(1) Maybe it's left him knackered, but when we talk in the backroom of an ad hoc campaign office in the small agricultural town of Thrapston, he answers most questions using standard-issue candidate's boilerplate.
(2) The boys have just done eight gigs in nine nights and they're knackered.
(3) Prey is a gritty, concretey number, and while Reinhardt may be the least-kempt of the cast, every character drinks too much, looks constantly knackered and is therefore entirely believable.
(4) As Petra, another member of the team, finishes mopping the floors, and Andrew, the shift manager, cashes up the tills in the office downstairs, I slump on to a bar stool, knackered.
(5) The broadcaster described feeling like "a sort of knackered version of myself" after the stroke, which left him with mobility issues down his left side.
(6) "And watching the match, Pirlo and most of the Italians looked knackered, even misplacing easy short passes to unmarked colleagues, and either not making runs or making runs that were lazy and easy to catch off-side.
(7) Respected animal welfare organisations have warned governments for several years about the growing trade in knackered horses both between Ireland, the UK, France and Belgium, and between North and South America, and continental Europe.
(8) 71 min: Dean Windass, who looks knackered, is replaced by Caleb Folan.
(9) I lean on Suárez’s shoulder and tell him I’m knackered.
(10) But one staff member said: "It was like a car that looked good from the outside but it was knackered."
(11) ET 1 min: Both teams look knackered, with the exception of Gattuso on the Milan team, who looks like a Tazmanian devil on amphetamines.
(12) It's set in and around Kansas City 2044, but the future looks, frankly, knackered.
(13) 9.26pm GMT Arsenal substitution: Flamini on for Oxlade-Chamberlain, who looks knackered.
(14) It's feeling physically knackered, such as in the knees from years of standing up day after day.
(15) Real Madrid 3-1 Atlético Madrid (Marcelo ET 28) Atlético are knackered.
(16) "I arrived here just knackered, thinking I don't really want to do this," admits Coogan.
(17) He agreed, saying sitting back and absorbing constant attacks knackers you.
(18) Ministers were knackered and most had already disengaged from their jobs.
(19) Perhaps this is the person she truly wants to be – an ordinary mum, bit knackered, only able to get out of the house because her own mum's doing the babysitting – and was just unlucky to fall in love with Prince William rather than the local butcher.
(20) After all, being sleep deprived makes you miserable, knackered and liable to crash the car.
Ragged
Definition:
(imp. & p. p.) of Rag
(n.) Rent or worn into tatters, or till the texture is broken; as, a ragged coat; a ragged sail.
(n.) Broken with rough edges; having jags; uneven; rough; jagged; as, ragged rocks.
(n.) Hence, harsh and disagreeable to the ear; dissonant.
(n.) Wearing tattered clothes; as, a ragged fellow.
(n.) Rough; shaggy; rugged.
Example Sentences:
(1) Over the past 20 years the rag-and-bone trade has had a makeover.
(2) I usually use them as a rag with which to clean the toilet but I didn’t have anything else to wear today because I’m so fat.” While this exchange will sound baffling to outsiders, to Brits it actually sounds like this: “You like my dress?
(3) Confluent monolayers of capillary endothelial cells derived from Mongolian gerbil brain were irradiated with a single exposure of x-rays, and their radiosensitivity and sequential changes in morphology, staining intensity for factor VIII-related antigen (F VIII RAg), and capacity to produce prostacyclin (PGI2) were examined.
(4) Skeletal muscle mtDNA of three patients with mitochondrial encephalomyopathy, characterized clinically by myoclonic epilepsy and ragged-red fiber (MERRF) syndrome, has been sequenced to determine the underlying molecular defect(s).
(5) A distinctive pattern of subsarcolemmal mitochondrial aggregates, referred to as "ragged red fibers" in human mitochondrial myopathies, was observed in muscle biopsy samples from 1 dog.
(6) Endothelial cells of capillary vessels showed positive binding by UEA-1 lectin and the presence of factor VIII RAG.
(7) Four of the mutants had no effect on chylous ascites, but two mutants linked with ragged, and one unlinked, showed a complex situation involving enhancement, inhibition, epistacy and other interactions.
(8) There was a slight shortening in the thrombin time and a smaller increase in post-operative FVIII RAg and FVIII RCof levels in the HES group.
(9) There was no correlation between FVIII:RAg levels and radiation pneumonitis, radiation dose, volume of irradiated lung, tumor burden, or time-interval between exposure and sampling.
(10) In one of these, a probe designed specifically to detect deleted mtDNA identified abundant deleted mtDNA and its fusion transcript in RRF and lesser accumulations in non-ragged red cytochrome oxidase (COX) deficient fibres.
(11) Only in fragments of the biceps brachii muscle histological and histochemical investigations showed mitochondrial changes of the type of "ragged-red fibres".
(12) In situ hybridization to intact thymus and RNA blot analysis of isolated thymic subpopulations separated on the basis of T cell receptor (TCR) expression demonstrated that both TCR- and TCR+ cortical thymocytes express RAG-1 and RAG-2 messenger RNA's.
(13) Nuclear run-on assays showed that TPA completely repressed the transcription of RAG-1 within 30 min.
(14) A former Socialist party leader, he is a jovial, wise-cracking believer in consensus politics, who aides say never loses his rag and who so hates fights that he was once nicknamed "the marshmallow" within his own party, or "Flanby", after a wobbly caramel pudding.
(15) The Farage adviser said he looked back on many people within Ukip as “a bunch of rag-tag, unprofessional, embarrassing people who let Nigel down at every juncture.” He told the Guardian: “Someone needs to go in there with a big stick.
(16) Furthermore, we show that RAG can be expressed not only by CD3-TCR negative but also by CD3-TCRab or gd positive T-ALL cells.
(17) After fusion of HPRT- RAG cells with E. lutescens fibroblasts we demonstrated that the enzymes HPRT and G6PD are localized on the presumptive X chromosome.
(18) We analyzed the mitochondrial DNA of blood cells of 5 patients from a Chinese family with myoclonic epilepsy and ragged-red fiber disease.
(19) A small percentage of peripheral B cells also contained RAG-1 mRNA, raising the possibility that this protein may also be involved in immunoglobulin class switching.
(20) Exposure of isolated thymocytes to 12-O-tetra-decanoylphorbol 13-acetate (TPA)+ionomycin rapidly abolishes the expression of recombination-activating gene-1 (RAG-1) mRNA (3 h), down-regulates CD4 surface antigen expression (3 h), and enhances apoptosis (24 h).