(superl.) Not precise or exact; vague; indeterminate; as, a loose style, or way of reasoning.
(superl.) Unbound; untied; unsewed; not attached, fastened, fixed, or confined; as, the loose sheets of a book.
(superl.) Free from constraint or obligation; not bound by duty, habit, etc. ; -- with from or of.
(superl.) Not tight or close; as, a loose garment.
(superl.) Not dense, close, compact, or crowded; as, a cloth of loose texture.
(superl.) Not strict in matters of morality; not rigid according to some standard of right.
(superl.) Unconnected; rambling.
(superl.) Lax; not costive; having lax bowels.
(superl.) Dissolute; unchaste; as, a loose man or woman.
(superl.) Containing or consisting of obscene or unchaste language; as, a loose epistle.
(n.) Freedom from restraint.
(n.) A letting go; discharge.
(a.) To untie or unbind; to free from any fastening; to remove the shackles or fastenings of; to set free; to relieve.
(a.) To release from anything obligatory or burdensome; to disengage; hence, to absolve; to remit.
(a.) To relax; to loosen; to make less strict.
(a.) To solve; to interpret.
(v. i.) To set sail.
Example Sentences:
(1) Factors associated with higher incidence of rejection included loose sutures, traumatic wound dehiscence, and grafts larger than 8.5 mm.
(2) He is a leader and helps manage the defence, while Pablo Armero can be a bit of a loose cannon but he is certainly a talented player.
(3) This study investigates the use of the incentive inspirometer to observe the effects of tight versus loose clothing on inhalation volume with 17 volunteer subjects.
(4) Security forces have also tried to wrest back the Sunni stronghold of Tikrit from a loose alliance of Isis fighters, other jihadist groups and former Saddam Hussein loyalists.
(5) His shot, though, was pawed on to the inside of the post by David Marshall and it was left to Victor Wanyama to lash the loose ball into the empty net.
(6) We had our bicycles and we were just turned loose all day.
(7) Our model is a development of previous models, but differs in several respects: the overall activity is assumed to be dependent on the error level, the effect of errors in the translating system, giving rise to additional errors in the succeeding generation of products, is explicitly included as a special term in our model, and scavenging enzymes are assumed to break down and eliminate products with a loose structure.
(8) Clearance into the mediastinum may be the major pathway for liquid sequestered in the loose, binding connective tissue.
(9) Two tibial components (2%) were believed to be mechanically loose, but no revisions for mechanical loosening were done.
(10) The results indicate that the optimal cruciform loop size is four bases, with loose 'breathing' at the first base pair at the top of the cruciform stem at 37 degrees C, and little or no opening of base pairs at the four-way junction.
(11) Theresa May’s plan for a loose alliance with the Democratic Unionists to prop up her government was thrown into confusion on Saturday night after the Northern Ireland party contradicted a No 10 announcement that a deal had been reached.
(12) We have also confirmed loose linkage with the marker (Mfd22, locus D4S171) used to establish the initial assignment of the disorder to chromosome 4.
(13) As demonstrated by Ficoll density gradient centrifugation and HPLC gel filtration, the cholate dialysis method made the reductase bind tightly to the liposomal membranes, while the incubation with the preformed vesicles made the reductase bind loosely to the membranes.
(14) In its more loose, common usage, it's a game in which the rivalry has come to acquire the mad, rancorous intensity of a Celtic-Rangers, a Real Madrid-Barcelona, an Arsenal-Tottenham, a River Plate-Boca Juniors.
(15) Twenty-one of 24 adult male and female cattle egrets (Bubulcus ibis ibis) collected in Geneva County, Alabama had numerous white cyst-like structures (1,466 microns X 354 microns) found within the loose connective tissues of the skeletal muscles of the inguinal region, beneath the serosa of the proventriculus and in the heart beneath the epicardium (one adult male bird).
(16) SCLC variant lines could further be divided into (a) biochemical variant lines having variant biochemical profile but retaining typical SCLC morphology and growth characteristics; and (b) morphological variant (SCLC-MV) lines having variant biochemical profile, altered morphology (features of large cell undifferentiated carcinoma) and altered growth characteristics (growth as loosely attached floating aggregates, relatively short doubling times and cloning efficiencies).
