(n.) A figure the lines of which are interlaced or intricately interwoven, as in embroidery, gardening, etc.
(n.) A fastening together of the pars or ends of one or more threads, cords, ropes, etc., by any one of various ways of tying or entangling.
(n.) A lump or loop formed in a thread, cord, rope. etc., as at the end, by tying or interweaving it upon itself.
(n.) An ornamental tie, as of a ribbon.
(n.) A bond of union; a connection; a tie.
(n.) Something not easily solved; an intricacy; a difficulty; a perplexity; a problem.
(n.) A cluster of persons or things; a collection; a group; a hand; a clique; as, a knot of politicians.
(n.) A portion of a branch of a tree that forms a mass of woody fiber running at an angle with the grain of the main stock and making a hard place in the timber. A loose knot is generally the remains of a dead branch of a tree covered by later woody growth.
(n.) A knob, lump, swelling, or protuberance.
(n.) A protuberant joint in a plant.
(n.) The point on which the action of a story depends; the gist of a matter.
(n.) See Node.
(n.) A division of the log line, serving to measure the rate of the vessel's motion. Each knot on the line bears the same proportion to a mile that thirty seconds do to an hour. The number of knots which run off from the reel in half a minute, therefore, shows the number of miles the vessel sails in an hour.
(n.) A nautical mile, or 6080.27 feet; as, when a ship goes eight miles an hour, her speed is said to be eight knots.
(n.) A kind of epaulet. See Shoulder knot.
(n.) A sandpiper (Tringa canutus), found in the northern parts of all the continents, in summer. It is grayish or ashy above, with the rump and upper tail coverts white, barred with dusky. The lower parts are pale brown, with the flanks and under tail coverts white. When fat it is prized by epicures. Called also dunne.
(v. t.) To tie in or with, or form into, a knot or knots; to form a knot on, as a rope; to entangle.
(v. t.) To unite closely; to knit together.
(v. t.) To entangle or perplex; to puzzle.
(v. i.) To form knots or joints, as in a cord, a plant, etc.; to become entangled.
(v. i.) To knit knots for fringe or trimming.
(v. i.) To copulate; -- said of toads.
Example Sentences:
(1) Two years ago I met a wonderful man and we now feel it’s time to tie the knot.
(2) The tinsel coiled around a jug of squash and bauble in the strip lighting made a golf-ball size knot of guilt burn in my throat.
(3) It is emphasized that surgeons should be more aware of the relationship of the holding power of surgical knots to not only the knot-typing technique but also the kind of suture material used.
(4) When a supercoiled substrate bearing two FLP target sequences in inverse orientation is treated with FLP, the products are multiply knotted structures that arise as a result of random entrapment of interdomainal supercoils.
(5) In principle, the more turns and throws the stronger the knot.
(6) Also numerous small knots on the small intestine, peritoneum, and omentum, as well as a considerable amount of ascites were observed.
(7) Suture knots are buried in the sclera to minimize the risk of late-onset endophthalmitis.
(8) The catheter with intact triple knots could be withdrawn without an invasive maneuver.
(9) A more detailed analysis of the products from recombination between wild-type sites indicates: (1) that the catenanes or knots produced by recombination are both simple and complex; (2) that the ratio of free products to catenanes is independent of the distance between the two directly repeated loxP sites; and (3) that for DNA substrates with four loxP sites significant recombination between non-adjacent sites occurs to give free circular products.
(10) This article studies the different knots, modalities and sutures.
(11) The mechanical performance of these sutures was judged by the following parameters: knot breakage force, configuration of secure knots, and knot run down force.
(12) This could be of important use in expediting root-knot nematode resistance (based on the Aps 1-linked resistance gene Mi) screening for breeding programs, or F1 testing for seed production purposes.
(13) After this manoeuvre, both the introducer and the small knot could be withdrawn from the jugular vein without further incident.
(14) The former appears characteristic of circularly bent DNA and gives rise to a substantial retardation, the latter of bending across a knot or kink in the DNA chain associated with a relatively minor retardation relative to standards.
(15) The suture appears to be solid, and the knots do not loosen.
(16) Now before you get your knickers in a knot, of course I love my children – and I do a decent job of caring for them.
