(n.) The act of passing or flowing out; a moving out from any inclosed place; egress; as, the issue of water from a pipe, of blood from a wound, of air from a bellows, of people from a house.
(n.) The act of sending out, or causing to go forth; delivery; issuance; as, the issue of an order from a commanding officer; the issue of money from a treasury.
(n.) That which passes, flows, or is sent out; the whole quantity sent forth or emitted at one time; as, an issue of bank notes; the daily issue of a newspaper.
(n.) Progeny; a child or children; offspring. In law, sometimes, in a general sense, all persons descended from a common ancestor; all lineal descendants.
(n.) Produce of the earth, or profits of land, tenements, or other property; as, A conveyed to B all his right for a term of years, with all the issues, rents, and profits.
(n.) A discharge of flux, as of blood.
(n.) An artificial ulcer, usually made in the fleshy part of the arm or leg, to produce the secretion and discharge of pus for the relief of some affected part.
(n.) The final outcome or result; upshot; conclusion; event; hence, contest; test; trial.
(n.) A point in debate or controversy on which the parties take affirmative and negative positions; a presentation of alternatives between which to choose or decide.
(n.) In pleading, a single material point of law or fact depending in the suit, which, being affirmed on the one side and denied on the other, is presented for determination. See General issue, under General, and Feigned issue, under Feigned.
(v. i.) To pass or flow out; to run out, as from any inclosed place.
(v. i.) To go out; to rush out; to sally forth; as, troops issued from the town, and attacked the besiegers.
(v. i.) To proceed, as from a source; as, water issues from springs; light issues from the sun.
(v. i.) To proceed, as progeny; to be derived; to be descended; to spring.
(v. i.) To extend; to pass or open; as, the path issues into the highway.
(v. i.) To be produced as an effect or result; to grow or accrue; to arise; to proceed; as, rents and profits issuing from land, tenements, or a capital stock.
(v. i.) To close; to end; to terminate; to turn out; as, we know not how the cause will issue.
(v. i.) In pleading, to come to a point in fact or law, on which the parties join issue.
(v. t.) To send out; to put into circulation; as, to issue notes from a bank.
(v. t.) To deliver for use; as, to issue provisions.
(v. t.) To send out officially; to deliver by authority; as, to issue an order; to issue a writ.
Example Sentences:
(1) You lot have got real issues to talk about and deal with.
(2) The issue of the Schizophrenia Bulletin is devoted to articles representing this full range of conceptual and empirical work on first-episode psychosis.
(3) I’m not in charge of it but he’s stood up and presented that, and when Jenny, you know, criticised it, or raised some issues about grandparent carers – 3,700 of them he calculated – he said “Let’s sit down”.
(4) Issues such as healthcare and the NHS, food banks, energy and the general cost of living were conspicuous by their absence.
(5) Before issuing the ruling, the judge Shaban El-Shamy read a lengthy series of remarks detailing what he described as a litany of ills committed by the Muslim Brotherhood, including “spreading chaos and seeking to bring down the Egyptian state”.
(6) Critics say he is unelectable as prime minister and will never be able to implement his plans, but he has nonetheless pulled attention back to an issue that many thought had gone away for good.
(7) Much of the current information concerning this issue is from short-term studies.
(8) It is entirely proper for serving judges to set out the arguments in high-profile cases to help public understanding of the legal issues, as long as it is done in an even-handed way.
(9) It has announced a four-stage programme of reforms that will tackle most of these stubborn and longstanding problems, including Cinderella issues such as how energy companies treat their small business customers.
(10) One man has died in storms sweeping across the UK that have brought 100-mile-an-hour winds and led to more than 50 flood warnings being issued with widespread disruption on the road and rail networks in much of southern England and Scotland.
(11) The issue has been raised by an accountant investigating the tax affairs of the duchy – an agricultural, commercial and residential landowner.
(12) They are just literally lying.” In August Microsoft severed its ties, saying Alec’s stance on climate change and several other issues “conflicted directly with Microsoft’s values”.
(13) One is that the issue of whether the World Cup should go ahead in Russia and Qatar still firmly remains on the table.
(14) The data indicate greater legitimacy and openness in discussing holocaust-related issues in the homes of ex-partisans than in the homes of ex-prisoners in concentration camps.
