(n.) A hard protuberance; a hard swelling or rising; a bunch; a lump; as, a knob in the flesh, or on a bone.
(n.) A knoblike ornament or handle; as, the knob of a lock, door, or drawer.
(n.) A rounded hill or mountain; as, the Pilot Knob.
(n.) See Knop.
(v. i.) To grow into knobs or bunches; to become knobbed.
Example Sentences:
(1) The narrow intercellular ridge is smooth, whereas the epithelial cells have small cytoplasmic knobs between the cilia.
(2) The histochemical study of the LDH in the Trout embryo during the early organogenesis shows a specific localization in notochord cells, in mesodermic cells of the terminal knob and in some prosencephalic neuroblasts.
(3) Motor axons possessed elongate, irregularly shaped boutons en passant and morphologically variable boutons terminaux; the latter included huge endings with knobbed projectiles arising from thick collaterals, or smaller, round boutons from thin collaterals.
(4) Men might not have frills and furbelows as women traditionally do, but they’ve got spurious function: knobs on their watches or extra pockets on their jackets that are just as decorative as anything women wear.” 6.
(5) As with established cell lines, formation of zeiotic knobs at the isolated Type 1 cell surface appeared closely related to microfilamentous nets located beneath the plasmalemma.
(6) The isolated cells have an ovoid soma, a dendrite of variable length which terminates in a cilia-bearing knob and an axon, also of variable length.
(7) In addition, some reacted with either knob protrusions or caveolae of the host erythrocyte membrane; one reacted with a parasite-derived antigen present in the erythrocyte cytoplasm.
(8) "It might be that you think it's just a knob on the front panel, but maybe installing it requires you disassemble the front panel, and actually you need a mechanic to come and fit it," argues Rowley.
(9) wt from 80 to 95 kd in different knob-producing isolates of P. falciparum and is absent in knobless variants.
(10) To investigate environmental influences on the development of the olfactory epithelium, semi-thin sections were taken from the nasal septum of newborn and 30-day-old rabbits; the epithelial thickness and the number of olfactory knobs, supporting cells, dark basal cells, and receptor cells were compared.
(11) The spores of Rif-18 are pleomorphic and frequently exhibit terminal knobs.
(12) To investigate the involvement of actin filaments in concanavalin A (Con A)-induced cap formation and cytochalasin B (CB)-induced zeiotic knob migration, the distribution of F-actin was studied in Con A-treated and CB-treated Ehrlich ascites tumor cells (EATC) by fluorescence microscopy using heavy meromyosin conjugated with a fluorescent dye, N-(7-dimethylamino-4-methylcoumarinyl) maleimide, (DACM-HMM).
(13) 205 subjects each chose a "most pleasant" sound delivered through an earphone by turning the control knob on a continuously variable audio oscillator.
(14) Knobs which appear on the membrane of the infected erythrocytes adhere to the endothelium, causing the obstruction of cerebral microvessels.
(15) Cytoadherence of infected erythrocytes in vivo is associated with the presence of knobs on the erythrocyte surface, but we and others have shown recently that cytoadherence to C32 melanoma cells may occur in vitro in the absence of knobs.
(16) Systemic administration of the anti-inflammatory agent indomethacin blocked vascular leakage due to endothelial gap formation but had little or no effect on trophoblast knob penetration of vessels.
(17) After crossectomy which remains the most important stage, a short stripping is performed in an upward direction, substituting a packing for the olive shaped knob normally used.
(18) Under scanning electron microscopy, O. viverrini eggs looked like musk-melon skin; they had prominent shoulders and long knobs.
(19) Six culture-adapted knob-positive Plasmodium falciparum parasites, four of which were nonbinding in an in vitro cytoadherence assay, were tested for the presence of the knob-associated histidine-rich protein PfHRP1.
(20) Instead, there were free and spiral nerve terminals in the interstitium, and epilemmal knob-like or bouton-like endings surrounding non-encapsulated muscle fibers.
Knobby
Definition:
(a.) Full of, or covered with, knobs or hard protuberances.
(a.) Irregular; stubborn in particulars.
(a.) Abounding in rounded hills or mountains; hilly.
Example Sentences:
(1) Uninfected erythrocytes incubated in culture and erythrocytes infected with early or late forms of the knobless clones or the early forms of the knobby clone all failed to obstruct the microcirculation, although exhibiting various effects on bulk viscosity and peripheral resistance during flow.
(2) Other blebs were larger, more elongate, and less knobby, but had a similar ultrastructural organization.
(3) Indirect immunofluorescence, using affinity-purified monospecific antibodies directed against recombinant protein synthesized in Escherichia coli, localized the knob-associated histidine-rich protein to the membrane of knobby infected erythrocytes.
(4) Atypical, short, knobby mycelia with radiating projections were seen in nodular lesions in the lung.
(5) In the vas deferens, the knobby fibers, the diameters of which are multiples of that of the basic one, can be converted to single units by increasing the ionic strength.
(6) The nucleolar fibres in both the core and peripheral regions were irregular and knobby, with a diameter of about 15 nm.
(7) Binding of both knobby and knobless infected erythrocytes to autologous leukocytes including monocytes, neutrophils, lymphocytes and plasma cells was found in some of the primary in vitro cultures.
(8) The only gross morphologic change in stifle joints with a severed ligament was enlarged knobby remnants of the CaCL.
(9) Differential screening of cDNA libraries constructed from knobby and predominantly knobless Plasmodium falciparum isolates, identified the sequence SD17.
(10) These proteins appeared to be aggregated or condensed in the area of the knob, whereas the remainder of the red cell surface showed no such dense clusters; haemoglobin and the histidine-rich protein of P. lophurae could not be localized to the knobby protuberances.
(11) Erythrocytes infected with a knobby variant of Plasmodium falciparum selectively bind IgG autoantibodies in normal human serum.
(12) The change from a nucleosomal organization to bundles of smooth filaments appeared to result from a complex process involving the transitory presence of conspicuous "knobby fibers" that suggest a periodicity in the organization of the spermatidal proteins along the DNA molecules.
(13) The observed alterations in P falciparum-infected red cell membrane phospholipid distribution, which is independent of the presence or absence of knobby protuberances, might be associated with the drastic changes in cell membrane permeability and susceptibility to early hemolysis observed in the late stages of parasite development.
(14) Naturally occurring anti-band 3 autoantibodies bind to erythrocytes infected with a knobby variant of the human malaria Plasmodium falciparum (FCR-3 strain).
(15) The dendrites have knobby, nodular protuberances which give them a gnarled appearance.
(16) This unusual ornamentation consists of blunt projections rising out of an otherwise smooth surface and is termed "knobby."
(17) The projection of knobby protuberances at the cell surface (zeiosis) is a general cellular response to cytochalasin D (CD), resulting from herniation of endoplasm through undefended places of the cortex during cell contractions and displacement of microfilaments induced by CD.
(18) The lowest band (band I) was found to consist of thick rod-shaped particles (330 by 80 nm) with knobby surfaces and with occasional protrusion at one end.
(19) The genomic organization of the knob protein (KP) gene of knobby (K+) and knobless (K-) variants of the Thai isolate NT 108 and the Gambian isolate FCR-3 are compared.
(20) In this study, we used the technique of whole cell mount electron microscopy to determine if the ultrastructure of the erythrocyte cytoskeleton changed following parasitization with knobby and knobless strains of P. falciparum.