indirect effect developed with unalterable electrodes in the presence of chlorides in the medium.
(11) He was an open and unsophisticated operator, whose chief characteristic was an unalterable commitment to his cause.
(12) At the beginning of a comprehensive and systematic therapy the panorama X-ray photograph is an unalterable requirement.
(13) If he fails to do this, his features become frozen and unalterable, like the Person, the mask of the classic Greek theatre.
(14) Analysis of the virus specific proteins by polyacrylamide gel electrophoresis revealed that the synthesis of G1 was unalterable, and N was stimulated.
(15) Mental retardation is the major unalterable cause for failure to develop independence; some lesser emotional causes can be modified by encouragement.
(16) In this manner, newly found patients can be treated prophylactically before unalterable morbidity or mortality occurs.
(17) Although intrinsic, unalterable defects occur in the aging immune system and nonspecific host defenses, there are factors that physician and patient can concentrate on to reduce the risk of infection.
(18) This review identifies 10 unalterable, 6 conditionally alterable and 9 treatable characteristics which were found to be associated with an elevated risk.
(19) When the dilemma is unalterable, explaining this insoluble conflict-hives phenomenon to the patient will ameliorate symptoms.
(20) R56865 1 microM reduced the increase in resting tension produced by ouabain 300 microM and left unalterated the inotropic effect evoked by ouabain 3 and 300 microM that was reduced by higher concentrations (3 and 6 microM) of R56865.