(superl.) Exceeding most other things of like kind in bulk, capacity, quantity, superficial dimensions, or number of constituent units; big; great; capacious; extensive; -- opposed to small; as, a large horse; a large house or room; a large lake or pool; a large jug or spoon; a large vineyard; a large army; a large city.
(superl.) Abundant; ample; as, a large supply of provisions.
(superl.) Full in statement; diffuse; full; profuse.
(superl.) Having more than usual power or capacity; having broad sympathies and generous impulses; comprehensive; -- said of the mind and heart.
(superl.) Free; unembarrassed.
(superl.) Unrestrained by decorum; -- said of language.
(superl.) Prodigal in expending; lavish.
(superl.) Crossing the line of a ship's course in a favorable direction; -- said of the wind when it is abeam, or between the beam and the quarter.
(adv.) Freely; licentiously.
(n.) A musical note, formerly in use, equal to two longs, four breves, or eight semibreves.
Example Sentences:
(1) For some time now, public opinion polls have revealed Americans' strong preference to live in comparatively small cities, towns, and rural areas rather than in large cities.
(2) Simplicity, high capacity, low cost and label stability, combined with relatively high clinical sensitivity make the method suitable for cost effective screening of large numbers of samples.
(3) The rise of malaria despite of control measures involves several factors: the house spraying is no more accepted by a large percentage of house holders and the alternative larviciding has only a limited efficacy; the houses of American Indians have no walls to be sprayed; there is a continuous introduction of parasites by migrants.
(4) These eight large plasmids had indistinguishable EcoRI restriction patterns.
(5) The adjacent gauge was separated from the ischemic segment by one large nonoccluded diagonal branch of the left anterior descending artery.
(6) IT can, therefore, be excluded almost with certainty that the meat would contain such large amounts of hormone residues.
(7) The small units described here could be inhibitory interneurons which convert the excitatory response of large units into inhibition.
(8) These studies, in addition to demonstrating that the placenta contains TRH deamidase activity, suggest that losses of fetal TRH through the placenta are not large.
(9) At the time, with a regular supply of British immigrants arriving in large numbers in Australia, Biggs was able to blend in well as "Terry Cook", a carpenter, so well in fact that his wife, Charmian, was able to join him with his three sons.
(10) Theresa May signals support for UK-EU membership deal Read more Faull’s fix, largely accepted by Britain, also ties the hands of national governments.
(11) Large gender differences were found in the correlations between the RAS, CR, run frequency, and run duration with the personality, mood, and locus of control scores.
(12) One patient with a large fistula angiographically had no oximetric evidence of shunt at cardiac catheterization.
(13) Their contour lengths varied from 0.28 to 51 micron, but unlike in the case of maize, a large difference was not observed in the distribution of molecular classes greater than 1.0 micron between N and S cytoplasms of sugar beet.
(14) The region containing the injection stop signal (iss) has been cloned and sequenced and found to contain numerous large repeats and inverted repeats which may be part of the iss.
(15) Chloroquine induced large cytoplasmic vacuoles, whereas the other drugs (quinacrine, 4,4'-diethylaminoethoxyhexestrol, chlorphentermine, iprindole, 1-chloro-amitriptyline, clomipramine) caused formation of lamellated or crystalloid inclusions as usually seen in drug-induced lipidosis.
(16) The leukemic T-cells in two patients with chronic lymphocytic leukemia (CLL) had specific features of large granular lymphocytes (LGL), and those in two patients with acute lymphocytic leukemia (ALL) had L2 morphologic characteristics.
(17) Of the 622 people interviewed, a large proportion (30.5%) believed that the first deciduous tooth should erupt between the age of 5-7 months; the next commonly mentioned time of tooth eruption was 7-9 months of age; and 50.3% of the respondents claimed to have seen a case of prematurely erupted primary teeth.
(18) She was not aware that it was an assassination attempt by alleged foreign agents.” If at least one of the women thought the killing was part of an elaborate prank, it might explain the “LOL” message emblazoned in large letters one of the killers t-shirts.
(19) The ratios in both groups were also compared with the ratios of a large group of normal subjects evaluated in a population survey.
