(1) Since the protective protein possesses extensive sequence homology with carboxypeptidase Y (carb Y) and the KEX 1 gene product from yeast, we have used the artificial substrate N-CBZ-Phe-Leu to detect and characterize the peptidase activity of the lysosomal carboxypeptidase (carb L).
(2) To study the molecular mechanisms involved in polyprotein processing, we have transfected the yeast KEX-2 gene into mouse NIH 3T3 fibroblasts and established a new cell line (called 2N-DK) where the KEX-2 endoprotease is permanently expressed.
(3) • Doubles from £117 room-only, Laugavegur 66-68, +354 553 9366, aldahotel.is Kex Hostel Facebook Twitter Pinterest Not only is Kex one of the smartest hostels you’ll come across, it’s also one of the coolest places to hang out in Reykjavik – whether that’s listening to bands playing in the bar (or on the terrace), eating in the superb bar or relaxing in the lounge.
(4) The first-order rates are compared with that of a fourth variant Phe82----Gly which has been measured previously (E0 = 220 mV, kex = 0.7 s-1).
(5) While the mammalian endoproteases responsible for these cleavages are yet to be identified, this function has been unequivocally assigned in yeast to the product of the KEX-2 gene.
(6) The evidence for this cellular location is supported by measurement of intracellular and extracellular KEX-2 enzyme activity.
(7) The apparent pseudo-first-order exchange rate, kex, of the backbone amide protons and the correspondent activation enthalpies, delta H not equal to, were determined.
(8) For all other backbone amide protons in BPTI, the exchange was found to be uncorrelated and by an EX2 mechanism under all conditions of p2H and temperature where quantitative measurements could be obtained with the methods used, i.e., for kex approximately less than 5 min-1.
(9) For three variants of yeast iso-1-cytochrome c the rate constants measured by saturation transfer are wild-type (Asn52, E0 = 270 mV, kex = 0.3 s-1), Asn52----Ala (E0 = 240 mV, kex = 0.6 s-1), Asn52----Ile (E0 = 220 mV, kex = 1.0 s-1).
(10) It was found that the KEX-2 protease was unable to cleave the prepro-Lys-Arg-Pro-IL6 sequence, but that unspecific cleavage of the precursor protein had occurred.
(11) Thus, the kex phenotype does not require an alteration of the killer plasmid.--Kex1 and kex2 strains each contain near-normal levels of the 1.4 x 10(6) molecular weight double-stranded RNA, whose presence is correlated with the presence of the killer genome.
(12) The experimental study showed that KEX-I can inactivate directly the virus of Coxsackie B3, protect the heart cells in mice, prevent attack by Coxsackie B3, promote the growth of internal interferon and increase the NK cell's function to regulate immunity in experimental mice.
(13) When P2 organelles were separated in sucrose density gradients Rho1p comigrated with the Kex-2 activity, a late Golgi marker.
(14) Insulin affected both rate constants, reducing k(in) by 2.8-fold and increasing kex by 3.3-fold.
(15) The rate constants of efficient exchange interaction (kex) of spin-labelled lysozyme and the triplet probes perylene, eosine and anthracene butanoic acid with the haemoproteins were measured in microsomes and in solution by electron paramagnetic resonance and by the registration of delayed annihilation fluorescence.
(16) The look of Kex is, in part, down to Hálfdan Lárus Pedersen, a film production designer.
(17) At pH 6.0, first order rate constants for amino acid exit (kex) under steady state conditions for L-leucine, L-alanine, and L-serine were 1.1-1.3, 0.084, and 0.053 min-1, respectively.
(18) Most significantly, cleavage of the precursor to SRIF-28 was independent of the Kex 2 endoprotease since processing occurred efficiently in a kex 2 mutant strain.
(19) The clinical study was carried out with KEX-I according to a random, paired and cross-over design.
(20) Of particular clinical relevance is the [Cai] response to cardioplegia containing 16 mM [Kex]: neither group demonstrated the expected [Cai] increase in response to potassium depolarization.
Key
Definition:
(n.) An instrument by means of which the bolt of a lock is shot or drawn; usually, a removable metal instrument fitted to the mechanism of a particular lock and operated by turning in its place.
(n.) An instrument which is turned like a key in fastening or adjusting any mechanism; as, a watch key; a bed key, etc.
(n.) That part of an instrument or machine which serves as the means of operating it; as, a telegraph key; the keys of a pianoforte, or of a typewriter.
