(n.) Relationship by birth or marriage; consanguinity; affinity; kin.
(n.) Relatives by blood or marriage, more properly the former; relations; persons related to each other.
(a.) Related; congenial; of the like nature or properties; as, kindred souls; kindred skies; kindred propositions.
Example Sentences:
(1) No woman is at greater risk for ovarian carcinoma than one who is a member of a hereditary ovarian carcinoma syndrome kindred and whose mother, sister, or daughter has been affected with this disease and with an integrally related hereditary syndrome cancer.
(2) An unusual spectrum of craniofacial and foot abnormalities has been detected within a large midwestern Amish kindred.
(3) 45Calcium has been used to compare the kinetics for the transport and bioaccumulation of this regulatory cation in keratinocyte cultures of a kindred with HPS (i.e., one HPS homozygote, one HPS obligate heterozygote, one normal family member, and healthy adult controls).
(4) In this study, six patients, the proband, his four siblings and a niece, representing a kindred of fifty-two subjects, were examined for aymptomatic cutaneous nodules mainly on the back and chest.
(5) Recently, a gene for ITD (DYT1) in a non-Jewish kindred was located on chromosome 9q32-34, with tight linkage to the gene encoding gelsolin (GSN).
(6) A four-generation 25-member kindred with Factor XI:C deficiency is reported.
(7) In a nationwide investigation in South Africa, 25 affected individuals in 15 Afrikaner kindreds have been studied.
(8) found linkage between manic depression and HRAS1 in a single large Amish kindred.
(9) Longevity analysis demonstrated elongation of life expectancy for kindred members, and there was an apparent rarity of premature cardiac events.
(10) The logarithm of the odds ratio between GTHR and c-erbA beta was 3.67, and therefore GTHR mapped to the c-erbA beta locus in this kindred.
(11) To investigate the possibility that the syndrome is caused by mutation in a tumor suppressor gene, we searched for loss of heterozygosity in 16 sporadic basal cell carcinomas, 2 hereditary basal cell carcinomas, and 1 hereditary ovarian fibroma and performed genetic linkage studies in five Gorlin syndrome kindreds.
(12) In the present study, we have analyzed the IF staining patterns of skin and fibroblast cultures from Marfan syndrome patients and normal first-degree relatives in nine Marfan kindreds.
(13) Consanguinity of the kindreds could not be established.
(14) Here we demonstrate that in this kindred, which shows linkage to chromosome 21 markers, there is a point mutation in the APP gene.
(15) It also abolishes the Aval site (CTCGGG) in exon VI, which can be directly detected with the enzymatic DNA amplification technique (PCR) and offers the possibility of direct analysis in carrier and prenatal diagnosis in kindreds with this mutation.
(16) Kindred S showed the effect in man of heterozygous and homozygous expression of a dominant negative form of c-erbA beta.
(17) Lifetime risk of dementia in early-onset FAD kindreds is consistent with an autosomal dominant inheritance model.
(18) A kindred with an X-autosome translocation and differential inactivation of the X chromosome is described.
(19) Depending on the size of the kindred, the pedigree automatically obtains a rectangular or circular appearance.
(20) The W family represents the largest such North American kindred yet reported.
Sib
Definition:
(n.) A blood relation.
(a.) Related by blood; akin.
Example Sentences:
(1) The sexual attitudes and beliefs of 20 children who have been present at the labor and delivery of sibs and have observed the birth process are compared with 20 children who have not been present at delivery.
(2) We document four patients, including two sibs, with asphyxiating thoracic dystrophy and mild congenital hydrocephalus.
(3) However the study does not permit to reach any valid conclusions; further elaborate investigations alone could prove the useful role of genetic influence in the propagation of lepromin sensitivity to the subsequent sibs.
(4) The residual values were positively correlated in parent-offspring pairs and among sibs, both those presumed to be living together and those presumed to be living apart.
(5) A case of fragile-X syndrome (the Martin-Bell syndrome) in two male half-sibs from different marriages of their mother was described.
(6) No evidence was found of sex ratio anomalies in other classes of relative of pyloric stenosis index cases, whether or not the index cases had affected sibs.
(7) The ibd for grandparent-grandchild pairs is least affected by recombination, followed by sibs, half-sib, uncle-nephew, and first-cousin pairs.
(8) Nonagouti rats were significantly easier to approach, capture, and handle than their agouti sibs.
(9) This sib risk was apparent for probands with only a single hemivertebrum in addition to probands with more extensive vertebral defects and would support an etiological relationship between neural tube defects and other vertebral malformations.
(10) None of the sibs had BRA when the index case had BRA as part of a multiple malformation complex.
(11) probands and the estimated, future prevalence was found to be the same in sibs and children.
(12) The concept of LPC can also be used to interpret two factors which have been proposed to select for the Hamiltonian sex ratios: local mate competition is LPC acting through sons; and sib mating is LPC acting through daughters.
(13) We describe the concurrence of severe distal osteolysis, mental retardation, short stature, and characteristic facial appearance with maxillary hypoplasia and relative exophthalmos in two adult sibs, a 57-year-old woman and her deceased brother.
(14) To determine the relationship between so-called "diastrophic variant" and diastrophic dysplasia, four patients considered to have the variant condition were studied in detail and compared to 67 patients (including 17 sets of affected sibs) considered to have classical diastrophic dysplasia.
(15) The affected sib pair method revealed that in asthmatic families chi 2 = 4.9 (no significance) and in DF-specific IgE positive families chi 2 = 6.2 (p less than 0.05).
(16) CP proband frequencies of .004 for maternal half sibs and .009 for the paternal counterparts were also found.
(17) There is an early-onset form (with onset of symptoms under 2 years of age) where the illness is milder but more persistent, and where there is frequent occurrence of myasthenia in sibs.
(18) The increase is found with estimates of h2 based both on offspring mid-parent regression and on half sib analyses, but may be more marked with the former.
(19) Cumulative risk estimates were 26% for sibs born after the proband and 11% for sibs born before the proband (p less than 0.001).
(20) The one in three risk of spondylolysis to near relatives of patients with the dysplastic form of spondylolisthesis is emphasised in order that the deformity in their sibs and children can be recognised at any early age.