(superl.) Exceeding most other things of like kind in bulk, capacity, quantity, superficial dimensions, or number of constituent units; big; great; capacious; extensive; -- opposed to small; as, a large horse; a large house or room; a large lake or pool; a large jug or spoon; a large vineyard; a large army; a large city.
(superl.) Abundant; ample; as, a large supply of provisions.
(superl.) Full in statement; diffuse; full; profuse.
(superl.) Having more than usual power or capacity; having broad sympathies and generous impulses; comprehensive; -- said of the mind and heart.
(superl.) Free; unembarrassed.
(superl.) Unrestrained by decorum; -- said of language.
(superl.) Prodigal in expending; lavish.
(superl.) Crossing the line of a ship's course in a favorable direction; -- said of the wind when it is abeam, or between the beam and the quarter.
(adv.) Freely; licentiously.
(n.) A musical note, formerly in use, equal to two longs, four breves, or eight semibreves.
Example Sentences:
(1) For some time now, public opinion polls have revealed Americans' strong preference to live in comparatively small cities, towns, and rural areas rather than in large cities.
(2) Simplicity, high capacity, low cost and label stability, combined with relatively high clinical sensitivity make the method suitable for cost effective screening of large numbers of samples.
(3) The rise of malaria despite of control measures involves several factors: the house spraying is no more accepted by a large percentage of house holders and the alternative larviciding has only a limited efficacy; the houses of American Indians have no walls to be sprayed; there is a continuous introduction of parasites by migrants.
(4) These eight large plasmids had indistinguishable EcoRI restriction patterns.
(5) The adjacent gauge was separated from the ischemic segment by one large nonoccluded diagonal branch of the left anterior descending artery.
(6) IT can, therefore, be excluded almost with certainty that the meat would contain such large amounts of hormone residues.
(7) The small units described here could be inhibitory interneurons which convert the excitatory response of large units into inhibition.
(8) These studies, in addition to demonstrating that the placenta contains TRH deamidase activity, suggest that losses of fetal TRH through the placenta are not large.
(9) At the time, with a regular supply of British immigrants arriving in large numbers in Australia, Biggs was able to blend in well as "Terry Cook", a carpenter, so well in fact that his wife, Charmian, was able to join him with his three sons.
(10) Theresa May signals support for UK-EU membership deal Read more Faull’s fix, largely accepted by Britain, also ties the hands of national governments.
(11) Large gender differences were found in the correlations between the RAS, CR, run frequency, and run duration with the personality, mood, and locus of control scores.
(12) One patient with a large fistula angiographically had no oximetric evidence of shunt at cardiac catheterization.
(13) Their contour lengths varied from 0.28 to 51 micron, but unlike in the case of maize, a large difference was not observed in the distribution of molecular classes greater than 1.0 micron between N and S cytoplasms of sugar beet.
(14) The region containing the injection stop signal (iss) has been cloned and sequenced and found to contain numerous large repeats and inverted repeats which may be part of the iss.
(15) Chloroquine induced large cytoplasmic vacuoles, whereas the other drugs (quinacrine, 4,4'-diethylaminoethoxyhexestrol, chlorphentermine, iprindole, 1-chloro-amitriptyline, clomipramine) caused formation of lamellated or crystalloid inclusions as usually seen in drug-induced lipidosis.
(16) The leukemic T-cells in two patients with chronic lymphocytic leukemia (CLL) had specific features of large granular lymphocytes (LGL), and those in two patients with acute lymphocytic leukemia (ALL) had L2 morphologic characteristics.
(17) Of the 622 people interviewed, a large proportion (30.5%) believed that the first deciduous tooth should erupt between the age of 5-7 months; the next commonly mentioned time of tooth eruption was 7-9 months of age; and 50.3% of the respondents claimed to have seen a case of prematurely erupted primary teeth.
(18) She was not aware that it was an assassination attempt by alleged foreign agents.” If at least one of the women thought the killing was part of an elaborate prank, it might explain the “LOL” message emblazoned in large letters one of the killers t-shirts.
(19) The ratios in both groups were also compared with the ratios of a large group of normal subjects evaluated in a population survey.
(20) Our results show that large complex lipid bodies and extensive accumulations of glycogen are valuable indicators of a functionally suppressed chief cell in atrophic parathyroid glands.
Serious
Definition:
(a.) Grave in manner or disposition; earnest; thoughtful; solemn; not light, gay, or volatile.
(a.) Really intending what is said; being in earnest; not jesting or deceiving.
(a.) Important; weighty; not trifling; grave.
(a.) Hence, giving rise to apprehension; attended with danger; as, a serious injury.
Example Sentences:
(1) This should not be a serious limitation to the application of the RIA in the detection of venous thrombosis.
(2) But the wounding charge in 2010 has become Brown's creation of a structural hole in the budget, more serious than the cyclical hit which the recession made in tax receipts, at least 4% of GDP.
(3) "There is a serious risk that a deal will be agreed between rich countries and tax havens that would leave poor countries out in the cold.
(4) Confidence is the major prerequisite for a doctor to be able to help his seriously ill patient.
(5) No report can be taken seriously if its authors weren’t even in Yemen to conduct investigations.” The UN team was not given permission to enter the country.
(6) The decline in the frequency of serious complications was primarily due to a decrease in the proportion of patients with open fractures treated with plate osteosynthesis from nearly 50% to 19%.
(7) Vancomycin is the antibiotic of choice for serious MRSA infections; PRPs and cephalosporins generally are not effective.
(8) An age- and education-matched group of women with no family history of FXS was asked to predict the seriousness of problems they might encounter were they to bear a child with a handicapping condition.
(9) The most serious complications following operative treatment are retained bile duct calculi (2.8%), wound infection and biliary fistulae.
(10) Guardian Australia reported last week that morale at the national laboratory had fallen dramatically, with one in three staff “seriously considering” leaving their jobs in the wake of the cuts.
(11) In case of biliary and pancreatic duct obstruction with pure pancreatic reflux, both oedema and inflammatory infiltrations were evident, whereas, in the presence of biliary reflux too, more serious histological features were detected.
(12) Autopsy revealed serious somatic diseases (stenosis of the ileum in two cases and brain tumor in one); their symptoms had been largely overlapped by those of anorexia nervosa.
(13) The above treatment is tolerated well and no serious side effects have been observed.
(14) This observation seriously challenges the hypothesis that SCE cancellation results as a consequence of persistence of the lesions induced by these agents.
(15) Earlier recognition of foul-smelling mucoid discharge on the IUD tail, or abnormal bleeding, or both, as a sign of early pelvic infection, followed by removal of the IUD and institution of appropriate antibiotic therapy, might prevent the more serious sequelae of pelvic inflammation.
(16) Left ventricular rupture is a serious complication of mitral valve replacement.
(17) Other serious complications were reservoir perforation during catheterisation in 3 and development of stones in the reservoir in 2 patients.
(18) For application to mammalian cells, however, two serious problems require resolution: (1), correction of TPP+ binding to intracellular constituents and (2), estimation of the considerable TPP+ accumulation in mitochondria.
(19) At least 1 episode of serious infection occurred in 34 of the 60 adult patients and 25 of the 30 children.
(20) These high Danish rates seem to reflect the true prevalence and incidence in the less serious types of progressive muscular dystrophy, probably because the Danish health system with free medical care and easy access to specialized hospital departments makes it possible to identify all cases of progressive muscular dystrophy.