(n.) A cutaneous disease which first appears as blebs or as reddish, shining, slightly prominent spots, with spreading edges. These are often followed by an eruption of dark or yellowish prominent nodules, frequently producing great deformity. In one variety of the disease, anaesthesia of the skin is a prominent symptom. In addition there may be wasting of the muscles, falling out of the hair and nails, and distortion of the hands and feet with destruction of the bones and joints. It is incurable, and is probably contagious.
Example Sentences:
(1) The differential diagnosis is more complex in Hawaii due to the presence of granulomatous diseases such as tuberculosis and leprosy.
(2) Leprosy is an uncommon disease in Saudi population.
(3) Mononuclear phagocytic cells from patients with either principal form of leprosy functioned similarly to normal monocytes in phagocytosis while their fungicidal activity for C. pseudotropicalis was statistically significantly altered and was more evident in the lepromatous than in the tuberculoid type.
(4) Serum levels of vitamins A and E, zinc and iron were determined in healthy control subjects and lepromatous leprosy patients belonging to an eastern state of India.
(5) A rare coincidence of cutaneous Rhinosporidiosis and Lepromatous leprosy is reported.
(6) In order to study the polyspecificities of human autoantibodies expressed during infection with Mycobacterium leprae we prepared human monoclonal antibodies derived from the fusion of peripheral blood lymphocytes of a patient with lepromatous leprosy to the human lymphoblastoid line GM 4672.
(7) The present report is a continuation of our earlier studies on the complex interaction between undernutrition and leprosy.
(8) It is known that the impairment of cell-mediated immunity (CM) exists in lepromatous leprosy patients.
(9) Age specific prevalence rates of leprosy after examining more than 80% of population from these colonies are compared with data derived from normal slums situated elsewhere in the city.
(10) The possible epidemiological significance of these findings for the transmission of leprosy in man is discussed.
(11) Consistently higher antigen positivity rates for the 35-, 12-, and 30- to 40-kDa components of M. leprae were observed in lepromatous leprosy patients than in tuberculoid leprosy patients.
(12) The results suggest that macrophages from patients with either tuberculoid or lepromatous leprosy are not by themselves capable of lysing live M. leprae.
(13) In 83 per cent of cases the nephrotic syndrome was due to minimal change disease, focal segmental glomerulosclerosis, mesangiocapillary glomerulonephritis, membranous usually secondary to tuberculosis or leprosy, was present in only 34 patients.
(14) Histopathologically, the lesions display caseating and noncaseating dermal granulomas that mimic those seen in tuberculosis, tuberculoid leprosy, sarcoidosis, and other diseases.
(15) Leprosy is one of the leading causes of corneal hyposensitivity.
(16) The presence of high anti-EBV antibody titers in lepromatous leprosy suggests that cell-mediated immunity is a significant factor in host response to EBV infection.
(17) Overall in the contacts, 71.7% were Mitsuda positive and 93.6% showed seropositivity, without regard to their age, sex, or leprosy type of their index case.
(18) In the nine index leprosy cases the pattern of responsiveness to the purified antigens paralleled that to whole sonicates from M. leprae and BCG.
(19) When incidence and prevalence of leprosy are low, testing with these antigens would not be cost effective, unless applied to high risk individuals.
(20) The protocol was devised by first evaluating a range of kits in London using a battery of African and non-African sera and then field testing 1455 sera in Malaŵi, which included 184 sera from leprosy patients and 60 sera from syphilis patients to check for cross-reactivity.
Vitiligo
Definition:
(n.) A rare skin disease consisting in the development of smooth, milk-white spots upon various parts of the body.
Example Sentences:
(1) Six patients with spreading vitiligo treated with applications of monobenzone developed a vesicular dermatitis.
(2) Duplicate heparinized blood samples were drawn from 22 subjects; 2 healthy subjects, 1 vitiligo and 19 with thyroid or parathyroid diseases.
(3) Jackson said he suffered from vitiligo, a condition that causes the skin to lose its pigment.
(4) Three patients with malignant melanoma and coexisting vitiligo are described.
(5) Two vitiligo patients were hypergastrinaemic suggesting latent pernicious anaemia.
(6) The psoralen analogs 8-methoxypsoralen (8-MOP) and 4,5',8-trimethylpsoralen (TMP), in combination with ultraviolet light (UVA, 320-400 nm), are potent modulators of epidermal cell growth and differentiation and are commonly used in photochemotherapy of psoriasis and vitiligo.
(7) Since persons with the Down syndrome are predisposed to immunological deficiency in thymus-dependent (T-cell) function, findings from the skin examinations suggest that immunologic factors might contribute to the increased incidence of vitiligo and alopecia areata seen in the Down syndrome.
(8) Association with diseases such as diabetes, vitiligo and hypothyroidism have strengthened the auto-immune nature of this syndrome.
(9) The results of the present study suggest that systemic factors may play a role in the pathogenesis of vitiligo and acquired hypomelanosis guttata.
(10) Psycho- and autonomotropic drugs, acupuncture, and psychotherapeutic conversations were used for the correction of psychologic abnormalities in 49 vitiligo patients, presenting with impaired sociopsychological adaptation and autonomic imbalance.
(11) The data obtained suggest that kynurenine and serotonin pathways of tryptophan metabolism were intensified in vitiligo.
(12) The lysis of human melanocytes by vitiligo patients' sera by two different effector mechanisms provides direct support for the autoimmune hypothesis of human vitiligo.
(13) No significant differences in the results of several immunological examinations (E-RFC, EAC-RFC, EA-RFC, IF, IF-elution) came to light results suggest that the lymphocytes are probably not implied in the pathogenesisof vitiligo.
(14) In three men vitiligo-like skin changes, enlargement of liver and spleen and diffuse goitre (grade II) with increased TSH secretion developed within one to two years of their having started work in a factory producing paratertiary butylphenol.
(15) Vitiligo lesions themselves gave rise to unidentified dendritic cells that survived for 10-15 days without manifesting any growth.
(16) C4 typing by Western blot analysis showed the frequency of the C4A*Q0 allele in the vitiligo patient group to be close to normal.
(17) This culture system will be applied to investigate the basic pathophysiology of vitiligo and other various pigmentary dermatoses.
(18) Vitiliginous achromia with malignant melanoma shows some discrepancies with vitiligo.
(19) A 45 year old Saudi male with poliosis, alopecia areata, vitiligo, anterior uveitis, inflammatory changes in the posterior pole of the retina and paraparesis presented with features of the Vogt-Koyanagi-Harada syndrome, uncontrolled diabetes mellitus and hypothyroidism.
(20) A diabetic patient is described presenting psoriasis, necrobiosis lipoidica diabeticorum, granuloma annulare, and vitiligo and with a history of recurrent erysipelas and mycotic infections.