(n.) A figure the lines of which are interlaced or intricately interwoven, as in embroidery, gardening, etc.
(n.) A fastening together of the pars or ends of one or more threads, cords, ropes, etc., by any one of various ways of tying or entangling.
(n.) A lump or loop formed in a thread, cord, rope. etc., as at the end, by tying or interweaving it upon itself.
(n.) An ornamental tie, as of a ribbon.
(n.) A bond of union; a connection; a tie.
(n.) Something not easily solved; an intricacy; a difficulty; a perplexity; a problem.
(n.) A cluster of persons or things; a collection; a group; a hand; a clique; as, a knot of politicians.
(n.) A portion of a branch of a tree that forms a mass of woody fiber running at an angle with the grain of the main stock and making a hard place in the timber. A loose knot is generally the remains of a dead branch of a tree covered by later woody growth.
(n.) A knob, lump, swelling, or protuberance.
(n.) A protuberant joint in a plant.
(n.) The point on which the action of a story depends; the gist of a matter.
(n.) See Node.
(n.) A division of the log line, serving to measure the rate of the vessel's motion. Each knot on the line bears the same proportion to a mile that thirty seconds do to an hour. The number of knots which run off from the reel in half a minute, therefore, shows the number of miles the vessel sails in an hour.
(n.) A nautical mile, or 6080.27 feet; as, when a ship goes eight miles an hour, her speed is said to be eight knots.
(n.) A kind of epaulet. See Shoulder knot.
(n.) A sandpiper (Tringa canutus), found in the northern parts of all the continents, in summer. It is grayish or ashy above, with the rump and upper tail coverts white, barred with dusky. The lower parts are pale brown, with the flanks and under tail coverts white. When fat it is prized by epicures. Called also dunne.
(v. t.) To tie in or with, or form into, a knot or knots; to form a knot on, as a rope; to entangle.
(v. t.) To unite closely; to knit together.
(v. t.) To entangle or perplex; to puzzle.
(v. i.) To form knots or joints, as in a cord, a plant, etc.; to become entangled.
(v. i.) To knit knots for fringe or trimming.
(v. i.) To copulate; -- said of toads.
Example Sentences:
(1) Two years ago I met a wonderful man and we now feel it’s time to tie the knot.
(2) The tinsel coiled around a jug of squash and bauble in the strip lighting made a golf-ball size knot of guilt burn in my throat.
(3) It is emphasized that surgeons should be more aware of the relationship of the holding power of surgical knots to not only the knot-typing technique but also the kind of suture material used.
(4) When a supercoiled substrate bearing two FLP target sequences in inverse orientation is treated with FLP, the products are multiply knotted structures that arise as a result of random entrapment of interdomainal supercoils.
(5) In principle, the more turns and throws the stronger the knot.
(6) Also numerous small knots on the small intestine, peritoneum, and omentum, as well as a considerable amount of ascites were observed.
(7) Suture knots are buried in the sclera to minimize the risk of late-onset endophthalmitis.
(8) The catheter with intact triple knots could be withdrawn without an invasive maneuver.
(9) A more detailed analysis of the products from recombination between wild-type sites indicates: (1) that the catenanes or knots produced by recombination are both simple and complex; (2) that the ratio of free products to catenanes is independent of the distance between the two directly repeated loxP sites; and (3) that for DNA substrates with four loxP sites significant recombination between non-adjacent sites occurs to give free circular products.
(10) This article studies the different knots, modalities and sutures.
(11) The mechanical performance of these sutures was judged by the following parameters: knot breakage force, configuration of secure knots, and knot run down force.
(12) This could be of important use in expediting root-knot nematode resistance (based on the Aps 1-linked resistance gene Mi) screening for breeding programs, or F1 testing for seed production purposes.
(13) After this manoeuvre, both the introducer and the small knot could be withdrawn from the jugular vein without further incident.
(14) The former appears characteristic of circularly bent DNA and gives rise to a substantial retardation, the latter of bending across a knot or kink in the DNA chain associated with a relatively minor retardation relative to standards.
(15) The suture appears to be solid, and the knots do not loosen.
(16) Now before you get your knickers in a knot, of course I love my children – and I do a decent job of caring for them.
(17) With respect to handling, knotting, tissue drag, absorption, and postoperative complications, the improved Dexon suture was found to be well suited for use in cataract surgery.
