(1) Membranes of this material were filled with islets of Langerhans and implanted in the peritoneal cavity of rats.
(2) After either 5 or 10 days of culture with both cytokines, intense immunofluorescent staining for Ia could be identified on the surface of greater than 80-90% of the viable islet cells.
(3) High mortality, severe destruction of pancreatic B-cells and presence of sporadic mononuclear infiltrations in islets and around excretory ducts were observed.
(4) These and other results suggest that the experimental agents do not provide protection against alloxan inhibition by preventing the entry of alloxan into the intracellular space of the islet.
(5) In attempts to correlate GLUT-1 and GLUT-2 expression to beta-cell function glucose uptake and glucose-stimulated insulin release in fresh and cultured islets were measured.
(6) It is suggested that PDGF is of importance for fetal islet development.
(7) LFD animals (n = 12) do not show any morphometric changes in comparison with LED controls; but macronesia, micronesia and polynesia of islets were observed.
(8) It is concluded that extracellularly generated free radicals induce damage to the plasma membrane of islet cells.
(9) Antibodies in sera from newly diagnosed insulin-dependent diabetes mellitus (IDDM) patients are directed to a human islet cell protein of relative molecular mass (Mr) 64,000.
(10) Both substances decreased the concentrations of NAD(+) in the islet cells to about 10% of the control values within 2h after injection.
(11) Grouped islets treated with actinomycin D and cycloheximide did not exhibit aggregation when incubated with these inhibitors.
(12) Although the islet promoter was found to lack a TATA box, a major transcript from the islet promoter was mapped 486 nucleotides upstream of the translation initiation site.
(13) Six days later, the islets exposed to heat shock showed a lower DNA content, indicating islet cell death.
(14) The results show that the difference in insulin secretory response between islets from normal and pregnant rats may be preserved when the islets are cultured for 20 h, and that these differences are enhanced for a variety of reasons after culture of islets in 83.3 mM glucose.
(15) The hamster islet B cell line HIT retains the ability to secret insulin in response to glucose and several receptor agonists.
(16) On the other hand, the islets in the duodenal lobe were small in size compared with the other 3 regions, and were predominant in insulin and pancreatic polypeptide (PP) cells, but almost lacked in glucagon cells.
(17) These new observations provide insight into the complex nature of GABAergic neurons and beta-cell GABA in regulation of islet function.
(18) Prior treatment with MMSucc in the presence of 2.75 mM glucose sensitized islets to the usually weak insulin secretory effect of 7.5 mM glucose.
(19) The glucose 6-phosphate content of intact islets is higher in the presence of beta- than alpha-D-glucose.
(20) Pancreatic islet cell tumors were induced in 32 of 49 male Wistar rats (73%) surviving 9 months or longer following treatment with streptozotocin alone, with streptozotocin and nicotinamide, or with streptozotocin and picolinamide.
Small
Definition:
(superl.) Having little size, compared with other things of the same kind; little in quantity or degree; diminutive; not large or extended in dimension; not great; not much; inconsiderable; as, a small man; a small river.
(superl.) Being of slight consequence; feeble in influence or importance; unimportant; trivial; insignificant; as, a small fault; a small business.
(superl.) Envincing little worth or ability; not large-minded; -- sometimes, in reproach, paltry; mean.
(superl.) Not prolonged in duration; not extended in time; short; as, after a small space.
(superl.) Weak; slender; fine; gentle; soft; not loud.
(adv.) In or to small extent, quantity, or degree; little; slightly.
(adv.) Not loudly; faintly; timidly.
(n.) The small or slender part of a thing; as, the small of the leg or of the back.
(n.) Smallclothes.
(n.) Same as Little go. See under Little, a.
(v. t.) To make little or less.
Example Sentences:
(1) The effect of insulin-like growth factor I (IGF-I) on growth of small cell lung cancer (SCLC) cell lines was studied.
(2) Such a signal must be due to a small ferromagnetic crystal formed when the nerve is subjected to pressure, such as that due to mechanical injury.
(3) The Na+ ionophore, gramicidin, had a small but significant inhibitory effect on Na(+)-dependent KG uptake, demonstrating that KG uptake was not the result of an intravesicular positive Na+ diffusion potential.
(4) For some time now, public opinion polls have revealed Americans' strong preference to live in comparatively small cities, towns, and rural areas rather than in large cities.
(5) The predicted non-Lorentzian line shapes and widths were found to be in good agreement with experimental results, indicating that the local orientational order (called "packing" by many workers) in the bilayers of small vesicles and in multilamellar membranes is substantially the same.
(6) If Charles Spencer, 3rd Duke of Marlborough, who bought the island in 1738, were to return today he would doubtless recognise the scene, though he might be surprised that his small private buildings have grown into a sizable hotel.
(7) We conclude that chronic emphysema produced in dogs by aerosol administration of papain results in elevated pulmonary artery pressure, which is characterized pathologically by medial hypertrophy of small pulmonary arteries.
(8) As the percentage of rabbit feed is very small compared to the bulk of animal feeds, there is a fair chance that rabbit feed will be contaminated with constituents (additives) of batches previously prepared for other animals.
(9) The extent of the infectious process was limited, however, because the life span of the cultures was not significantly shortened, the yields of infectious virus per immunofluorescent cell were at all times low, and most infected cells contained only a few well-delineated small masses of antigen, suggestive of an abortive infection.
(10) The small units described here could be inhibitory interneurons which convert the excitatory response of large units into inhibition.
(11) Early stabilisation may not ensure normal development but even early splinting carries a small risk of avascular necrosis.
(12) Twenty patients with non-small cell bronchogenic carcinoma were prospectively studied for intrathoracic lymphadenopathy using computed tomography (CT) and magnetic resonance imaging (MRI).
(13) In addition, KM231 could detect a small amount of the antigen ganglioside in human gastric normal and cancerous mucosa and in gastric cancer cell lines by HPTLC-immunostaining.
(14) Two small populations of GLY + neurons were observed outside of the named nuclei of the SOC; one was located dorsal to the LSO, near its dorsal hilus, and the other was identified near the medial pole of the LSO.
(15) Because of the small number of patients reported in the world literature and lack of controlled studies, the treatment of small cell carcinoma of the larynx remains controversial; this retrospective analysis suggests that combination chemotherapy plus radiation offers the best chance for cure.
(16) Only small amounts of 3H oleic acid were converted.
(17) The pH gradient measured with dimethyloxazolidine-2,4-dione and acetylsalicylic acid was very small in both bacteria at a high pH above 8, and was not affected significantly by the addition of CCCP.
(18) The results also indicate that small lesions initially noted only on CT scans of the chest in children with Wilms' tumor frequently represent metastatic tumor.
(19) CT scan revealed a small calcified mass in the right maxillary sinus.
(20) We have previously shown that intratracheally instilled silica (quartz) produces both morphologic evidence of emphysema and small-airway changes, and functional evidence of airflow obstruction.