(n.) The act of irritating, or exciting, or the state of being irritated; excitement; stimulation, usually of an undue and uncomfortable kind; especially, excitement of anger or passion; provocation; annoyance; anger.
(n.) The act of exciting, or the condition of being excited to action, by stimulation; -- as, the condition of an organ of sense, when its nerve is affected by some external body; esp., the act of exciting muscle fibers to contraction, by artificial stimulation; as, the irritation of a motor nerve by electricity; also, the condition of a muscle and nerve, under such stimulation.
(n.) A condition of morbid excitability or oversensitiveness of an organ or part of the body; a state in which the application of ordinary stimuli produces pain or excessive or vitiated action.
Example Sentences:
(1) Postpartum management is directed toward decreasing vasospasm and central nervous system irritability and maintaining fluid and electrolyte balance.
(2) testosterone, fentanyl, nicotine) may ultimately be administered in this way, important questions pertaining to pharmacology (tolerance), toxicity (irritation, sensitisation) and dose sufficiency (penetration enhancement) remain.
(3) It was shown that the antibiotic had low acute toxicity, did not cumulate and had no skin-irritating effect.
(4) Inhibition of binding of [3H]TPA to the receptor preparation by tigliane and ingenane DTE correlates with irritant activity in vivo, while some daphnane and 1 alpha-alkyldaphnane DTE inhibit binding of [3H]TPA in a less pronounced manner but still are very irritant.
(5) Exposure to irritants was also more common among the asthmatics than the nonasthmatics with similar exposure to organic allergens (P = 0.004).
(6) The purpose of this study was to develop a new model for the induction of chronic irritant contact dermatitis, which would reflect well the conditions of daily practice.
(7) The drug I started taking caused an irritating, chronic cough, which disappeared when I switched to an inexpensive diuretic.
(8) These injections led to epidermal hyperplasia in areas overlying the irritant and the effect was most significant when the irritant was placed in the upper dermis.
(9) Two children required lidocaine therapy for cardiac irritability manifesting as multifocal PVCs and ventricular tachycardia.
(10) In autumn, leaf-heaps composted themselves on sunken patios, and were shovelled up by irritated owners of basement flats.
(11) The dietary fibre intake of 25 patients with the irritable bowel syndrome was assessed by dietary recall over one week for the period before onset of symptoms, at diagnosis and after six months treatment with bran and a fibre-rich diet, and compared with controls matched for age and sex.
(12) A case of epidermoid tumor of the sacral area with S3 root irritation resulting in bladder dysfunction is presented and its possible relationship to spinal puncture is discussed.
(13) The present study did not identify any baseline parameters such as initial prostate volume, peak flow rates, or obstructive or irritative symptom scores that correlated with clinical outcome.
(14) Scores on the "dependent smoking" subscale of the smoking motivation questionnaire correlated significantly with overall withdrawal severity, craving, and increased irritability.
(15) The airways can be affected by inflammation, can be targets of infection, and can respond to chemical irritants with bronchoconstrictive responses.
(16) Some pulp irritation can occur if deep restorations are not placed over a protective film.
(17) MIDAZOLAM IS SUPERIOR TO DIAZEPAM IN CERTAIN WAYS: it has a more rapid onset; produces greater anterograde amnesia, less postoperative drowsiness, less venous irritation and less likelihood of thrombophlebitis development.
(18) Primary invasive adenocarcinoma of the bladder was diagnosed in a fifty-two-year-old male with a two-month history of irritative voiding symptoms.
(19) We studied seventy patients, 23 males and 47 females with irritable bowel syndrome in adolescence aged 13-19 yrs, who visited the department of psychosomatic medicine in Takano Hospital during about six year period of April, 1986-July, 1992.
(20) The study suggested that 1) diabetes and "prediabetes" produce significant changes in levels of chondroitin 4, 6, and dermatan sulfates within alveolar bone, 2) in "prediabetic" animals, interdental bone loss occurs prior to the onset of clinical symptoms and in the absence of local irritating factors, the bone height appears to return to normal levels, and 3) there may be a correlation between alveolar bone height and relative levels of dermatan sulfate.
Obtundent
Definition:
(n.) A substance which sheathes a part, or blunts irritation, usually some bland, oily, or mucilaginous matter; -- nearly the same as demulcent.
Example Sentences:
(1) The thigh and hip manifestations can obscure the primary intra-abdominal process either due to the obvious emphysema or to the obtunded abdominal signs secondary to associated neuropathy.
(2) Results showed the greatest inhibition of noxious stimulus perception with Innovar-Vet, lesser inhibition with ketamine-xylazine and ketamine-diazepam, and the least obtunding of nociception with pentobarbital.
(3) The use of wire stylets to facilitate passage of these tubes has increased the chances of unrecognized tracheal intubations, particularly in obtunded patients.
(4) Characteristic clinical features were present in 19 patients, including a gradual obtundation after the initial hemorrhage in 16 patients and small nonreactive pupils in nine patients (all with a Glasgow Coma Scale score of 7 or less).
(5) Kynurenic acid significantly obtunded these behavioral and physiological effects, particularly when given 60-75 min after the toxic insult.
(6) Addition of adenosine deaminase to fat cells isolated from cold-exposed rats did not normalize the lipolytic activity, suggesting that extracellular adenosine was not responsible for the obtunded lipolysis.
(7) A 59-year-old man was admitted because of frequent vomiting and obtundation in February 1982.
(8) Propofol was more effective than methohexitone at obtunding the hypertensive response to electroconvulsive therapy without causing significant hypotension.
(9) Thus, although low doses of glucocorticoids foster development of the coupling of beta-receptors to cellular transduction mechanisms, higher doses such as those used to stimulate lung function may lastingly obtund adrenergic sensitivity.
(10) Neurologic dysfunction is characterized by lethargy, obtundation, persistent vomiting, agitated delirium, and coma.
(11) The current indications for lavage are obtundation, unprotected airway, seizures, the need for urgent removal, and the tendency to form concretions.
(12) Histoplasmosis in the CNS may produce meningitis, single or multiple brain abscesses, and may present with either a clinical picture of obtundation or a deteriorating space-occupying CNS lesion.
(13) Other variables with strong predictive potential were age (P less than 0.001), the presence of multiple disease states (P less than 0.01), therapy with multiple drugs (P less than 0.01) and acute stroke or obtundation on admission (P less than 0.01).
(14) As projected by this study, scleral heterografts might well be used to obliterate bony undercuts and perhaps to obtund cystic cavities and other major bony defects.
(15) The patient became progressively more obtunded throughout the emergency department stay.
(16) The effects of 3H-epinephrine on the duration of block and on the time course of uptake and efflux of local anesthetic (14C-lidocaine hydrochloride) were determined in the infraorbital nerve of the pentobarbital-obtunded rat.
(17) Contraindications for gastric lavage are similar to those for emesis except that it may be safer to use in obtunded, comatose, or uncooperative patients.
(18) I have described a fatal case of GGS meningitis and endocarditis in a previously healthy 84-year-old who had obtundation, irritability, and cellulitis.
(19) The toxicity of dCF alone was minimal, except for one patient who became obtunded on day 5 following the first cycle of therapy.
(20) Symptoms occurred between 30-180 min with the onset of central nervous system depression, ataxia, waxing and waning obtundation, hallucinations, intermittent hysteria or hyperkinetic behavior.