(1) Gamma-irradiated splenic homogenates of armadillos infected with M. leprae proved sterile by conventional tests and media.
(2) The effect of mycobacterial phenolic glycolipids from Mycobacterium leprae, M. bovis BCG, and M. kansasii on in vitro proliferative responses by human blood mononuclear cells from healthy BCG vaccinees was investigated.
(3) In two there was invasion by Mycobacterium leprae into the brain tissue, with neuronal cells and glial cells containing intracellular bacilli.
(4) Four tested TLC display strikingly different antigen recognition patterns when tested against a number of other mycobacterial antigens; one TLC so far recognizes only M. leprae antigens.
(5) In order to study the polyspecificities of human autoantibodies expressed during infection with Mycobacterium leprae we prepared human monoclonal antibodies derived from the fusion of peripheral blood lymphocytes of a patient with lepromatous leprosy to the human lymphoblastoid line GM 4672.
(6) The 18-kilodalton (kDa) antigen of Mycobacterium leprae was expressed as a fusion protein with a 2-kDa leader peptide and used in proliferation assays with peripheral blood cells.
(7) Consistently higher antigen positivity rates for the 35-, 12-, and 30- to 40-kDa components of M. leprae were observed in lepromatous leprosy patients than in tuberculoid leprosy patients.
(8) The results suggest that macrophages from patients with either tuberculoid or lepromatous leprosy are not by themselves capable of lysing live M. leprae.
(9) In the nine index leprosy cases the pattern of responsiveness to the purified antigens paralleled that to whole sonicates from M. leprae and BCG.
(10) There was strong correlation between the responses to BCG and M. leprae and the responses to the two antigens.
(11) It is probably caused by B cell stimulation by antigenic complex of Mycobacterium leprae plus autologous tissue, along with a dysfunction of the T-suppressor lymphocytes.
(12) This report describes the use of a recombinant yeast expression vector to synthesize and secrete the Mycobacterium leprae 18 kDa antigenic protein.
(13) The observed changes in enzymatic activities were not due to bacterial enzymes and so can be related to tissue damage caused by M. leprae.
(14) Infections of mice with Mycobacterium leprae in one rear foot pad immunized them against a second infection in the other rear foot pad.
(15) In vitro attempts to demonstrate local activated macrophages in the foot pads of M. leprae infected mice failed, but, because of the technical problems encountered, do not preclude their presence.
(16) NTLR were killed at intervals; the M. leprae were counted and passed to mice.
(17) No substantiated claim was made concerning the in vitro growth of M. leprae and the application of the tissue culture technique has been equally disappointing.
(18) We propose that such a similarity on the one hand may facilitate the survival of M. leprae in the human host when the antigens are not recognized as "non-self," a situation which seems to occur in lepromatous leprosy, when the patients' tissues are loaded with bacteria virtually without any immune response.
(19) Adherence of Mycobacterium leprae was studied in vitro in monolayer cultures of purified mouse Schwann cells.
(20) When murine macrophages derived from the peritoneal cavities of CBA mice were infected in vitro with M. leprae (Thai-53 strain), intracellular multiplication was observed three weeks after infection.
Lepry
Definition:
(n.) Leprosy.
Example Sentences:
(1) Giovanni Lepri, UNHCR’s assistant representative in Athens, said as many as 300 unaccompanied migrant children were currently being held in detention centres in Greece because children’s homes were overflowing.