(superl.) Not precise or exact; vague; indeterminate; as, a loose style, or way of reasoning.
(superl.) Unbound; untied; unsewed; not attached, fastened, fixed, or confined; as, the loose sheets of a book.
(superl.) Free from constraint or obligation; not bound by duty, habit, etc. ; -- with from or of.
(superl.) Not tight or close; as, a loose garment.
(superl.) Not dense, close, compact, or crowded; as, a cloth of loose texture.
(superl.) Not strict in matters of morality; not rigid according to some standard of right.
(superl.) Unconnected; rambling.
(superl.) Lax; not costive; having lax bowels.
(superl.) Dissolute; unchaste; as, a loose man or woman.
(superl.) Containing or consisting of obscene or unchaste language; as, a loose epistle.
(n.) Freedom from restraint.
(n.) A letting go; discharge.
(a.) To untie or unbind; to free from any fastening; to remove the shackles or fastenings of; to set free; to relieve.
(a.) To release from anything obligatory or burdensome; to disengage; hence, to absolve; to remit.
(a.) To relax; to loosen; to make less strict.
(a.) To solve; to interpret.
(v. i.) To set sail.
Example Sentences:
(1) Factors associated with higher incidence of rejection included loose sutures, traumatic wound dehiscence, and grafts larger than 8.5 mm.
(2) He is a leader and helps manage the defence, while Pablo Armero can be a bit of a loose cannon but he is certainly a talented player.
(3) This study investigates the use of the incentive inspirometer to observe the effects of tight versus loose clothing on inhalation volume with 17 volunteer subjects.
(4) Security forces have also tried to wrest back the Sunni stronghold of Tikrit from a loose alliance of Isis fighters, other jihadist groups and former Saddam Hussein loyalists.
(5) His shot, though, was pawed on to the inside of the post by David Marshall and it was left to Victor Wanyama to lash the loose ball into the empty net.
(6) We had our bicycles and we were just turned loose all day.
(7) Our model is a development of previous models, but differs in several respects: the overall activity is assumed to be dependent on the error level, the effect of errors in the translating system, giving rise to additional errors in the succeeding generation of products, is explicitly included as a special term in our model, and scavenging enzymes are assumed to break down and eliminate products with a loose structure.
(8) Clearance into the mediastinum may be the major pathway for liquid sequestered in the loose, binding connective tissue.
(9) Two tibial components (2%) were believed to be mechanically loose, but no revisions for mechanical loosening were done.
(10) The results indicate that the optimal cruciform loop size is four bases, with loose 'breathing' at the first base pair at the top of the cruciform stem at 37 degrees C, and little or no opening of base pairs at the four-way junction.
(11) Theresa May’s plan for a loose alliance with the Democratic Unionists to prop up her government was thrown into confusion on Saturday night after the Northern Ireland party contradicted a No 10 announcement that a deal had been reached.
(12) We have also confirmed loose linkage with the marker (Mfd22, locus D4S171) used to establish the initial assignment of the disorder to chromosome 4.
(13) As demonstrated by Ficoll density gradient centrifugation and HPLC gel filtration, the cholate dialysis method made the reductase bind tightly to the liposomal membranes, while the incubation with the preformed vesicles made the reductase bind loosely to the membranes.
(14) In its more loose, common usage, it's a game in which the rivalry has come to acquire the mad, rancorous intensity of a Celtic-Rangers, a Real Madrid-Barcelona, an Arsenal-Tottenham, a River Plate-Boca Juniors.
(15) Twenty-one of 24 adult male and female cattle egrets (Bubulcus ibis ibis) collected in Geneva County, Alabama had numerous white cyst-like structures (1,466 microns X 354 microns) found within the loose connective tissues of the skeletal muscles of the inguinal region, beneath the serosa of the proventriculus and in the heart beneath the epicardium (one adult male bird).
(16) SCLC variant lines could further be divided into (a) biochemical variant lines having variant biochemical profile but retaining typical SCLC morphology and growth characteristics; and (b) morphological variant (SCLC-MV) lines having variant biochemical profile, altered morphology (features of large cell undifferentiated carcinoma) and altered growth characteristics (growth as loosely attached floating aggregates, relatively short doubling times and cloning efficiencies).
