(n.) The stoke of a bell tolled at a funeral or at the death of a person; a death signal; a passing bell; hence, figuratively, a warning of, or a sound indicating, the passing away of anything.
(n.) To sound as a knell; especially, to toll at a death or funeral; hence, to sound as a warning or evil omen.
(v. t.) To summon, as by a knell.
(1) The BBC Trust The green paper sounds the death knell for the BBC’s current governance system in the form of the BBC Trust, which it says has come under “sustained criticism” as a result of the Savile scandal, the £100m Digital Media Initiative fiasco and excessive payoffs and salaries to BBC executives.
(2) He said: "If Heathrow builds its runway, it will be the death knell of low-cost flying for a generation."
(3) In the Commons yesterday all the former ministers were rounded on by a succession of Labour MPs claiming the moment marked the death knell of New Labour.
(4) Fashion's current preoccupation with art is effectively the death knell of the minimalist look – most art (Donald Judd and his ilk aside) is about getting messy.
(5) The return of the jihadists is likely to sound the death knell for the anti-regime opposition in north Syria.
(6) Brexit may sound the death knell for this progress.
(7) Saleh's return to Yemen after more than three months would seem to sound the death knell for the exit plan and the start of a bid to consolidate his ruling party's power base, which crumbled in his absence.
(8) You are neither the death knell for immigration reform nor the prime mover of the GOP agenda.
(9) "As such, it is highly likely the chancellor's annuity announcement will also turn out to be disastrous for first-time buyers and could represent the death knell of aspirations of homeownership for millions of young families.
(10) It will be the death knell for the whole Scottish literature "project" – a crushing denial of an identity that writers have been meticulously accumulating, trying to maintain and refine.
(11) Last Post in Iraq: this is the death knell of the American empire | George Galloway Read more Gen Bednarek adds: “The tougher issue will be, ‘what’s next?’ We must have local Sunni police and our tribes of Falluja sustain the fragile security, re-establish governance, and provide for the people,” he says.
(12) The regime’s offensive has been seen in the opposition-held north as a death knell for the UN deal, negotiated by its special envoy Staffan de Mistura, for a six-week ceasefire in the city.
(13) His comments were seen by some as sounding the death knell of the plan.
(14) And while the poll tax may be beyond the memory of most active politicians (the infamous riot that sounded its death knell took place 24 years ago this week) its consequences live on, from a contributory role in Mrs Thatcher's downfall to a massive and damaging centralisation of funding for local councils.
(15) In what some have described the death-knell for “Abenomics” – his three-arrow policy of monetary easing, fiscal stimulus and structural reform – recent currency and market turmoil have wiped out the gains made soon after he became prime minister in late 2012.
(16) However, the switch to refrigerated lorries and growth in supermarket power sounded the death knell for many of these smaller farms, with the number of dairy farmers falling from 200,000 in the 1950s to around 10,000 today.
(17) The Department of Health last month publicly sounded the death knell for Labour's ill-fated £11.4bn national programme for IT, which began in 2002 and was said to be the largest civilian computer project ever undertaken.
(18) In what was being seen in Westminster last night as the death knell of New Labour and a return to a form of traditional left-right politics, Darling became the first chancellor since the 1970s to announce income tax increases, and also scrapped Gordon Brown's fiscal rules to sanction a doubling of borrowing this year.
(19) The changing nature of the labour market in the final quarter of the 20th century sounded the death knell for the old job for life and the smooth career progression, but, says Reeves, the self-employment model characterised by WVM provided a means of upward mobility.
(20) It will not just be the death knell for the farm but the death knell for the whole community,” said Alan Davies, managing director of the FUW.
(n.) A sign made for the purpose of giving notice to a person of some occurence, command, or danger; also, a sign, event, or watchword, which has been agreed upon as the occasion of concerted action.
(n.) A token; an indication; a foreshadowing; a sign.
(a.) Noticeable; distinguished from what is ordinary; eminent; remarkable; memorable; as, a signal exploit; a signal service; a signal act of benevolence.
(a.) Of or pertaining to signals, or the use of signals in conveying information; as, a signal flag or officer.
(v. t.) To communicate by signals; as, to signal orders.
(v. t.) To notify by a signals; to make a signal or signals to; as, to signal a fleet to anchor.
(1) Such a signal must be due to a small ferromagnetic crystal formed when the nerve is subjected to pressure, such as that due to mechanical injury.
(2) Glucocorticoids have numerous effects some of which are permissive; steroids are thus important not only for what they do, but also for what they permit or enable other hormones and signal molecules to do.
(3) Although solely nociresponsive neurons are clearly likely to fill a role in the processing and signalling of pain in the conscious central nervous system, the way in which such useful specificity could be conveyed by multireceptive neurons is difficult to appreciate.
(4) Theresa May signals support for UK-EU membership deal Read more Faull’s fix, largely accepted by Britain, also ties the hands of national governments.
(5) Type 1 changes (decreased signal intensity on T1-weighted spin-echo images and increased signal intensity on T2-weighted images) were identified in 20 patients (4%) and type 2 (increased signal intensity on T1-weighted images and isointense or slightly increased signal intensity on T2-weighted images) in 77 patients (16%).
(6) The presently available data allow us to draw the following conclusions: 1) G proteins play a mediatory role in the transmission of the signal(s) generated upon receptor occupancy that leads to the observed cytoskeletal changes.
(7) Thus, human bronchial epithelial cells can express the IL-8 gene, with expression in response to the inflammatory mediator TNF regulated mainly at the transcriptional level, and with elements within the 5'-flanking region of the gene that are directly or indirectly modulated by the TNF signal.
(8) The region containing the injection stop signal (iss) has been cloned and sequenced and found to contain numerous large repeats and inverted repeats which may be part of the iss.
(9) Here, we review the nature of the heart sound signal and the various signal-processing techniques that have been applied to PCG analysis.
(10) The present study was designed to test the hypothesis that the decreased Epi response following ET was due to 1) depletion of adrenal Epi content such that adrenomedullary stimulation would not release Epi, 2) decreased Epi release with direct stimulation, i.e., desensitization of release, or 3) decreased afferent signals generated by ET itself.
(11) In documents due to be published by the bank, it will signal a need to shed costs from a business that employs 10,000 people as it scrambles to return to profit.
(12) In fact, you might read it as a signal … that the president might well lose on this,” she said.
(13) Further study both of the signaling events that lead to MPF activation and of the substrates for phosphorylation by MPF should lead to a comprehensive understanding of the biochemistry of cell division.
(14) After several months, a temporal discrimination was well established, as shown by maximum suppression toward the end of the signal period.
(15) 2010 2 May : In a move that signals the start of the eurozone crisis, Greece is bailed out for the first time , after eurozone finance ministers agree to grant the country rescue loans worth €110bn (£84bn).
(16) Protein kinase C (PKC) is activated rapidly and transiently following ionizing radiation exposure and is postulated to activate downstream nuclear signal transducers.
(17) During that time they have repeatedly demonstrated the likely existence of signalling molecules or morphogens that control the pattern of development in the embryo.
(18) Recently, we have designed a series of simplified artificial signal sequences and have shown that a proline residue in the signal sequence plays an important role in the secretion of human lysozyme in yeast, presumably by altering the conformation of the signal sequence [Yamamoto, Y., Taniyama, Y., & Kikuchi, M. (1989) Biochemistry 28, 2728-2732].
(19) After calving, probably the position of new follicles is temporally influenced by direct signals from the uterine horns affected differently by pregnancy.
(20) The purpose of the present study was to investigate whether the signaling behaviors of female Long-Evans rats varies over the estrous cycle.