(15) That’s a criticism echoed by Democrats in the Senate, who issued a report earlier this month criticising Republicans for passing sweeping legislation in July to combat addiction , the Comprehensive Addiction and Recovery Act (Cara), but refusing to fund it.
(16) It can feel as though an official opinion has been issued.
(17) The first part of this survey which dealt with equipment for the anterior segment was published in a previous issue of this journal.
(18) Problem definition, the first step in policy development, includes identifying the issues, discussing and framing the issues, analyzing data and resources, and deciding on a problem definition.
(19) Heathrow, likewise, said Gatwick's new runway would not solve the issue of hub capacity.
(20) The deep green people who have an issue with the language of natural capital are actually making the same jump from value to commodification that they state that they don’t want ... They’ve equated one with the other,” he says.
Paradigm
Definition:
(n.) An example; a model; a pattern.
(n.) An example of a conjugation or declension, showing a word in all its different forms of inflection.
(n.) An illustration, as by a parable or fable.
Example Sentences:
(1) Comparisons between predicted and observed results of studies using different coalition paradigms show considerable empirical support for the model.
(2) The hypothesis that the standard acoustic startle habituation paradigm contains the elements of Pavlovian fear conditioning was tested.
(3) We present a paradigm to estimate local affine motion parallax structure from a varying image irradiance pattern.
(4) In the present study, we used a double-labeling paradigm to test that hypothesis.
(5) The results show that centrally administered serotonin, the serotonin precursor, 5-hydroxytryptophan administered with clorgyline, a selective MAO A inhibitor, quipazine, a serotonin receptor agonist, and fluoxetine, a selective inhibitor of neuronal re-uptake of serotonin, attenuated all paradigms of FIA and apomorphine induced potentiation of FIA.
(6) The following oculomotor paradigms were investigated: horizontal and vertical saccades of different sizes (10-80 degrees), smooth pursuit eye movements, optokinetic and vestibular nystagmus.
(7) Testing of CGRP (ICV) in both single bottle conditioned-aversion and differential starvation paradigms was done.
(8) Two other groups were trained in a classical defensive paradigm.
(9) A more current view of science, the Probabilistic paradigm, encourages more complex models, which can be articulated as the more flexible maxims used with insight by the wise clinician.
(10) A sample of 154 randomly selected, full-wave rectified and filtered electromyographic recordings was evaluated using a test-retest paradigm.
(11) We used two experimental paradigms inspired by developmental biology to study how bees obtain information on changing colony needs that results in precocious foraging.
(12) Paradigm relies heavily on social science research and analysis to help companies identify and address the specific barriers and unconscious biases that might be affecting their diversity efforts: things like anonymizing resumes so that employers can’t tell a candidate’s gender or ethnicity, or modifying a salary negotiation process that places women and minorities at a disadvantage.
(13) However, in a double-cue conditioning paradigm in which both command words were presented alone on different trials and reinforced, response latency was longer and puff attenuation poorer among Vs than when the UCS was signaled by a unique cue.
(14) Sixteen patients, 6-15 years old, were tested, using an auditory target selection paradigm.
(15) Mild footshock stress may provide a paradigm for studying both peptidergic modulation of brain dopaminergic neurons and the dynamic regulation of tachykinin and opioid peptide transcription, processing and utilization.
(16) Such characteristics are reminiscent of the behavior of variegating position-effects in Drosophila and the application of this paradigm to human disease phenotypes provides both a mechanism by which differential genome imprinting may be accomplished as well as genetic models that may explain the clinical association of syntenic diseases, the association between tumor progression and specific chromosomal aneuploidy and the unusual inheritance characteristics of many diseases.
(17) Finally, using a newly developed paradigm for examining the composition of regenerating axons by axonal transport, we determined that significant amounts of the 57 kDa neuronal IF protein were conveyed into the regrowing axonal sprouts of DRG neurons.
(18) This modern view of man and his world discards the traditional mechanistic paradigm which has been the focus of Western scientific thought and medicine.
(19) A new experimental paradigm for studying cognitive functions by means of endogenous event-related brain potentials is presented.
(20) A paradigm is provided by the disease phenylketonuria in which the homozygote lacks the enzyme for synthesis of the nonessential amino acid tyrosine.