(1) Plots of the observed rate constant for [3H]-QMDP-receptor complex formation, kon, versus [3H-QMDP] were linear at both 30 degrees C and 10 degrees C, consistent with the interaction of [3H]-QMDP with the H1-receptor being a simple, one-step equilibrium.
(2) The time course of the binding of a radioligand in the presence of a competing unlabeled ligand was analyzed in terms of rate constants of association (kon) and dissociation (koff) for binding of the radioligand and the competitor.
(3) The tension of the tonic response to Carb was unaffected by cooling and was only inhibited by nifedipine at 0.3 microM Carb at 37 degrees C. Both cooling and nifedipine, at 37 degrees C, decreased the rate constant of onset of the tonic response (kon) to Carb.
(4) Baboon elastase, however, is as effectively blocked with Eglin c (kon = 2.5 x 10(7) M-1s-1) as human elastase.
(5) Analysis of the kinetics of [125I- Tyr11]SRIF binding showed that the rate constant for association (kon = 1.7 x 10(8) M-8min-1) was similar to that for [125I-Tyr1]SRIF (0.8 x 10(8) M-1min-1).
(6) The rate constant for binding (kon) was 8 x 10(7) M(-1) min(-1).
(7) This slow kon suggests either hindered access to the inhibitory allosteric site or that a fast binding step is followed by a slower conformational change leading to channel inhibition.
(8) The second compound has the same structure as a ganglioside recently found by us (Taki, T., Rokukawa, C., Kasama, T., Kon, K., Ando, S., Abe, T., and Handa, S., J. Biol.
(9) MEP maps of the protonated analogs are correlated to differences in the value of kon, the microscopic association constant.
(10) Kinetic analysis revealed a rapid onset of steady-state inhibition (kon = 1.35 X 10(4) M-1 s-1) followed by slow dissociation of inhibitory complex(es) with a half-life of 8.2 h. The inhibitory complex was shown to consist of E...I...ATP in equilibrium with E...I, Pi, and ADP.
(11) Thor Heyerdahl’s Kon-Tiki expedition was a product of the European enlightenment’s belief in progressive learning.
(12) We need people to have confidence in us.” In a statement to Guardian Australia, Lawrie said: “It’s always open for anyone to put their hand up for leadership, and unlike the CLP our great Labor party has a democratic process.” Kon Vatskalis, a former long-serving Labor member, said on Tuesday he had written to Lawrie asking her to resign “for the good of the party”.
(13) Secretory leukocyte proteinase inhibitor (SLPI) blocks the elastase of all three species with high efficiency; baboon elastase shows the highest association rate constant (kon = 5.6 x 10(7) M-1s-1) followed by human elastase (kon = 4.1 x 10(7) M-1s-1) and finally sheep elastase (kon = 1.2 x 10(7) M-1s-1).
(14) These results enable calculation of real time rate values for the enzyme-primer association (kon = 5.7 x 10(8) M-1 s-1) and dissociation (koff = 1.6 s-1).
(15) Kinetic analysis revealed a kon of 3 x 10(5) M x s-1 at 30 degrees C and pH 5.5.
(16) The reaction of the serine proteinases with the PMN-I was characterized by the determination of the association rate constant kon.
(17) The mutation affects the charge stabilizing system and the primary binding pocket of thrombin as depicted by a decrease in Kon for diisopropylfluorophosphate (9.5-fold) and for N alpha-p-tosyl-L-lysine-chloromethyl ketone (51-fold) and a 39-fold increase in the Ki for benzamidine.
(18) 3H-(-)-bupranolol associated to beta-adrenoceptors of lung membranes with a kon 1.21 X nmol-1 X min-1 and dissociated with a koff of 0.26 min-1.
(19) We now report that the binding rate (kon) of the mAb is 3-fold higher in the presence of Ca2+ than in its absence for both factors IX and IXa; the half-maximal effect was observed at approximately 300 microM Ca2+.
(20) This was verified with a method for estimation of kon values from thrombin generation curves.
Meet
Definition:
(v. t.) To join, or come in contact with; esp., to come in contact with by approach from an opposite direction; to come upon or against, front to front, as distinguished from contact by following and overtaking.
