(1) The hisG mutations are of all types (nonsense, frameshift, missense, deletion and leady types), and they map throughout the hisG gene.
Leaky
Definition:
(superl.) Permitting water or other fluid to leak in or out; as, a leaky roof or cask.
(superl.) Apt to disclose secrets; tattling; not close.
Example Sentences:
(1) It is therefore suggested that salt water adaptation triggers a cellular reorganization of the epithelium in such a way that leaky junctions (a low resistance pathway) appear at the apex of the chloride cells.
(2) But this is how we live even before we are forced, through penury to claim: fine dining on stewed leftovers, nursing our one drink on those rare social events, cutting our own hair, patchwork-darned clothes and leaky shoes.
(3) No net synthesis of ATP was demonstrated in leaky vesicles.
(4) Results indicated that the synthesis of both core and pol proteins was concomitantly reduced in these three conditions, which suggested that leaky scanning is the most probable mechanism for pol protein synthesis in vitro.
(5) One possibility is that the membrane of dystrophic muscle is weakened and becomes leaky to Ca2+.
(6) A combination of the leaky-patch and doughnut models may represent the most likely mechanism.
(7) Interstitial cystitis patients were shown to have a leaky epithelium by placing a solution of concentrated urea into the bladder and measuring the absorption.
(8) The affinity labeling was intensified when resealed vesicles were made leaky by freezing or ultrasonication, suggesting that the poly(A) binding proteins are accessible from the nucleoplasmic but not the cytoplasmic face of the envelope.
(9) Increases in permeability of the hamster cheek pouch were quantitated by the formation of microvascular leaky sites.
(10) This alteration in Ca2+ pump activity is not due to (i) non-specific effects of vesicle preparation in the two animal groups, (ii) increased leakiness to Ca2+, or (iii) any apparent alteration in permeability of the membrane to K+ and Cl-.
(11) Acetyl phosphate is hydrolyzed by the calcium ATPase of leaky sarcoplasmic reticulum vesicles from rabbit skeletal muscle with Km = 6.5 mM and kcat = 7.9 s-1 in the presence of 100 microM calcium (180 mM K+, 5 mM MgSO4, pH 7.0, 25 degrees C).
(12) Analysis using an SV40-derived vector indicates that the transcription termination site in the HBV genome is also leaky for X gene transcription when a heterologous promoter initiates the transcription.
(13) The ability of the position 236 mutants to grow better than the parent in the presence of low concentrations of thiodigalactoside appears to be due to a decrease in affinity for this particular sugar rather than a generalized defect in H+ leakiness.
(14) These observations confirm previously published data and add further support to the proposition that channeling of glycolytic intermediates occurs in DSP cells but is of the "leaky" type.
(15) they were prominent around the leaky vessels in the grey matter, in the subpial zone and in the white matter.
(16) The severe and prolonged asphyxia rendered the blood-brain barrier leaky to the albumin tracer Evans blue.
(17) A gpp spoT double mutant, constructed by employing a leaky spoT mutation, was found to have a slower rate of pppGpp degradation than the gpp mutant alone.
(18) Administration of histamine (10(-4) M) to the exposed brain surface for 5 min increased the number of leaky sites to Na-fluorescein and FITC-albumin 3.2 and 3.6 times, respectively.
(19) Mutant strains of E. amylovora, selected for resistance to each separate antibacterial agent (or to all three of them), showed a direct correlation (in all but the novobiocin-resistant mutant) between drug resistance and reduced periplasmic leakiness.
(20) The model is a simple network consisting basically of (1) two subunits that have receptive fields with a center-surround organization and an adaptational gain control, (2) a lateral inhibitory pathway, (3) a site of nonlinear interaction, followed by (4) a leaky temporal integrator.