(a.) Of or pertaining to a particular place, or to a definite region or portion of space; restricted to one place or region; as, a local custom.
(n.) A train which receives and deposits passengers or freight along the line of the road; a train for the accommodation of a certain district.
(n.) On newspaper cant, an item of news relating to the place where the paper is published.
Example Sentences:
(1) The patterns observed were: clusters of granules related to the cell membrane; positive staining localized to portions of the cell membrane, and, less commonly, the whole cell circumference.
(2) A series of human cDNA clones of various sizes and relative localizations to the mRNA molecule were isolated by using the human p53-H14 (2.35-kilobase) cDNA probe which we previously cloned.
(3) The predicted non-Lorentzian line shapes and widths were found to be in good agreement with experimental results, indicating that the local orientational order (called "packing" by many workers) in the bilayers of small vesicles and in multilamellar membranes is substantially the same.
(4) Villagers, including one man who has been left disabled and the relatives of six men who were killed, are suing ABG in the UK high court, represented by British law firm Leigh Day, alleging that Tanzanian police officers shot unarmed locals.
(5) It would be fascinating to see if greater local government involvement in running the NHS in places such as Manchester leads over the longer term to a noticeable difference in the financial outlook.
(6) This scintigraphic localization of osteomyelitis seldom has been reported.
(7) Local embolism, vertebral distal-stump embolism, the dynamics of hemorrhagic infarction and embolus-in-transit are briefly described.
(8) This computer is connected to a fileserver via a local area network and is used exclusively for data acquisition.
(9) In addition autoradiography was performed to localize labelled cells in the inner ear.
(10) Handing Greater Manchester’s £6bn health and social care budget over to the city’s combined authority is the most exciting experiment in local government and the health service in decades – but the risks are huge.
(11) Community owned and run local businesses are becoming increasingly common.
(12) This effect was more marked in breast cancer patients which may explain our earlier finding that women with upper body fat localization are at increased risk for developing breast cancer.
(13) This study was designed to investigate the localization and cyclic regulation of the mRNA for these two IGFBPs in the porcine ovary, RNA was extracted from whole ovaries morphologically classified as immature, preovulatory, and luteal.
(14) These findings suggest that clonidine transdermal disks lower blood pressure in hypertensive patients, but produce local skin lesions and general side effects.
(15) Angiopathic and traumatic influences conditioned by metabolism, apart from local peculiarities are taken into consideration.
(16) Immunofluorescence analysis of Pr-28 antigen showed that the antigen was localized mainly in perinuclear cytoplasm.
(17) The authors report 4 new cases of heterotopic pancreas in children with prepyloric, jejunal, Meckel's diverticulum and mesenteric localization.
(18) The Nazi extermination of Jews in Lithuania (aided enthusiastically by local Lithuanians) was virtually total.
(19) Results in May 89 emphasizes: the relevance and urgency of the prevention of AIDS in secondary schools; the importance of the institutional aspect for the continuity of the project; the involvement of the pupils and the trainers for the processus; the feasibility of an intervention using only local resources.
(20) The amino-terminal region of a 70 kDa mitochondrial outer membrane protein of yeast and the presequence of cytochrome c1, an inner membrane protein exposed to the intermembrane space, are thought to be responsible for localizing the proteins in their final destinations after synthesis in the cytosol.
Locus
Definition:
(n.) A place; a locality.
(n.) The line traced by a point which varies its position according to some determinate law; the surface described by a point or line that moves according to a given law.
Example Sentences:
(1) The fine structure of neurofibrillary tangles in the hippocampal gyrus, substantia nigra, pontine nuclei and locus coeruleus of the brain was postmortem studied in a case of progressive supranuclear palsy.
(2) Large gender differences were found in the correlations between the RAS, CR, run frequency, and run duration with the personality, mood, and locus of control scores.
(3) It is concluded that in the mouse model the ability of buspirone to reduce the aversive response to a brightly illuminated area may reflect an anxiolytic action, that the dorsal raphe nucleus may be an important locus of action, and that the effects of buspirone may reflect an interaction at 5-hydroxytryptamine receptors.
(4) The Notch locus in Drosophila encodes a transmembrane protein required for the determination of cell fate in ectodermal cells.
(5) The second protein could represent either an allozymic form of the enzyme or the product of a distinct locus.
(6) The availability of locus-specific probes should significantly expand the role of minisatellite markers in population biology.
(7) The effects of clozapine on the spontaneous firing rate of noradrenergic (NE, locus coeruleus), dopaminergic (DA, zona compacta, ventral tegmental area) and non-dopaminergic (zona reticulata) neurons was studied in chloral hydrate anesthetized rats.
(8) Twenty-nine deletion breakpoints were mapped in 220 kb of the DXS164 locus relative to potential exons of the Duchenne and Becker muscular dystrophy gene.
(9) Mice homozygous for mutations at either locus exhibit several phenotypic abnormalities including a virtual absence of mast cells.
(10) These data suggest that increased TNF production may be responsible for endotoxin hypersensitivity in TCDD-treated mice and that the Ah locus mediates this response.
(11) (3) Two RFLP defined patterns of the DQA1 locus, DQA1.5 (DQA1*0501) and DQA1.8 (DQA1*0401, *0601) are strongly associated with the disease.
(12) Interspecific hybridization between sexual species carrying different b-alleles and producing different B subunits may be responsible for the heterozygosity at the lactate dehydrogenase b-locus in diploid parthenogenetic Cnemidophours.
(13) These findings are consistent with reports that implicate the PYK locus in yeast cell cycle control and suggest that it may be challenging to model relations between fitness and activity for multifunctional proteins.
(14) Evidence for a third locus, ENO3, is supplied by the electrophoretic pattern of muscle extracts.
(15) The data indicate that the locus for the alpha chain of the T-cell receptor is split by the chromosomal breakpoint between the V alpha and the C alpha gene segments, and that the V alpha segments are proximal to the C alpha segment within chromosome band 14q11.2.
(16) The new scale appears to be a more sensitive measure of locus of control than Rotter's scale.
(17) Incomplete penetrance of the simpler pattern suggests that this genetic locus interacts in a probabilistic manner with epigenetic mechanisms involved in morphogenesis of the cerebellum.
(18) Proposed models for the inheritance of locus-specific methylation phenotypes in somatic cells include those in which there is stable inheritance of a methylation pattern such that all cells contain a similarly methylated locus, as well as models in which the inheritance of methylation can be variable.
(19) Extensive LSR data were obtained as a by-product of specific-locus experiments.
(20) The deficits noted in the granule cells of the dentate gyrus in this study were more severe than those found in our previous studies on the effect of the low protein diet in these same rats on visual cortical pyramidal cells and on the 3 cell types in the nucleus raphe dorsalis and nucleus locus coeruleus.