(v. t.) To set on fire; to cause to burn with flame; to ignite; to cause to begin burning; to start; to light; as, to kindle a match, or shavings.
(v. t.) Fig.: To inflame, as the passions; to rouse; to provoke; to excite to action; to heat; to fire; to animate; to incite; as, to kindle anger or wrath; to kindle the flame of love, or love into a flame.
(v. i.) To take fire; to begin to burn with flame; to start as a flame.
(v. i.) Fig.: To begin to be excited; to grow warm or animated; to be roused or exasperated.
Example Sentences:
(1) The anticonvulsant properties of the endogenous excitatory amino acid antagonist, kynurenic acid (KYA), were studied in prepubescent and adult rats using the amygdaloid kindling model of epilepsy.
(2) For the purpose of contributing methodologically to experimental research on epilepsy, we investigated whether a difference exists in kindling development between acute and chronic preparations using identical species of animals, kindled brain tissues, stimulus intervals, and intensities.
(3) The kainate and quisqualate types of excitatory amino acid receptor were visualized autoradiographically in brain sections from rats kindled by stimulating the angular bundle.
(4) A corrective effect of Nicotinamide on oxidation processes in ganglion and neuroglial cells of cerebral cortex sensorimotor zone in "kindling" phenomenon was studied in the experiments on mice of C57BL line.
(5) PHT, CBZ, VPA, and CZP, SK&F 89976-A and SK&F 100330-A inhibited seizures in corneally kindled rats.
(6) The inhibitory effect of serotonin on the kindling model of epilepsy was investigated in the adult rat.
(7) In the second experiment, 15- and 30-day-old rats underwent unilateral carotid ligation followed by kindling in the ipsilateral amygdala.
(8) If Obama is your new iPad, Sarah Palin is your old Kindle.
(9) Electrical amygdaloid kindling was carried out with a 15 min inter-stimulus interval (ISI) in a control situation with intravenous (i.v.)
(10) We suggest that the NE-dependent mechanism responsible for the seizure suppression observed to follow concurrent, alternate stimulation and the suppression of seizure development using single-site kindling paradigms may be the same.
(11) GABAergic neurons and terminals are also increased in the hippocampus of seizure-sensitive gerbils, and kindling of the hippocampus and amygdala appears to enhance GABAergic inhibitory mechanisms.
(12) Based on an hypothesis that links electrical kindling in the limbic system (leading to seizures) to reverse tolerance or sensitivity to cocaine's effects, carbamazepine is being tested as a treatment for human cocaine users.
(13) reversed the increase in locomotion and elevation of multiple squeak thresholds in the bilaterally kindled rats.
(14) In fully kindled animals a stimulus-induced generalized seizure gave rise to a three-fold increase of noradrenaline levels in the stimulated hippocampus as compared to baseline levels (15-min samples).
(15) In the present work no significant differences were found between the behaviour of FG7142-kindled rats and vehicle-treated controls in social interaction test, elevated plus maze, or the Vogel conflict test of anxiety or in tests of home cage aggression or startle responses.
(16) Amygdaloid kindling of rats produced an increase in hippocampal Met5-enkephalin-Arg6-Gly7-Leu8 and cholecystokinin immunoreactivities and simultaneously a decrease in dynorphin A1-8 content.
(17) The data suggest that GABA-T inhibitors, such as vigabatrin, differ from most antiepileptic drugs previously tested in the kindling model in that they may produce both anticonvulsant and proconvulsant effects at the same dose in the same animal as a function of time after administration.
(18) However, the concentration of Asp decreased depending on the kindling stage, reaching the lowest value of 33% in comparison with the normal value.
(19) Thus, electrophysiological alterations within the first synaptic relay of the hippocampal trisynaptic circuit, the dentate gyrus, cannot explain the long duration of the kindling effect.
(20) In brightness discrimination reaction (BDR) the learning performance of PTZ-kindled animals was not influenced.
Kindler
Definition:
(n.) One who, or that which, kindles, stirs up, or sets on fire.
Example Sentences:
(1) Quantitative indirect immunofluorescence analysis by flow cytometry was used to determine the mean number of antibody binding sites per cell in a small subpopulation of rat brain cells expressing low levels of a cell surface differentiation antigen recognized by monoclonal antibody (Mab) RB13-6 (Kindler-Röhrborn et al.
(2) It is possible that Kindler syndrome and Weary's hereditary acrokeratotic poikiloderma are variants of the same disease.
(3) A review of 14 cases in the literature consistent with Kindler's syndrome showed this to be a definite clinical entity among the other bullous hereditary poikilodermas.
(4) We believe that this case best fits the designation of Kindler's syndrome.
(5) Jeffrey Kindler, Pfizer chief executive and chairman, abruptly stepped down Sunday after almost five years leading the world's biggest drugmaker, saying he needed to "recharge my batteries".
(6) An autosomal recessive mode of inheritance of Kindler syndrome is suggested in these two related families.
(7) Changes in homospecific activity (unit of enzyme activity per unit of enzyme protein; Rush, Kindler and Udenfriend, 1974.
(8) Kindler, who reorganised most of the company's operations, said he plans to spend more time with his family while preparing for new challenges, according to a company statement.
(9) Kindler's syndrome occurred in a 13-year-old boy with parental consanguinity.
(10) Constance Horner, the lead independent director of Pfizer's board, said in a statement that Kindler had recruited talented new leaders, set up more focused and agile business units and made the company stronger and more focused.
(11) Kindler, a Harvard Law School graduate and former McDonald's executive who joined Pfizer in 2002, revamped its sprawling pharmaceutical sales operation into five divisions that gave their leaders more control and responsibility.
(12) The corresponding tumors produce IL-3 and grow in vitro in the absence of exogenous IL-3 [Nair, A.P.K., Diamantis, I.D., Conscience, J.F., Kindler, V., Hofer, P. & Moroni, Ch.
(13) "Now that we are about to complete a full year of operating Pfizer and Wyeth together, with our world-class team fully in place, I have concluded the time is right to turn the leadership of the company over to Ian Read," Kindler said in a statement.
(14) the mutation that causes ribonuclease III (RNase III) deficiency in strain AB301-105 of Kindler et al.
(15) Read's predecessor Jeff Kindler, appointed in 2006 , had presided over years of underperformance at the pharmaceutical giant.
(16) Kindler also pulled off a huge acquisition that ensured Pfizer remains at the top of the pharmaceutical industry for years to come, buying Wyeth for $68bn (£43bn) in October 2009.
(17) A new synthesis starting from 4-phenoxy-methyl-benzonitrile, via a modified Willgerodt-Kindler reaction, is reported.
(18) These cells transiently express a cell surface determinant (CSD) specified by monoclonal antibody (Mab) RB13-2 (Kindler-Röhrborn, A. et al., Differentiation 30 (1985) 53-60), and recently identified as a set of O-acetylated gangliosides (Reinhardt-Maelicke, S. et al., submitted) also recognized by Mab D1.1 (Levine, J.M.
(19) One of Pfizer's first moves after Kindler's defenestration was a "Thank goodness it's Monday" programme to try to restore morale.
(20) A boardroom coup followed and Kindler was ousted with a $23m payoff.