(1) This enhancer sequence is not strictly cell-type specific since it functions in cell lines of both placental (JEG-3) and pituitary (18-54,SF) origin.
(2) VIP maximally increased the transient expression of CRE alpha CAT and the expression of endogenous hCG-alpha mRNA in JEG-3 cells by 4- and 9-fold, respectively.
(3) This result may be explained by the observation that the JAr cells lacked any detectable glucocorticoid receptor and the receptor levels in cytosol prepared from JEG and BeWo cells were 12% and 2%, respectively, of those measured in HeLa cytosol.
(4) The HLA-6.0 or HLA-E genes may encode the lower molecular mass component on Jeg-3 cells, because these genes express molecules of about 38 kDa and 41 kDa, respectively, when transfected to appropriate host cells.
(5) In order to determine whether RA stimulates the hCG secretion by other trophoblastic cell lines, we evaluated the effect of RA on hCG, hCG-alpha subunit (hCG-alpha), and progesterone secretion in three choriocarcinoma cell lines: JEG-3, JAR, and BeWo.
(6) Reporter genes containing either the intact 1.5 kilobase of 5'-flanking sequence from the HCG alpha gene, or just the 36-bp tandem repeat cAMP response element, when coupled to an enhancerless promoter, both exhibit a vigorous cAMP stimulation of expression but no response to phorbol ester in JEG-3 cells.
(7) We demonstrate the molecular peculiarities of these modified smooth muscle cells using monoclonal antibodies produced against a benign human JEG-cell tumour.
(8) The transcriptional activities of P1 + P2 in their natural tandem orientation were additive in rat keratinocytes and human JEG choriocarcinoma cells.
(9) Using DNase I protection analyses and gel-mobility shift assays, we examined in vitro the domains in the human alpha-gene 5'-flanking sequence that bind nuclear proteins extracted from JEG-3 choriocarcinoma cells.
(10) The effect of JEG-3 choriocarcinoma supernatant on human natural killer cell and lymphokine-activated killer cell activity was investigated.
(11) Similar observations have been made in JeG-3 cells and Chinese hamster ovary cells stably transfected with human apoE cDNA constructs.
(12) In human choriocarcinoma JEG-3 and monkey COS-1 cells, the cytosolic thyroid hormone binding protein is a monomer of the tetrameric pyruvate kinase, subtype M2, which does not bind T3.
(13) In this study the 5'-flanking sequence of the CG beta gene was fused to a sensitive luciferase (LUC) reporter gene, allowing delineation of a CG beta CRE in transient expression assays performed in JEG-3 choriocarcinoma cells.
(14) JEG-3 choriocarcinoma cells demonstrate c-myc transcript levels that are greater than those of nonmalignant trophoblastic tissue at any stage of gestation.
(15) No significant expression of any of these ANG-GH fusion genes over the promoterless pOGH was observed in JEG-3 cells.
(16) Results of these studies suggest that there is some degree of tissue specificity of FN gene expression and reveal that cAMP induction is mediated, in part, by the same element (CRE) in both HT-1080 and JEG-3 cells.
(17) Epidermal growth factor (EGF) binds to JEG-3 cells, a tissue culture line of human choriocarcinoma.
(18) In JEG-3 choriocarcinoma cells the MMTV promoter is transcribed inefficiently, even after transfection of the receptor cDNA and treatment with glucocorticoids or progestins.
(19) A similar increase in Class I antigens is also found in JEG-3 choriocarcinoma cells after treatment with IFN-gamma.
(20) Deletion of the FN promoter from positions -510 to -56 resulted in an ~30-fold decrease in promoter activity when this construction was transfected into HT-1080 cells, and similar results were observed in NIH 3T3 cells; however, less than a 2-fold effect was observed in JEG-3 cells.
Jew
Definition:
(n.) Originally, one belonging to the tribe or kingdom of Judah; after the return from the Babylonish captivity, any member of the new state; a Hebrew; an Israelite.
Example Sentences:
(1) The Nazi extermination of Jews in Lithuania (aided enthusiastically by local Lithuanians) was virtually total.
(2) At its centre was the Holocaust, the industrialised slaughter of 6 million Jews by the Nazis: an attempt at the annihilation of an entire people.
(3) Unlike Baker, a courtly Texan, Lew is a low-key figure, an observant Orthodox Jew and native New Yorker, of whom the New York Times once revealed: "He brings his own lunch (a cheese sandwich and an apple) and eats at his desk."
(4) Dreyfus, an Alsatian Jew, was falsely accused of passing secrets to Germany in 1894 in a well-known historical episode that gave rise to suspicions of antisemitism in the French military establishment of the period.
(5) An additional 200,000 Jews live in settlements in East Jerusalem.
(6) Refusing either to acquiesce in, or to rail at, Eliot's contempt for Jews, one strives to do justice to the many injustices Eliot does to Jews.
(7) Muslim Engagement and Development (MEND), an outfit that previously operated under the banner of iEngage until controversy forced a rebrand , has decided that the worst it can say about Tell MAMA, the best means it can find of turning it into a satanic organisation, is to say that it associates with gays and Jews.
(8) What if the ad vilified African Americans, or Jews, or any other group for which public denigration is less permissible?
(9) The frequency of serum alkaline phospatase phenotypes and secretor trait is determined for Israeli Jews originating from three distinct geographical regions: Eastern and Central Europe (group I), North Africa (group II) and the Middle East (group III).
(10) The poll is the first major survey of the attitudes of British Jews to Israel since 2010.
(11) In what is widely regarded as the greatest crime in human history, around six million Jews were murdered during the second world war.
(12) Jews when they get successful, they will help their people, and some of the African Americans – maybe I'll get in trouble again – they don't want to help anybody," he said.
(13) He told the court: “We have been trying at the bar to imagine whether we can think of any other group of legal or natural persons, terrorist suspects, arms dealers, Jews, in respect of whose evidence one might even begin to think that one could tenably say, ‘Well, of course, in looking at this evidence I have been very careful because I know from the past that these people are a bit devious and a bit unworthy, and the only thing they’re really interested in is subverting public health.’ ” Yet last week’s judgment, running to 1,000 paragraphs, confirmed in excoriating detail just how determined big tobacco has been down the decades to achieve precisely this goal.
(14) A Liberal Democrat MP who likened the atrocities against Palestinians by "the Jews" to the Holocaust has made a public apology in the face of widespread anger.
(15) There should be absolutely no doubt: Hamas’s recent statements celebrating terror attacks are entirely consistent with its charter, which calls for the murder of Jews.
(16) In seven cases it turned out that the passports used were in the name of Jews who had moved to Israel from Britain and Germany and had no knowledge someone using their identity had visited Dubai.
(17) Compared with Catholics and Protestants, Jews had significantly higher rates of major depression and dysthymia, but lower rates of alcohol abuse.
(18) The Jedwabne massacre and Kaminski's line that "Jews should say sorry for killing Poles" during the second world war is by far the most important of the many contentious issues on this man.
(19) The incidence in Ashkenazi Jews originating from eastern and central Europe, was 10 and 20 folds higher than in Sephardic Jews and Arabs respectively.
(20) Many claims made against them echo with uncanny precision those once made against Jews and Catholics.