(n.) A long, slender rope made of hemp or strips of hide, esp. one with a noose; -- used as a lasso for catching cattle, horses, etc., and for picketing a horse so that he can graze without wandering.
(v. t.) To secure with a lariat fastened to a stake, as a horse or mule for grazing; also, to lasso or catch with a lariat.
Example Sentences:
(1) The RNA-catalysed self-splicing reaction of group II intron RNA is assumed to proceed by two consecutive transesterification steps, accompanied by lariat formation.
(2) Two other discrete RNA species produced during splicing in vitro may represent reaction intermediates: free, linear exon 1 and a form of the intron lariat extending beyond the 3' splice site to include exon 2.
(3) Specifically, StAg splicing uses either of two lariat branch points, one of which is located only 4 nucleotides from the 3' splice site.
(4) The deoxyribose rings towards the 5' terminus exist predominantly in the S form (2'-endo-3'-exo) while residues on or adjacent to the 2' branch site in the eventual lariat structure [A(6) of TACTAAC] show more N-character (3'endo-2'-exo).
(5) Third, the lariat IVS is linearized after the release of the small RNP.
(6) Fewer branches were found in the poly A(-) RNAs of the nucleus and of late adenovirus transcripts suggesting that excised lariat introns do not accumulate in vivo.
(7) The internal exon was missing from the spliced product and together with two flanking introns was included in a large lariat structure.
(8) We also find linear IVS1 and a randomly nicked lariat, the latter probably being made during RNA isolation.
(9) The site of branchpoint formation was localized by debranching the Drosophila lariat with mammalian (HeLa) cell debranching enzyme and by P1 and T2 nuclease analysis.
(10) Processing of dead-end lariat intermediates to mRNA correlates with base pairing between U5 and the first two bases in exon 2.
(11) First, the pre-mRNA is cleaved at the 5' splice site and a branched (lariat) intermediate is formed.
(12) Here we demonstrate that 5' SS cleavage and lariat formation take place in vitro in the absence of the 3' SS and much of the 3' junction.
(13) Sequence analysis of these genomic clones revealed that the two short segments specific for the two mRNAs are tandemly arranged in a genomic sequence and form exonic sequences equipped with AG and GT sequences on their 5' and 3' ends, respectively, and the putative consensus sequences for the lariat formation.
(14) Furthermore, incubation of oocyte RNA with a HeLa cell extract with lariat debranching activity converted the small RNA to a class that now migrated as less than or equal to 140 nucleotides in length in 8% gels, consistent with the size of the linear intraleader intron.
(15) These results suggest that during the normal in vitro splicing reaction the 2',5'-phosphodiester bond of RNA lariats is protected from cleavage by the lariat debranching activity.
(16) Addition of fraction Ia to the combination of Ib and II resulted in the formation of spliced RNA and the intron lariat.
(17) The incubation of two of the fractions (Ib and II) in the presence of ATP resulted in cleavage of precursor mRNA at the 5' splice site and formation of the intron-exon lariat.
(18) Pre-mRNAs lacking the authentic branch point sequence are accurately spliced in vitro; processing of the mutant pre-mRNAs generates RNA lariats due to the activation of cryptic branch points within IVS1.
(19) In addition, the data strongly reinforce the importance of the distance constraint for lariat formation.
(20) Instead of inching my way along a busy B-road in the drizzle, wearing a hard hat and a hi-vis jacket, I was on a black-and-white pony in the wild west, riding alongside men with names like Cody who talked kinda slow and carried lariats on their saddles.
Roper
Definition:
(n.) A maker of ropes.
(n.) One who ropes goods; a packer.
(n.) One fit to be hanged.
Example Sentences:
(1) Roper, who was not in her post at the time, told the hearing: “[FCO staff] spent a lot of time talking about the details of the case.
(2) Far better then, for the movie, to give Roper a billionaire’s island in the sun with a palatial Gatsby -style villa at its centre and a sprinkling of cottages for his underlings and protectors.
(3) According to the Roper Center for Public Opinion Research at Cornell University, women favored the Democratic candidate in 2012 by 11 points, 2008 by 13, 2004 by three, and 2000 by 10 points.
(4) The results of calorie balance studies were compared with the roper data of FS infants in I trimester and II semester of life, which were described in our previous paper.
(5) Does she realise, for instance, that in her film Richard Roper goes down winning ?
(6) I went into the Roper archives to examine races where no incumbent was running for re-election, and only Al Gore, at around 55% in early 1997 for the 2000 run, comes anywhere close.
(7) At moments it almost seems so: as if Roper actually enjoys being a partner in his own destruction, just for the pleasure of pairing with someone as intelligent and ruthless as himself; almost as if he’s a little in love with his own executioner.
(8) I dug through the Roper archives and found three pollsters with favorable ratings taken during the final week of the campaign dating back to at least 1992.
(9) This paper gives an overview of the issues surrounding the development and use of models and presents research data which indicates that one model (Roper, Logan & Tierney's Activities of Living) is problematic in the long-term care of the elderly.
(10) I went back in the Roper archive and plotted the incumbent's approval rating against the favorability gap in the final months since 1980.
(11) Laurie, who won best performance by an actor in a limited TV series for playing arms dealer Richard Roper in The Night Manager, said: “I suppose it’s made more amazing by the fact that I’ll be able to say I won this at the last ever Golden Globes.” “I don’t mean to be gloomy, it’s just that it has the words ‘Hollywood,’ ‘Foreign’ and ‘Press’ in the title.
(12) We compared these data with similar data collected by the Roper Organization in the 1970s and found that smokers today are less likely to smoke inside public places.
(13) He was a gent, I could only mumble some nonsense about smelling the flowers.” Also notable in the picture is the understudy for goalkeeper Ivan Katalinic, George and Mildred Roper’s next door neighbour, Jeffrey Fourmile .
(14) Put another way, are Pine and Roper mutually aware of their purposes from the very start?
(15) Maybe that’s because Laurie’s Roper has been enter taining us for so long with his cool, his wit, his urbanity and his sheer wickedness that we don’t want to let him go.
(16) Hugh Trevor-Roper denounced it as this "meretricious, misleading work".
(17) An avenue of research suggested by Patrick Trevor-Roper's 'inquiry into the influence of defective vision on art and character' provides a possible solution to an art-historical problem.
(18) The only people who would have the authority to murder a high profile prisoner in defiance of the president would be the intelligence service, the mukhabarat.” Galloway added: “I haven’t heard from Damascus since then so I’m definitely off their Christmas card list.” Asked whether he knew that the former leader of the BNP, Nick Griffin, was also involved with the Khan family, Galloway said: “I would have been horrified had I been aware.” Earlier, Michael Mansfield QC, for the Khan family, had pressed the head of the Foreign Office’s consular section, Joanna Roper, about whether the department had been sufficiently active in its efforts to secure Dr Khan’s release.
(19) The teaching was supported by appropriate care planning within the Roper et al.
(20) The study is based on the theoretical model presented by Roper et al.