(n.) An instrument by means of which the bolt of a lock is shot or drawn; usually, a removable metal instrument fitted to the mechanism of a particular lock and operated by turning in its place.
(n.) An instrument which is turned like a key in fastening or adjusting any mechanism; as, a watch key; a bed key, etc.
(n.) That part of an instrument or machine which serves as the means of operating it; as, a telegraph key; the keys of a pianoforte, or of a typewriter.
(n.) A position or condition which affords entrance, control, pr possession, etc.; as, the key of a line of defense; the key of a country; the key of a political situation. Hence, that which serves to unlock, open, discover, or solve something unknown or difficult; as, the key to a riddle; the key to a problem.
(n.) That part of a mechanism which serves to lock up, make fast, or adjust to position.
(n.) A piece of wood used as a wedge.
(n.) The last board of a floor when laid down.
(n.) A keystone.
(n.) That part of the plastering which is forced through between the laths and holds the rest in place.
(n.) A wedge to unite two or more pieces, or adjust their relative position; a cotter; a forelock.
(n.) A bar, pin or wedge, to secure a crank, pulley, coupling, etc., upon a shaft, and prevent relative turning; sometimes holding by friction alone, but more frequently by its resistance to shearing, being usually embedded partly in the shaft and partly in the crank, pulley, etc.
(n.) An indehiscent, one-seeded fruit furnished with a wing, as the fruit of the ash and maple; a samara; -- called also key fruit.
(n.) A family of tones whose regular members are called diatonic tones, and named key tone (or tonic) or one (or eight), mediant or three, dominant or five, subdominant or four, submediant or six, supertonic or two, and subtonic or seven. Chromatic tones are temporary members of a key, under such names as " sharp four," "flat seven," etc. Scales and tunes of every variety are made from the tones of a key.
(n.) The fundamental tone of a movement to which its modulations are referred, and with which it generally begins and ends; keynote.
(n.) Fig: The general pitch or tone of a sentence or utterance.
(v. t.) To fasten or secure firmly; to fasten or tighten with keys or wedges.
Example Sentences:
(1) Community involvement is a key element of the Primary Health Care (PHC) approach, and thus an essential topic on a course for managers of Primary Health Care programmes.
(2) A key way of regaining public trust will be reforming the system of remuneration as agreed by the G20.
(3) Instead, the White House opted for a low-key approach, publishing a blogpost profiling Trinace Edwards, a brain-tumour victim who recently discovered she was eligible for Medicaid coverage.
(4) The presence of a few key residues in the amino-terminal alpha-helix of each ligand is sufficient to confer specificity to the interaction.
(5) The key warning from the Fed chair A summary of Bernanke's hearing Earlier... MPs in London quizzed the Bank of England on Libor.
(6) "Seller reports are key to identifying bad buyers and ridding them from our marketplace," says eBay.
(7) It is suggested that the low-density lipoprotein receptors in human fetal liver may play a key role in the regulation of the serum cholesterol levels during gestation.
(8) A key component of a career program should be recognition of a nurse's needs and the program should be evaluated to determine if these needs are met.
(9) As novel antibody therapeutics are developed for different malignancies and require evaluation with cells previously uncharacterized as antibody-dependent cell-mediated cytotoxicity (ADCC) targets, efficient description of key parameters of the assay system expedites the preclinical assessment.
(10) Meanwhile, Hunt has been accused of backtracking on a key recommendation in the official report into Mid Staffs.
(11) The safe motherhood initiative demands an intersectoral, collaborative approach to gynecology, family planning, and child health in which midwifery is the key element.
(12) Acetylcholinesterase is a key enzyme in cholinergic neurotransmission for hydrolyzing acetylcholine and has been shown to possess arylacylamidase activity in addition to esterase activity.
(13) If Lagarde had been placed under formal investigation in the Tapie case, it would have risked weakening her position and further embarrassing both the IMF and France by heaping more judicial worries on a key figure on the international stage.
(14) Four goals, four assists, and constant movement have been a key part of the team’s success.
(15) Mechanosensitive ion channels may play a key role in transducing vascular smooth muscle (VSM) stretch into active force development.
(16) But Abaaoud, the man thought to be a key planner for the group behind the Paris attacks, boasted to a niece that he had brought around 90 militants back to Europe with him.
(17) Key therapeutic questions are whether beta-lactams can safely replace aminoglycosides for the treatment of gram-negative pneumonia, and whether monotherapy or aminoglycoside and beta-lactam combination antibiotic treatment is superior.
(18) Teaching procedures then establish and build these key components to fluency.
(19) Doubts about Hinkley Point have deepened after a detailed report by HSBC’s energy analysts described eight key challenges to the project, which will be built by the state-backed French firm EDF and be part-financed by investment from China .
(20) The Lords will vote on three key amendments: • To exclude child benefit from the cap calculation (this would roughly halve the number of households affected).
