(1) The abietic type of acids had a more pronounced antibacterial activity than the pimaric and labdane acids when the disc diffusion method was used but there was no inhibition of growth of Gram-negative bacteria.
(2) The antiproliferative activity of two nitrogenous labdane cytotoxic substances from Lissoclinum voeltzkowi Michaelson (Urochordata), dichlorolissoclimide (P2) and chlorolissoclimide (P1), was studied in vitro on a continuous human non-small-cell bronchopulmonary carcinoma line (NSCLC-N6) at the cell cycle level.
(3) The effects of the diterpene sclareol glycol (SG) of the labdane family on some dopamine (DA) related behavior (locomotor activity in mice, apomorphine-induced stereotypy in mice and rats, and haloperidol-induced catalepsy in rats) were studied.
(4) The microbial metabolism of sclareol (1), a labdane diterpene ditertiary alcohol, was studied.
(5) The concentrations of these labdane diterpenes required to elicit a 50% inhibition of the cytochrome P-450 dependent steroid hydroxylase activity in the insect tissues ranged from approximately 5 x 10(-6) to 5 x 10(-4) M.
(6) Forskolin is a diterpene of the labdane family which activates adenylate cyclase.
(7) Sclareol glycol (SG) is a semisynthetic diterpene of the labdanic group.
(8) The effects of a reversible activator of adenylate cyclase sclareol glycol (SG), a semisynthetic diterpene of the labdane family, on the aggressive behavior induced by a high dose of clonidine in mice were studied.
(9) Bioassay-directed fractionation of the active extract led to the isolation of three labdane-type diterpene acids, scoparic acid A [1] [6-benzoyl-12-hydroxy-labda-8(17), 13-dien-18-oic acid], scoparic acid B [2] [6-benzoyl-14,15-dinor-13-oxo-8(17)-labden-18-oic acid], and scoparic acid C [3] [6-benzoyl-15-nor-14-oxo-8(17)-labden-18-oic acid], the structures of which were established by spectral means, including X-ray analysis.
(10) The effects of the diterpene sclareol glycol (SG) of the labdane family on convulsive seizures induced by pentylenetetrazole (PTZ), picrotoxin and bicuculline in mice were studied.
(11) A new labdane diterpene, prehispanolone LC-5504, namely 9 alpha, 13R,15,16-diepoxy-labdane-14-en-7-one, had been isolated.
(12) This labdanic derivative was identified on the basis of spectroscopic data and is biologically active against the promastigote Leishmania donovani donovani.
(13) It was identified as 7 alpha-methoxy-3a, 10b-dimethyl-1, 2, 3, 3a alpha, 5a alpha, 7, 10b beta, 10c alpha-octahydro-4H, 9H-furo[2', 3', 4': 4, 5]naphthol[2, 1-c]pyran-4, 9-dione, a labdane-derived compound known as antibiotic LL-Z1271 alpha.
(14) The effects of the diterpene sclareol glycol (SG) of the labdane family on rectal body temperature in rats were studied.
(15) Using pentylenetetrazol (PTZ) in subconvulsant doses, it was found that the semisynthetic diterpene sclareol glycol (SG) from the labdane family of diterpenes at a dose well below the lethal dose, although not being convulsant, had a proconvulsant action in mice.
Structural
Definition:
(a.) Of or pertaining to structure; affecting structure; as, a structural error.
(a.) Of or pertaining to organit structure; as, a structural element or cell; the structural peculiarities of an animal or a plant.
Example Sentences:
(1) The findings indicate that there is still a significant incongruence between the value structure of most family practice units and that of their institutions but that many family practice units are beginning to achieve parity of promotion and tenure with other departments in their institutions.
(2) The influence of the various concepts for the induction of lateral structure formation in lipid membranes on integral functional units like ionophores is demonstrated by analysing the single channel current fluctuations of gramicidin in bimolecular lipid membranes.
(3) We have determined the genomic structure of the fosB gene and shown that it consists of 4 exons and 3 introns at positions also found in the c-fos gene.
(4) Structure assignment of the isomeric immonium ions 5 and 6, generated via FAB from N-isobutyl glycine and N-methyl valine, can be achieved by their collision induced dissociation characteristics.
(5) The fine structure of neurofibrillary tangles in the hippocampal gyrus, substantia nigra, pontine nuclei and locus coeruleus of the brain was postmortem studied in a case of progressive supranuclear palsy.
(6) Life expectancy and the infant mortality rate are considered more useful from an operational perspective and for comparisons than is the crude death rate because they are not influenced by age structure.
(7) It has been generally believed that the ligand-binding of steroid hormone receptors triggers an allosteric change in receptor structure, manifested by an increased affinity of the receptor for DNA in vitro and nuclear target elements in vivo, as monitored by nuclear translocation.
(8) Immunocytochemistry was used to visualize cytoskeletal structures and to assay selective disruption of neurofilaments by acrylamide.
(9) The quaternary structure of ribonucleotide reductase of Escherichia coli was investigated, with the use of purified B1 and B2 proteins and bifunctional cross-linking agents.
(10) Structural peculiarities in tubulin polymorphism are considered.
(11) We report a series of experiments designed to determine if agents and conditions that have been reported to alter sodium reabsorption, Na-K-ATPase activity or cellular structure in the rat distal nephron might also regulate the density or affinity of binding of 3H-metolazone to the putative thiazide receptor in the distal nephron.
(12) It is likely that trunk mobility is necessary to maintain integrity of SI joint and that absence of such mobility compromises SI joint structure in many paraplegics.
(13) Fluorination with [18F]acetylhypofluorite yields 6-[18F]fluoro-L-dopa with 95% radiochemical purity; fluorination of the same substrate with [18F]F2 yields a mixture of all three structural isomers in a ratio of 70:16:14 for 6-, 5-, and 2-fluoro compounds.
(14) But the wounding charge in 2010 has become Brown's creation of a structural hole in the budget, more serious than the cyclical hit which the recession made in tax receipts, at least 4% of GDP.
(15) The aetiological factors concerned in the production of paraumbilical and epigastric hernias have been reviewed along structural--functional lines.
(16) The disassembly of the synthetase complex is consistent with the structural model of a heterotypic multienzyme complex and suggests that the complex formation is due to the specific intermolecular interactions among the synthetases.
(17) In addition to the phase diagrams reported here for these two binary mixtures, a brief theoretical discussion is given of other possible phase diagrams that may be appropriate to other lipid mixtures with particular consideration given to the problem of crystalline phases of different structures and the possible occurrence of second-order phase transitions in these mixtures.
(18) The structures of 1 and 2 were established mainly on the basis of nmr spectroscopic data.
(19) Determination of the primary structure for factor V has provided the basis for examination of structure-function relationships.
(20) Aside from these characteristic findings of HCC, it was important to reveal the following features for the diagnosis of well differentiated type of small HCC: variable thickening or distortion of trabecular structure in association with nuclear crowding, acinar formation, selective cytoplasmic accumulation of Mallory bodies, nuclear abnormalities consisting of thickening of nucleolus, hepatic cords in close contact with bile ducts or blood vessels, and hepatocytes growing in a fibrous environment.