(18) The reduced phacoemulsification incision size in combination with a scleral pocket closed with a continuous single knotted 10-0 monofilament nylon suture under tonometric and keratometric control significantly dampens the changes in corneal astigmatism during the early and late postoperative periods.
(19) Two new triterpenoid saponins, wistariasaponins D [1] amd G [2], and the known saponin dehydrosoyasaponin I [3] were isolated from the knots of Wistaria brachybotrys.
(20) Loose ends in efforts to untangle the Gordian knot of Syria | Letters Read more “What is important is Russia has to not be engaged in any activities against anybody but [Isis],” secretary of state John Kerry said.
Unbind
Definition:
(v. t.) To remove a band from; to set free from shackles or fastenings; to unite; to unfasten; to loose; as, unbind your fillets; to unbind a prisoner's arms; to unbind a load.
Example Sentences:
(1) Thus, although the fast sodium inactivation process is not required for tonic and use-dependent block of INa by disopyramide, it contributes to the fast phase of block development and unbinding from use-dependent block.
(2) Two calcium antagonistic drugs, nifedipine and mesudipine, were investigated and as a result averaged rate constants of binding and unbinding were evaluated.
(3) Physical theories have been developed to describe many aspects of their conformational behaviour, such as the preferred shapes and shape transformations of closed vesicles, and the shape fluctuations, random-surface configurations, and adhesion and unbinding of interacting membranes.
(4) Assuming a reversible one-to-one binding reaction, the time course of DHO binding and unbinding was analysed under a variety of conditions.
(5) Sanguinarine may produce a K+-like effect upon the Na pump with consequent unbinding of ouabain.
(6) The rate constants for binding and unbinding of ATP were estimated from the dependence of the mean open time on [ATP] and from the Ki.
(7) The rate for unbinding during depolarization was independent of pHo.
(8) We suggest that these conformational changes arise from the unbinding to DNA of certain basic tails of histone(s), and that a competition for DNA binding locations exists upon the reassociation.
(9) These findings suggest than AN-132 has use dependent inhibitory action on the fast sodium channel by binding to the channel mainly during its activated state and that the unbinding rate of the drug during diastole is very slow.
(10) Because in most cases these fit a single exponential with a mean open duration like that of modified channels, we conclude that voltage-dependent toxin unbinding produced a mixed population of unmodified and modified openings.
(11) The extent of the contribution of the process of agonist binding and unbinding to adenylate cyclase activation has not been demonstrated or quantified.
(12) It is interesting that encainide and flecainide unbind slowly (15-20 seconds), whereas lidocaine and moricizine unbind rapidly (0.2-1.3 seconds).
(13) Therefore, sodium channel states regulate the binding and unbinding behaviour of antiarrhythmic drugs.
(14) Such [Ca2+]i-transients in muscle are actually subcellular spatio-temporal events that are determined dynamically by i) diffusional fluxes of Ca2+, ii) by the binding or unbinding of Ca2+ to ligands such as troponin c and calmodulin, and iii) by the various cellular processes, such as release of Ca2+ from sarcoplasmic reticulum, that produce fluxes of Ca2+ across the membranes bounding organelles or the cell.
(15) According to the model, RAC109-I and RAC109-II have significantly different unbinding rate constants for channels when they exist predominantly in rested, activated, or inactivated states, as well as significantly different binding rate constants when channels are activated.
(16) We conclude that binding and unbinding of one molecule of ATP determine the gating of ATP-sensitive K+ channel.
(17) The dissociation rate constant of DHO unbinding remained unchanged (approximately 0.06 s-1).
(18) Estimates of binding and unbinding rate constants for the sodium channel during the action potential plateau and after repolarization were of the same order as previous results obtained using microelectrode methods in vitro.
(19) Increasing the concentration of drug increased the rate of binding but had little or no effect on unbinding, as expected for a simple bimolecular reaction.
(20) Binding and unbinding of MK-801 seems to be possible only if the N-Me-D-Asp-operated channel is in the transmitter-activated state: MK-801 was effective only when applied simultaneously with N-Me-D-Asp, and recovery from MK-801 blockade was speeded by continuous exposure to N-Me-D-Asp [time constant (tau) approximately equal to 90 min at -70 to -80 mV].