Keyhole
Definition:
(n.) A hole or apertupe in a door or lock, for receiving a key.
(n.) A hole or excavation in beams intended to be joined together, to receive the key which fastens them.
(n.) a mortise for a key or cotter.
Example Sentences:
(1) This effect appeared to be related to dose, and was clearly demonstrable with antibody-forming spleen cells from mice that had been immunized either with sheep red blood cells or with penicillin G conjugated with Keyhole limpet hemocyanin.
(2) The control, uninfected rats make vigorous primary and secondary antibody responses when challenged with keyhole limpet haemocyanin (KLH), human immunoglobulin (HuIg) or sheep red blood cells (SRBC).
(3) BDF1 mice were immunized with a protein antigen, such as ovalbumin (OA) or keyhole limpet hemocyanin (KLH), absorbed to aluminum hydroxide gel, and their spleen cells were stimulated by homologous antigen for the formation of glycosylation-enhancing factor (GEF).
(4) "In an age where people can receive organ transplants, keyhole surgeries and targeted cancer treatments, it's really disappointing that the basic care needs of many young people with physical disabilities and other long-term health needs are not being met," added Field, a GP and ex-chair of the Royal College of GPs .
(5) When I had that keyhole surgery, I thought: ‘Maybe, if I come back, it won’t be to that top level.’ But with the support I have been getting from my coach, family and friends, I think that really motivated me to come back strong.” Kenya is more famed for its distance runners and steeplechasers than its hurdlers, but the country was left celebrating a surprise gold medal in the 400m hurdles when Nicholas Bett powered home from lane nine to smash his personal best to win in 47.79sec.
(6) The antibody responses of animals immunised with keyhole limpet hemocyanin (KLH) in Freund's Incomplete Adjuvant (FIA), diethylaminoethyl dextran (DEAE-dextran) and aluminium hydroxide (alum) were compared with the response to antigen administered in the absence of adjuvants.
(7) In addition to this HIV-specific B cell activation, the number of lymphocytes reactive with nonviral antigens such as DNA, myosin, actin, trinitrophenylated keyhole limpet hemocyanin, and ovalbumin was increased by a mean of 17.9-fold.
(8) Synthetic 131-149 and 140-149 sequences afforded 50 to 80% protection, both in the free state and conjugated with keyhole limpet hemocyanin.
(9) Feeding mice with OA or keyhole limpet haemocyanin in liposomes in a series of priming and boosting regimes failed to elicit any significant increase in serum or intestinal antibody response compared with feeding the free antigen.
(10) A tetrodotoxin-formaldehyde-keyhole limpet hemocyanin conjugate was used to immunize a rabbit for the production of anti-toxin antiserum.
(11) A panel of syngeneic monoclonal anti-idiotypic antibodies was prepared by immunizing A.SW mice with keyhole limpet hemocyanin-coupled A.SW monoclonal anti-myoglobin (HAL 19, IgG1) and screening the cloned hybridomas for production of IgG2 binding to idiotype but not to certain other anti-myoglobin antibodies of the same subclass in an ELISA.
(12) In admixture experiments, spleen cells from microfilaremic animals suppressed the proliferative responsiveness of cells from keyhole limpet hemocyanin (KLH)-immunized jirds to KLH by 38%, but had no effect on KLH-specific antibody production.
(13) B cells from these mice were transferred to irradiated recipients with T cells from keyhole limpet hemocyanin (KLH)-primed mice.
(14) In the absence of exogenous oleic acid (18:1), splenocytes responded to a T-dependent (TD) Ag (trinitrophenyl-keyhole limpet hemocyanin, TNP-KLH) at 37 degrees C but not at 27 degrees C. The addition of 150 microM 18:1 almost completely restored plaque-forming cell (PFC) responses to TNP-KLH at 27 degrees C but markedly suppressed PFC responses to the TD Ag at 37 degrees C. 3.
(15) Two forces are necessary and sufficient to produce the transformation of the newt neural plate from a hemispheric sheet of cells one cell thick to a keyhole shape.
(16) Fit metal, disc-shaped covers over keyholes and install a letterbox brush.
(17) Studying cellular immunocompetence we investigated the skin reactivity to various recall antigens (Candida, Trichophytin, Mumpsantigen, Streptokinase-Streptodornase, PPD), the primary immune response to Dinitrochlorobenzene (DNCB) and Keyhole Limpet Hemocyanin (KLH), and the lymphocyte transformation induced by mitogens (Phytohemagglutinin, Concanavaline A, Pokeweed Mitogen) and specific antigens.
(18) The peptide-keyhole limpet hemocyanin conjugates were used to immunize rabbits.
(19) have reported that the keyhole limpet hemocyanin (KLH)-specific suppressor factor is coded for by the I-J subregion of the H-2 complex (11).
(20) It was found that 2-3% of splenic T cells from arsonate-immune mice specifically bound the hapten using immunofluorescent keyhole limpet hemocyanin as a carrier.