(1) Theophylline kinetics, as an in vivo probe for the potentially toxic cytochrome P-450I pathway of drug metabolism, were studied in 11 healthy volunteers and 11 patients with calcific chronic pancreatitis at Madras, South India.
(2) The testing of other models and their failure to describe the kinetic observations are discussed.
(3) To clarify the functional roles of His40, Glu58, and His92, we analyzed the consequences of several amino acid substitutions (His40Ala, His40Lys, His40Asp, Glu58Ala, Glu58Gln, and His92Gln) on the kinetics of GpC transesterification.
(4) Rise time and fall time constants have been quantified for describing kinetics of response.
(5) The enzyme, when assayed as either a phospholipase A2 or lysophospholipase, exhibited nonlinear kinetics beyond 1-2 min despite low substrate conversion.
(6) 1 The effects of chronic ethanol intake on the elimination kinetics of antipyrine were determined in nineteen male alcoholic subjects with comparison made to fourteen male volunteers.
(7) The addition of a cerebral blood volume (CBV) compartment in the [18F]2-fluoro-2-deoxy-D-glucose (FDG) model produces estimates of local CBV simultaneously with glucose metabolic rates when kinetic FDG studies are performed.
(8) Stability of kinetic constants for a long period of time is demonstrated.
(9) Kinetic analysis showed that the activators did not affect the Km for glycogen synthase D, for either enzyme.
(10) The kinetics of endocytosis and recycling of the wild-type and mutant receptors were compared.
(11) The kinetic parameters for the hydrolysis of type I, II and III collagens have been measured and are similar in magnitude to those for the tissue collagenases.
(12) Equilibrium and kinetic studies of the interaction of gene 32 protein of T4 phage with single-stranded fd DNA were performed monitoring the changes in protein fluorescence.
(13) The influence of vestibular dysfunction upon the vestibulospinal reflex (VSR) in two common peripheral syndromes was investigated by two types of posturographic examination: "static" posturography, recording and analyzing the postural sway in stance, and "kinetic" posturography, recording the stepping in place test.
(14) Analysis of enzyme kinetic properties revealed a Km of 0.7 mM for CO and of 65 microM for methyl viologen.
(15) The kinetic properties of the cell-free extracts fit mathematical models developed for in vitro systems reconstituted from purified enzymes.
(16) Kinetics of the insulin effect on MeAIB uptake were characterized by an increased Vmax.
(17) Typical kinetics of local anaesthetics are presented for various methods of regional anaesthesia informing the anaesthetist on corresponding plasma concentrations if the recommended maximum doses are exceeded and thus he gets useful information for his daily work.
(18) In this study, protein efficiency ratio and net protein utilization together with the kinetic estimates of protein turnover were used to compare the effect of different protein and fat sources in healthy rats.
(19) The kinetics of bimolecular decay of alpha-tocopheroxyl free radicals (T) was studied by ESR mainly in ethanol and heptanol solvents.
(20) The kinetics of the luminescent signal with the different luciferin esters varied significantly, indicating possible differences in the rates of uptake, breakdown and enzyme inhibition.
Thermodynamic
Definition:
(a.) Relating to thermodynamics; caused or operated by force due to the application of heat.
Example Sentences:
(1) From the previously observed results of preferential interactions for salting-out salts with proteins, it was shown that the free energy of the protein is increased by addition of the salts and this unfavorable free energy is smaller for the proteins bound to the columns because of their smaller surface area exposed to solvent; i.e., the bound form of the proteins is thermodynamically more stable.
(2) The viscosimetric and kinetic results are compared with the thermodynamic results obtained from the temperature dependence of the binding constants.
(3) The hypothesis that opiate agonism requires an N substituent in the axial position does not appear to be consistent with the increased potency of beta isomers in which axial N substituents are thermodynamically more unstable.
(4) Cleavage intensities were found to change with time in a manner that depended both on the site and on the drug, suggesting that topoisomerase II can move along the DNA from a kinetically preferred site to a thermodynamically preferred site.
(5) While the thermodynamics for (rGCGAGCG)2 and (rGCAGGCG)2 are similar, CD and the imino region of the proton NMR spectra indicate their structures are different.
(6) The complexes produced by both inhibitors are similar chemically since the thermodynamic parameters for activation to regenerate active enzyme are essentially identical.
(7) The thermodynamic activation energy of this reaction is 67.8 kcal mol-1.
(8) This is consistent with their thermodynamic and kinetic properties, since the H3O+ is often different from the Li+ in several orders of magnitude.
(9) Bounded, bulk, and perfusion-diffusion models are described in supersaturation, statistical, and thermodynamic frameworks.
(10) The effect of changes in the thermodynamic parameters on the equilibrium ensemble provides a further sensitivity check to the predictions.
(11) This is in keeping with thermodynamic principles which apply to chemical and biochemical reactions.
(12) The thermodynamics of this self-association have been evaluated by studying the temperature- and concentration-dependence of the mean residue ellipticity at 220 nm.
(13) This would allow the thermodynamic description of the role of proton translocation as that of a modificatory force of the structural parameters of proteins.
(14) The extrapolated aqueous solubility values in the absence of povidone were obtained as a function of temperature and were utilized to obtain thermodynamic parameters.
(15) Analysis of the thermodynamic parameters for the binding of 18 haptens forms the basis for proposing a model of the binding site of MOPC-104E.
(16) The relationships between thermodynamic quantities in a quaternary system of electrolytes are discussed in Appendix 2.
(17) The key assumptions are (1) that the target site is in the lower epidermis (basal layer) or in the dermis, and (2) that it is the thermodynamic activity (i.e., the free drug concentration, C*, of the active drug species) at the target site that is the true correlate of drug effectiveness.
(18) They also provide electronic and thermodynamic data that are not available from x-ray crystallographic data.
(19) Determination of the thermodynamic parameters from the calorimetric data has required the development of an analytical formalism that explicitly includes the thermodynamics as well as the kinetics of the transition.
(20) Thermodynamics of the enzyme-catalyzed (alkaline phosphatase, EC 3.1.3.1) hydrolysis of glucose 6-phosphate, mannose 6-phosphate, fructose 6-phosphate, ribose 5-phosphate, and ribulose 5-phosphate have been investigated using microcalorimetry and, for the hydrolysis of fructose 6-phosphate, chemical equilibrium measurements.