(1) The transition was characterized by a single first order rate constant (kobs,i) which was independent of enzyme concentration.
(2) Knowledge of the salt dependences of ka and of the observed equilibrium constance Kobs of the ligand-nucleic acid interaction should usually be sufficient to determine whether a screening controlled mechanism or a pre-equilibrium mechanism is suitable to describe the process.
(3) A log kobs versus pH profile for the approach to the ionization equilibrium was determined, and a mechanism consistent with the profile was postulated.
(4) In the absence of cyanide, ferrocytochrome a3 appears at a rate (kobs) of 0.016 s-1.
(5) Above 25 microM AT.H complex, an increasing dead time displacement of p-aminobenzamidine and a downward deviation of kobs from the initial linear dependence on AT.H complex concentration were found, reflecting the saturation of an intermediate Xa.AT.H complex with a KD of 200 microM and a limiting rate of Xa-AT product complex formation of 140 s-1.
(6) At pH 7.8, the apparent single rate constant for association (kobs) at 4 degrees C was 4.72 x 10(+5).M-1.min-1.
(7) Thus, under pseudo-first order conditions ([AT]o, [H]o much greater than [T]o much less than [P]o), the observed thrombin inactivation rate constant (kobs) exhibited a saturable dependence on [AT]o or [H]o when [H]o much less than KT,H, reflecting a KAT,H (0.25 microM) similar to that directly determined by equilibrium binding.
(8) The nature of the anion often has a major effect on the magnitude of the equilibrium constant (Kobs) and rate constant (kobs) of protein-DNA interactions, but a minor effect on SKobs and Skobs, which are dominated by the cation stoichiometry.
(9) The rate constant (kobs) for loss of ADP activation exhibits a nonlinear dependence on 2-BDB-TAMP concentration, suggesting a reversible binding of reagent (KR = 0.74 mM) prior to irreversible modification.
(10) The kobs max value in tissues from insulin-dependent diabetic patients was significantly greater than that in tissues from either noninsulin-dependent diabetics or nondiabetics.
(11) Reduction by lumiflavin semiquinone followed single exponential kinetics and the observed rate constant (kobs) was linearly dependent on protein concentration (k = 1.8 X 10(7) M-1s-1 heme-1).
(12) At 0.25 M-KX, the increase in Kobs for Osym is observed to be approximately 40-fold, whereas for non-operator DNA the increase in Kobs is estimated by extrapolation to be approximately 300-fold.
(13) The Kobs of this reaction reflects the difference between the observed standard free energy change (delta G-oobs) for the hydrolysis of acetylcholine and the delta G-oobs for the hydrolysis of acetyl-CoA.
(14) The observed equilibrium constants (Kobs) of the creatine kinase (EC 2.7.3.2), myokinase (EC 2.7.4.3), glucose-6-phosphatase (EC 3.1.3.9), and fructose-1,6-diphosphatase (EC 3.1.3.11) reactions have been determined at 38 degrees C, pH 7.0, ionic strength 0.25, and varying free magnesium concentrations.
(15) Stopped-flow spectrophotometry also showed that electron transfer from the Fe-protein to the MoFe-protein in states E0 and E1H occurs at the same rate (kobs.
(16) A study of kobs vs pH suggests this active-site lysine has a pKa of 8.1 and a pH-independent rate constant of inactivation of 47,700 M-1 min-1.
(17) At all temperatures, the pH strongly influenced the observed degradation rate constant (kobs) values, with rate minima observed near pH 4.
(18) Alkylation of the N-terminal half resulted in biphasic calcium release with rates (kobs 153 s-1 and 10.9 s-1 respectively) similar to those observed in intact alkylated calmodulin.
(19) At 1.2 mM 2-BDB-TAMP, kobs = 0.060 min-1 and is not affected by alpha-ketoglutarate or GTP, but is decreased to 0.020 min-1 by 5 mM NADH and to zero by 5 mM ADP.
(20) A plot of the pseudo-first order rate constant (Kobs) versus T1K concentration was linear, and values for the association (k1) and dissociation (k-1) rate constants were obtained.
Lob
Definition:
(n.) A dull, heavy person.
(n.) Something thick and heavy.
(v. t.) To let fall heavily or lazily.
(v. t.) See Cob, v. t.
(n.) The European pollock.
Example Sentences:
(1) But Real are not giving them a chink to exploit so, eventually, Neymar lobs a ball into the box.
(2) There was still time for Saborio to try an audacious lob from distance to steal the game, but Nielsen, who'd looked ponderous in his movements all game, was able to watch this one safely over.
(3) He dictates the next rally and when Murray decides to go for another lob, Dimitrov is on to the ruse and swats a contemptuous smash away to seal the first set that flashed by in the blink of an eye!
(4) But Murray drags it back to deuce, a lob from him and a missed slice from Federer making it so.
(5) Before placing further questions on the notice paper, he lobs this at Bill Shorten.
(6) Italy crashed out, though Fabio Quagliarella’s valedictory lob from distance deep into injury time ensured they at least departed South Africa with a flourish.
(7) "I think his genius is to make people feel comfortable, and then lob in the incendiary."
(8) Before he left, Peter had one more grenade to lob at both of us.
(9) Stoke's Glenn Whelan was sent off for a very silly second yellow card, Hughes found himself banished from the bench for protesting – lobbing his managerial anorak over the dugout roof in disgust en route – and Marc Wilson was also dismissed after conceding a penalty.
(10) First, Álvaro Negredo, once of this parish, came close to lobbing Bravo as the goalkeeper back-pedalled to tip over.
(11) No wonder that Ed Miliband has found it so easy to lob verbal grenades.
(12) He’s not in power yet, so he still gets to blunder around lobbing out daft policies willy-nilly in the hope that one of them will scan.
(13) The assistants – old garage heads who clearly loathed this racket the kids were making – dismissively lobbed a pile of white labels on to the counter.
(14) "So is that hairdo," he lobs back, "but I figure that's your business."
(15) So the idea of a benevolent dictator is not my cup of tea Rand Paul Paul said polls became part of “a self-reinforcing news cycle because of the celebrity nature that goes on, on and on”, though he accepted that voters might “at a superficial level be attracted to bombast, insults, junior high sort of lobbing of verbal bombs that kind of stuff”.
(16) An officer suggested tear gas would quieten them down and a gas canister was lobbed into the transport.
(17) Those guys played some unbelievable lobs and angles.
(18) In another largely Muslim neighbourhood, PK12, families camp out in grass and mud with buckets, carpets, mattresses, discarded rubbish, cooking pots over charcoal fires and a constant fear of lobbed grenades.
(19) She agreed to this interview to discuss Labour's plans to draft landmark legislation on women's safety , but that was before the inquiry into child abuse was announced, and before deputy Labour leader Harriet Harman lobbed a bomb into the party hierarchy, insisting that the Gordon Brown era was marked by sexism and inequality.
(20) Leicester had nothing in response and United had the chances to put a more emphatic slant on the scoreline, with Rashford testing Schmeichel and Mata blowing a one-on-one with a fluffed attempted lob.