What's the difference between jervine and nervine?
Jervine
Definition:
(n.) A poisonous alkaloid resembling veratrine, and found with it in white hellebore (Veratrum album); -- called also jervina.
Example Sentences:
(1) It has been demonstrated that jervine, a steroidal alkaloid derived from plants of the genus Veratrum, exerts teratogenic effects in several animal species.
(2) High-pressure liquid chromatography was used to separate the following steroidal alkaloids: tomatidine, solanidine, solasodine, rubijervine, veratramine and jervine.
(3) One strain, Swiss N:GP(S), was retested since a Swiss Webster strain had been found previously to be jervine-resistant.
(4) Jervine, a steroidal alkaloid found as a minor constituent in the teratogenic range plant Veratrum californicum, has produced similar terata in sheep, rabbit, hamster, and chick, although the sensitivity to the alkaloid varies in the different species.
(5) Mature chondrocytes were resistant to jervine but "dedifferentiated" after 48-hour exposure to retinoic acid.
(6) Golden hamster fetuses were extremely sensitive to the teratogenic action of jervine and cyclopamine, the steroidal alkaloid tetratogens from Veratrum californicum.
(7) We conclude that jervine compromises rapidly dividing chondrogenic precursors, whereas retinoic acid has little effect prior to the expression of cartilage-specific proteins.
(8) It is worthy of noting that 1) configuration of the oxygen at the C-17 in hupehenisine 3 is possibly erroneous; 2) both songbaisine 4 (A or B) and peimisine 2 should be the same compound on the basis of comparison of their 13C NMR data (Table 3) and 1H NMR spectra; 3) configuration of the oxygen atom at C-17 in the jervine-type steroidal alkaloids can not be safely proved by their IR, MS and the chemical shifts of some protons such as the methyls without the X-ray diffraction analysis, or the NOE technique and the 13C NMR method.
(9) Prior to differentiation, exposure of limb cell cultures to jervine suppressed subsequent accumulation of cartilage proteoglycans.
(10) Our studies indicate that jervine acts specifically during an early phase of the differentiation of mesenchyme into cartilage.
(11) The aim of this study was to determine the teratogenic potential of jervine in three strains of mice and to ascertain if the response is strain dependent.
(12) Jervine and retinoic acid are both teratogenic to structures which are initially modelled in cartilage.
(13) Sprague-Dawley derived albino rats were susceptible to cyclopamine but not to jervine, and at an incidence very much lower than that of hamsters.
(14) Here we compare the effects of jervine and retinoic acid in three culture systems which represent sequential stages of the chondrocyte lineage.
(15) This strain-dependent difference was observed both in vivo and in vitro, supporting the validity of limb mesenchyme spot cultures as a model for jervine-induced teratogenicity.
Nervine
Definition:
(a.) Having the quality of acting upon or affecting the nerves; quieting nervous excitement.
(n.) A nervine agent.
Example Sentences:
(1) Elevated blood levels confirmed bromide intoxication in both the mother and infant secondary to chronic maternal bromide ingestion (Nervine).