(n.) A position or condition which affords entrance, control, pr possession, etc.; as, the key of a line of defense; the key of a country; the key of a political situation. Hence, that which serves to unlock, open, discover, or solve something unknown or difficult; as, the key to a riddle; the key to a problem.
(n.) That part of a mechanism which serves to lock up, make fast, or adjust to position.
(n.) A piece of wood used as a wedge.
(n.) The last board of a floor when laid down.
(n.) A keystone.
(n.) That part of the plastering which is forced through between the laths and holds the rest in place.
(n.) A wedge to unite two or more pieces, or adjust their relative position; a cotter; a forelock.
(n.) A bar, pin or wedge, to secure a crank, pulley, coupling, etc., upon a shaft, and prevent relative turning; sometimes holding by friction alone, but more frequently by its resistance to shearing, being usually embedded partly in the shaft and partly in the crank, pulley, etc.
(n.) An indehiscent, one-seeded fruit furnished with a wing, as the fruit of the ash and maple; a samara; -- called also key fruit.
(n.) A family of tones whose regular members are called diatonic tones, and named key tone (or tonic) or one (or eight), mediant or three, dominant or five, subdominant or four, submediant or six, supertonic or two, and subtonic or seven. Chromatic tones are temporary members of a key, under such names as " sharp four," "flat seven," etc. Scales and tunes of every variety are made from the tones of a key.
(n.) The fundamental tone of a movement to which its modulations are referred, and with which it generally begins and ends; keynote.
(n.) Fig: The general pitch or tone of a sentence or utterance.
(v. t.) To fasten or secure firmly; to fasten or tighten with keys or wedges.
Example Sentences:
(1) Community involvement is a key element of the Primary Health Care (PHC) approach, and thus an essential topic on a course for managers of Primary Health Care programmes.
(2) A key way of regaining public trust will be reforming the system of remuneration as agreed by the G20.
(3) Instead, the White House opted for a low-key approach, publishing a blogpost profiling Trinace Edwards, a brain-tumour victim who recently discovered she was eligible for Medicaid coverage.
(4) The presence of a few key residues in the amino-terminal alpha-helix of each ligand is sufficient to confer specificity to the interaction.
(5) The key warning from the Fed chair A summary of Bernanke's hearing Earlier... MPs in London quizzed the Bank of England on Libor.
(6) "Seller reports are key to identifying bad buyers and ridding them from our marketplace," says eBay.
(7) It is suggested that the low-density lipoprotein receptors in human fetal liver may play a key role in the regulation of the serum cholesterol levels during gestation.
(8) A key component of a career program should be recognition of a nurse's needs and the program should be evaluated to determine if these needs are met.
(9) As novel antibody therapeutics are developed for different malignancies and require evaluation with cells previously uncharacterized as antibody-dependent cell-mediated cytotoxicity (ADCC) targets, efficient description of key parameters of the assay system expedites the preclinical assessment.
(10) Meanwhile, Hunt has been accused of backtracking on a key recommendation in the official report into Mid Staffs.
(11) The safe motherhood initiative demands an intersectoral, collaborative approach to gynecology, family planning, and child health in which midwifery is the key element.
(12) Acetylcholinesterase is a key enzyme in cholinergic neurotransmission for hydrolyzing acetylcholine and has been shown to possess arylacylamidase activity in addition to esterase activity.
(13) If Lagarde had been placed under formal investigation in the Tapie case, it would have risked weakening her position and further embarrassing both the IMF and France by heaping more judicial worries on a key figure on the international stage.
(14) Four goals, four assists, and constant movement have been a key part of the team’s success.
(15) Mechanosensitive ion channels may play a key role in transducing vascular smooth muscle (VSM) stretch into active force development.
(16) But Abaaoud, the man thought to be a key planner for the group behind the Paris attacks, boasted to a niece that he had brought around 90 militants back to Europe with him.
(17) Key therapeutic questions are whether beta-lactams can safely replace aminoglycosides for the treatment of gram-negative pneumonia, and whether monotherapy or aminoglycoside and beta-lactam combination antibiotic treatment is superior.
(18) Teaching procedures then establish and build these key components to fluency.
(19) Doubts about Hinkley Point have deepened after a detailed report by HSBC’s energy analysts described eight key challenges to the project, which will be built by the state-backed French firm EDF and be part-financed by investment from China .
(20) The Lords will vote on three key amendments: • To exclude child benefit from the cap calculation (this would roughly halve the number of households affected).