(17) At rostral levels, one third of the tracts are loosely built forming a king of curtain, while they become more compact at caudal levels.
(18) (1) The prerequisite for development of cholesteatoma is a cholesteatoma bed, that is a loose subepithelial connective tissue layer which acts as a nutrient bed and makes papillary growth of squamous epithelium possible.
(19) His mother is Denise Welch, late of Corrie and Loose Women, and his father his Tim Healy, who was briefly famous 30 years ago for his role in Auf Wiedersehen, Pet.
(20) Initially, 4-5 days post-operative, the plasma clot maintained the grafted cells in a loose sponge-like sack at the site of implantation.
Unwind
Definition:
(v. t.) To wind off; to loose or separate, as what or convolved; to untwist; to untwine; as, to unwind thread; to unwind a ball of yarn.
(v. t.) To disentangle.
(v. i.) To be or become unwound; to be capable of being unwound or untwisted.
Example Sentences:
(1) Unlike cisplatin, bis(platinum) complex binding does not unwind supercoiled DNA.
(2) Of the 47 compounds that were positive or equivocal in the alkaline unwinding assay, only carbon tetrachloride and prednisolone were negative in the mouse lymphoma assay, while 12 of the 19 compounds that were negative in the alkaline unwinding assay were positive in the mouse lymphoma assay.
(3) As suggested from the high level of sequence similarity of these viral proteins with the recently described superfamilies of helicase-like proteins (3-5), the NTBM-containing cylindrical inclusion (CI) protein from plum pox virus (PPV), which belongs to the potyvirus group of positive strand RNA viruses, is shown to be able to unwind RNA duplexes.
(4) This limited unwinding of heterologous duplex DNA, termed heterologous unwinding, was detected within 30 seconds and reached a steady state within a few minutes.
(5) Comparison of the superhelix densities obtained by both methods permits a calculation of an unwinding angle for ethidium.
(6) The exposure of the cells from mussel haemolymph and from mouse L1210 to a genotoxic compound such as dimethylsulfate results in DNA damage and consequently in a reduction of the unwinding time.
(7) As for unwinding, the rituals of it give a satisfying end to the shape of my day.
(8) Chromosome replication appears to initiate in E. coli when the dnaA boxes in oriC become filled with DnaA protein, which could simultaneously mediate both the unwinding of the origin for the start of polymerization and the attachment of oriC to the cell envelope (Bramhill and Kornberg, 1988; Løbner-Olesen et al., 1989; Pierucci et al., 1989).
(9) The protein fraction containing the 93 000 dalton protein had considerable unwinding activity, depressing the melting temperature of poly(dA-dT) by 39 degrees C. The protein fraction containing the bulk of the 35 000 dalton protein did not have unwinding activity.
(10) The required cellular protein may be a eukaryotic single-stranded-DNA-binding protein (SSB), since unwinding of the template is also observed when Escherichia coli SSB is substituted for the HeLa protein fraction.
(11) Evidence is presented that the first step in initiation of SV40 DNA replication involves the specific binding of T antigen to the origin, followed by the local unwinding of the two strands of the template.
(12) Complex formation leads to very little, if any, unwinding of the duplex.
(13) It is suggested that the gene D product may function in replicative form DNA unwinding to expose the template for transcription.
(14) Topotecan (SK&F 104864) is a novel antitumor agent whose mechanism of action is inhibition of the DNA unwinding protein topoisomerase I.
(15) We used an RNA unwinding assay to compare the activities of these factors from the different species.
(16) The extension and unwinding of the DNA helix brought about by the intercalating chromophore of the dye molecules are not requirements for the entrapment process.
(17) Second, mutant T antigens with impaired ATPase function also showed a reduced DNA unwinding activity.
(18) Analysts at UBS said: “After Friday’s ... market plunge, many turned to the authorities for support measures as concerns rose that the rapid unwinding of margin trades was fuelling the sell-off.
(19) It is proposed that the DNA-unwinding activity causes the efficient recombination, DNA repair, and SOS induction (after application of nalidixic acid) in recD mutants.
(20) But within minutes of the five-year-old video of Obama being released by the Daily Caller website on Tuesday night , the "exclusive" began to unwind amid criticism that much of it had been reported at the time and the content was anything but explosive.