(1) The authors have observed 135 dislocations of the tarsus in leprosic feet.
(2) Corollary lymphocyte cultures failed to show any suppression by leprosing of the lymphoproliferative responses to tuberculin.
Scurfy
Definition:
(superl.) Having or producing scurf; covered with scurf; resembling scurf.
Example Sentences:
(1) Scurfy lesions characteristically contain a population of large blastlike cells with round to oval nuclei, a vesicular chromatin pattern, and prominent single nucleoli.
(2) The role of the thymus in the development of fatal lymphoreticular disease in the scurfy mouse was investigated.
(3) The X chromosome-linked scurfy (sf) mutant of the mouse is recognized by the scaliness of the skin from which the name is derived and results in death of affected males at about 3-4 weeks of age.
(4) Bone marrow from scurfy mice can reconstitute lethally irradiated, H-2-compatible animals but does not transmit scurfy disease.
(5) Scurfy differs from Wiskott-Aldrich syndrome in that scurfy males are consistently hypogonadal.
(6) We conclude, from these data, that scurfy lesions are mediated by T lymphocytes that mature in an abnormal (sf) thymic environment.
(7) Scurfy (sf), is an X-linked recessive lethal mutation that occurs spontaneously in the C3H mouse.
(8) Characteristic lesions in mice hemi- or homozygous for the X-linked mutation scurfy (sf) include lymphohistiocytic proliferation in the skin and lymphoid organs, Coombs' test-positive anemia, hypergammaglobulinemia, and death by 24 days of age.
(9) Thus, while our findings indicate that scurfy disease may be the result of immune dysfunction, it is not a classic immunodeficiency.
(10) Neonatal thymectomy doubles the life span of scurfy mice, moderates the histologic lesions, and prevents anemia, despite the continued presence of high levels of serum IgG.
(11) The centromere of the X (LGXX) has been tentatively assigned to the end nearest to the scurfy (sf) locus.
(12) Our studies indicate that the phenotype of hemizygous scurfy is not, as has been suggested, a model for human X-linked ichthyosis, but appears to be a disease primarily affecting the lymphoreticular, and possibly the hematopoietic, systems.
(13) Scurfy mice are negative for antinuclear antibodies.
(14) Despite their morphologically aberrant lymphoreticular system, scurfy mice can exist in a conventional environment without evidence of opportunistic infection.
(15) Scurfy (sf) is a spontaneous, sex-linked, recessive mutation that maps to the extreme proximal portion of the X chromosome, about 2 centimorgans from sparse fur (spf).
(16) Raising scurfy mice in a specific-pathogen-free environment does not alter disease expression.