(17) With respect to handling, knotting, tissue drag, absorption, and postoperative complications, the improved Dexon suture was found to be well suited for use in cataract surgery.
(18) The reduced phacoemulsification incision size in combination with a scleral pocket closed with a continuous single knotted 10-0 monofilament nylon suture under tonometric and keratometric control significantly dampens the changes in corneal astigmatism during the early and late postoperative periods.
(19) Two new triterpenoid saponins, wistariasaponins D [1] amd G [2], and the known saponin dehydrosoyasaponin I [3] were isolated from the knots of Wistaria brachybotrys.
(20) Loose ends in efforts to untangle the Gordian knot of Syria | Letters Read more “What is important is Russia has to not be engaged in any activities against anybody but [Isis],” secretary of state John Kerry said.
Unknot
Definition:
(v. t.) To free from knots; to untie.
Example Sentences:
(1) Initially, all attempts to unknot or remove the catheter failed.
(2) "Well…" His delightful press secretary, Lena, starts giggling as her boss tries to unknot himself from this contradiction.
(3) The purpose of this study was to identify possible mechanisms of resistance present in these cells by using human mdr1 and topoisomerase II DNA probes, antibodies to these gene products, and P4 phage unknotting assay for topoisomerase II activities.
(4) The extractable topoisomerase II activity of Bloom's syndrome fibroblasts, as measured by unknotting of page P4 DNA, is much more strongly inhibited by cell growth in medium containing BrdU than is that of normal fibroblasts.
(5) In the present study, we found that nuclear extracts of these sublines (approximately 50- and approximately 140-fold resistant to VM-26) required 2 and 8 times more adenosine 5'-triphosphate (ATP), respectively, to achieve half-maximal stimulation of unknotting activity compared to extracts from the sensitive cells.
(6) In the presence of 500 microM ATP, equimolar concentrations of 2-bromo-dATP, dideoxy-ATP, 2-chloro-dATP, 2-fluoro-dATP, and dideoxy-GTP nucleotide analogues inhibited the unknotting activity of the Topo II enzyme.
(7) Sensitivity of the topo II unknotting assay to inhibition by VP-16 was the same for the parent and all resistant cell lines.
(8) The phage P4-unknotting activity of nuclear extracts decreased 2-fold when AA8 cells entered into the non-cycling state, but there was no difference in sensitivity to amsacrine between log- and plateau-phase nuclear extracts.
(9) Methods are described for accurate measurement of 10-100 ng of unknotted P4 DNA.
(10) Our preliminary results demonstrate remarkable activity of Topo II with specific conversion of knotted form P4 DNA to unknotted form in human kidney cancer cells, YCR and ACHN.
(11) The conditions for the reactions of relaxation, unknotting, decatenation, and catenation were found to be similar to those observed with enzymes from other eukaryotic cells.
(12) The ATP concentration required for equivalent activity in a DNA-unknotting assay is 2- to 8-fold higher in nuclear extracts from drug-resistant cell lines as compared with the parental line.
(13) Several quinolones and antitumor compounds were tested as inhibitors of purified calf thymus topoisomerase II in unknotting, catenation, radiolabeled DNA cleavage, and quantitative nonradiolabeled cleavage assays.
(14) This method check relative Topo II activity with its conversion of knotted form P4 phage DNA to unknotted form.
(15) Regular chromic material was stronger in unknotted tensile strength and fracture load for all gauges.
(16) P4 unknotting assays of the purified nuclear type II topoisomerase in the presence of m-AMSA and VM-26 indicated that the mitochondrial and nuclear enzymes behaved similarly, although the mitochondrial enzyme appeared to be inhibited more strongly.
(17) More than 99% of the inversion products were unknotted rings.
(18) The enzyme can catenate supercoiled DNA molecules, unknot DNA, and cleave double-stranded DNA.
(19) Topoisomerase II activity in nuclear extracts, as determined by the P4 phage DNA-unknotting assay, was more easily detected and measured at lower NaCl concentrations in NCI-H69 than in NCI-H187 cells.
(20) The level of DNA topoisomerase II protein, detected by antibody staining, decreased concomitantly with a general decrease in DNA topoisomerase II unknotting activity, while DNA topoisomerase I activity was not affected.