(17) At rostral levels, one third of the tracts are loosely built forming a king of curtain, while they become more compact at caudal levels.
(18) (1) The prerequisite for development of cholesteatoma is a cholesteatoma bed, that is a loose subepithelial connective tissue layer which acts as a nutrient bed and makes papillary growth of squamous epithelium possible.
(19) His mother is Denise Welch, late of Corrie and Loose Women, and his father his Tim Healy, who was briefly famous 30 years ago for his role in Auf Wiedersehen, Pet.
(20) Initially, 4-5 days post-operative, the plasma clot maintained the grafted cells in a loose sponge-like sack at the site of implantation.
Tightly
Definition:
(adv.) In a tight manner; closely; nearly.
Example Sentences:
(1) Freshly isolated sarcoplasmic reticulum vesicles contain 0.05 mol of tightly bound ADP and 0.03 mol of tightly bound ATP per mol of Ca2+, Mg2+-ATPase (ATP phosphohydrolase, EC 3.6.1.3).
(2) The expression of the Pgp isoforms appears to be tightly regulated and, at least in some cells, under complex hormonal control.
(3) Whereas the tight junctions of endoneurial capillaries are known to prevent certain blood-borne substances from entering the endoneurium, it was not clear whether the permeability of the pulpal capillaries, which are distant from the nerve fibres, could affect the nerve fibre environment.
(4) The cells are predominantly monopolar, tightly packed, and are flattened at the outer border of the ring.
(5) These data indicate that topoisomerase I and RNA polymerase I are tightly complexed both in vivo and in vitro, and suggest a role for DNA topoisomerase I in the transcription of ribosomal genes.
(6) Immunofluorescence and immunoelectronmicroscopy experiments demonstrated that while tight junctions demarcate PAS-O distribution in confluent cultures, apical polarity could be established at low culture densities when cells could not form tight junctions with neighboring cells.
(7) Investigations have been made to determine the identity and binding characteristics of the pterins that are bound tightly to dihydrofolate reductases which are isolated from vertebrate sources by a well established procedure.
(8) At all times, a tight inverse correlation exists between ATP and IMP concentrations.
(9) Recently, a gene for ITD (DYT1) in a non-Jewish kindred was located on chromosome 9q32-34, with tight linkage to the gene encoding gelsolin (GSN).
(10) This study investigates the use of the incentive inspirometer to observe the effects of tight versus loose clothing on inhalation volume with 17 volunteer subjects.
(11) In contrast, interchange of the histones and tightly bound non-histone protein DNA complexes from hormone-withdrawn and estrogen-stimulated chromatins during reconstitution did not affect the level of mRNAOV sequences produced.
(12) Using microelectrodes and various microscopic techniques active Na+ absorption as well as K+ secretion has been localized to the principal cells, while Cl- absorption was found to proceed largely, though not exclusively, through the tight junctions between cells.
(13) The successful establishment of a postcrisis SV-40 T antigen transformed epithelial cell line, 1HAEo-, which retains tight junctions and vectorial ion transport, is described.
(14) The present investigation shows that the intramembranous proteins of tight and gap junctions are mobile structures within the fluid membrane.
(15) In contrast, after incubation with 0.5% DOC, the core microfilaments are no longer tightly bundled yet the lateral arms remain attached with a distinct 33-nm periodicity.
(16) The data collected by several approaches reveal that assembly and maturation of vaccinia involves a tightly coupled sequence of interrelated events including the assembly of the envelope, post-translational cleavage of several virion polypeptides, and induction of the core enzymes.
(17) The tight coupling between neuronal activity and oxidative energy metabolism forms the basis for the use of cytochrome oxidase as an endogenous metabolic marker for neurons.
(18) When using a nylon thread for the attachment of a pseudophakos to the iris, it may happen that the suture is slung tightly around the implant-lens.
(19) Some antibodies and other proteins bind tightly to nitrocellulose and dissociation of these proteins by Tween 20 is barely detectable.
(20) Independent experts warn that rumours and deliberate misinformation about the regime are rife, partly because it is impossible to verify or disprove most stories about the tightly controlled country's elite.