(v. t.) To come in collision with; to confront in conflict; to encounter hostilely; as, they met the enemy and defeated them; the ship met opposing winds and currents.
(v. t.) To come into the presence of without contact; to come close to; to intercept; to come within the perception, influence, or recognition of; as, to meet a train at a junction; to meet carriages or persons in the street; to meet friends at a party; sweet sounds met the ear.
(v. t.) To perceive; to come to a knowledge of; to have personal acquaintance with; to experience; to suffer; as, the eye met a horrid sight; he met his fate.
(v. t.) To come up to; to be even with; to equal; to match; to satisfy; to ansver; as, to meet one's expectations; the supply meets the demand.
(v. t.) To come together by mutual approach; esp., to come in contact, or into proximity, by approach from opposite directions; to join; to come face to face; to come in close relationship; as, we met in the street; two lines meet so as to form an angle.
(v. t.) To come together with hostile purpose; to have an encounter or conflict.
(v. t.) To assemble together; to congregate; as, Congress meets on the first Monday of December.
(v. t.) To come together by mutual concessions; hence, to agree; to harmonize; to unite.
(n.) An assembling together; esp., the assembling of huntsmen for the hunt; also, the persons who so assemble, and the place of meeting.
(1) King also described how representatives of every country at this month's G7 meeting in Canada seemed to be relying on an export-led recovery to revive their economies.
(2) Biden will meet with representatives from six gun groups on Thursday, including the NRA and the Independent Firearms Owners Association, which are both publicly opposed to stricter gun-control laws.
(3) "Britain needs to be in the room when the euro countries meet," he said, "so that it can influence the argument and ensure that what the 17 do will not damage the market or British interests.
(4) I said: ‘Apologies for doing this publicly, but I did try to get a meeting with you, and I couldn’t even get a reply.’ And then I had a massive go at him – about everything really, from poverty to uni fees to NHS waiting times.” She giggles again.
(5) Proving that not all teens are content with being part of a purely digital community, Adele Mayr attended a YouTube meet-up in London’s Hyde Park.
(6) David Cameron last night hit out at his fellow world leaders after the G8 dropped the promise to meet the historic aid commitments made at Gleneagles in 2005 from this year's summit communique.
(7) Amid the passionate discussion at the NDA meeting, the two women began to develop a plan.
(8) He was very touched that President Nicolas Sarkozy came out to the airport to meet us, even after Madiba retired.
(9) The committee reviewed the history, original intent, current purpose, and effectiveness of meetings held on the unit; when problems were identified, suggestions for change were formulated.
(10) Whereas the growth and division of normal cells is carefully regulated to meet the needs of the body, tumor cells proliferate autonomously and continually, eventually interfering with and destroying the functions of normal tissue.
(11) A Palestinian delegation was to hold truce talks on Sunday in Cairo with senior US and Egyptian officials, but Israel has said it sees no point in sending its negotiators to the meeting, citing what it says are Hamas breaches of previous agreed truces.
(12) The company said it was on track to meet forecasts for annual profit of about £110m.
(13) Johnson said the move would save businesses £350m from not having to meet the more exacting standards, which will now only have to be met by buses.
(14) But on June 29, 2011, Lois G Lerner, who heads the IRS division that oversees tax-exempt organizations, learned at a meeting that groups were being targeted, according to the watchdog's report.
(15) In April 1986, magnetic resonance imaging (MRI) of the thorax and shoulder girdle was presented to the 99th Annual Meeting of the American Association of Anatomists.
(16) Analysis of official registers reveals the 38 companies in the first wave of the initiative – more than two-thirds of which are based overseas – have collectively had 698 face-to-face meetings with ministers under the current government, prompting accusations of an over-cosy relationship between corporations and ministers.
(17) In Study 1, the Luria-Nebraska Neuropsychological Battery (LNNB) was administered to samples of patients meeting Research Diagnostic Criteria (RDC) for schizodepressive disorder, major depressive disorder or schizophrenia, and to a normal control group.
(18) Children and adopters are encouraged to meet with foster carers after placement to show the child they are well.
(19) He said he was appalled by the player's accusations and plans to meet with Martin on Wednesday at an undisclosed location.
(20) The UN should "be able to meet a much higher standard in fulfilling its protection and humanitarian responsibilities", it says.