(20) Our results show that large complex lipid bodies and extensive accumulations of glycogen are valuable indicators of a functionally suppressed chief cell in atrophic parathyroid glands.
Major
Definition:
(a.) Greater in number, quantity, or extent; as, the major part of the assembly; the major part of the revenue; the major part of the territory.
(a.) Of greater dignity; more important.
(a.) Of full legal age.
(a.) Greater by a semitone, either in interval or in difference of pitch from another tone.
(a.) An officer next in rank above a captain and next below a lieutenant colonel; the lowest field officer.
(a.) A person of full age.
(a.) That premise which contains the major term. It its the first proposition of a regular syllogism; as: No unholy person is qualified for happiness in heaven [the major]. Every man in his natural state is unholy [minor]. Therefore, no man in his natural state is qualified for happiness in heaven [conclusion or inference].
(a.) A mayor.
Example Sentences:
(1) In contrast, resting cells of strain CHA750 produced five times less IAA in a buffer (pH 6.0) containing 1 mM-L-tryptophan than did resting cells of the wild-type, illustrating the major contribution of TSO to IAA synthesis under these conditions.
(2) With NaCl as the major constituent of the bathing solution (potassium-free pipette and external solutions) the reversal potential (Er) of the noradrenaline-evoked current was about 0 mV.
(3) After 4 to 6 hours of recirculation, accumulation of vasoactive amine, 5-hydroxytryptamine, its major metabolite, 5-hydroxyindole acetic acid, and its precursor amino acid, tryptophan were detected.
(4) The major treatable risk factors in thromboembolic stroke are hypertension and transient ischemic attacks (TIA).
(5) The promoters of the adenovirus 2 major late gene, the mouse beta-globin gene, the mouse immunoglobulin VH gene and the LTR of the human T-lymphotropic retrovirus type I were tested for their transcription activities in cell-free extracts of four cell lines; HeLa, CESS (Epstein-Barr virus-transformed human B cell line), MT-1 (HTLV-I-infected human T cell line without viral protein synthesis), and MT-2 (HTLV-I-infected human T cell line producing viral proteins).
(6) The data suggest that major differences may exist between ruminants and non-ruminants in the response of liver metabolism both to lactation per se and to the effects of growth hormone and insulin.
(7) Then a handful of organisers took a major bet on the power of people – calling for the largest climate change mobilisation in history to kick-start political momentum.
(8) This finding is of major importance for persons treated with diltiazem who engage in sport.
(9) Blatter requires a two-thirds majority of the 209 voters to triumph in the opening round, with a simple majority required if it goes to a second round.
(10) Further analysis with two other synthetic peptides (212Cys to 222Glu and Cys X 221Ile to 236Glu) indicated that the dodecapeptide Ile-Glu-Phe-Gln-Lys-Asn-Asn-Arg-Leu-Leu-Glu mimicked either the whole or a major part of the neutralization epitope.
(11) Inadequate treatment, caused by a lack of drugs and poorly trained medical attendants, is also a major problem.
(12) Even so, amputation of fifteen extremities and four other major excisions were required in twelve patients.
(13) In this study, standby and prophylactic patients had comparable success and major complication rates, but procedural morbidity was more frequent in prophylactic patients.
(14) These major departmental transformations are being run in isolation from each other.
(15) Epidemiological studies on low risks involve a number of major methodological difficulties.
(16) Given Australia’s number one position as the worst carbon emitter per capita among major western nations it seems hardly surprising that islanders from Fiji, Samoa, Vanuatu and other small island developing states have been turning to Australia with growing exasperation demanding the country demonstrate an appropriate response and responsibility.
(17) The time-course and dose-response for this modification of pp60c-src paralleled PDGF-induced increases in phosphorylation of pp36, a major cellular substrate for several tyrosine-specific protein kinases.
(18) The degree of increase in Meth responsiveness elicited by the initial provocation is a major factor in determining the airway response to a subsequent HS challenge.
(19) On the other hand, the majority of gynecologic patients with pelvic infections are young and healthy.
(20) Confidence is the major prerequisite for a doctor to be able to help his seriously ill patient.