(n.) One that lurches or lies in wait; one who watches to pilfer, or to betray or entrap; a poacher.
(n.) One of a mongrel breed of dogs said to have been a cross between the sheep dog, greyhound, and spaniel. It hunts game silently, by scent, and is often used by poachers.
(n.) A glutton; a gormandizer.
Example Sentences:
(1) These results indicate that in spite of cerebellar degeneration and ataxia, lurcher mutants are not impaired in all tests measuring motor function.
(2) Immunocytochemical analysis of aggregation chimeras made using either of the mutants, Lurcher or Purkinje cell degeneration, previously showed that only Bergmann glia close to surviving Purkinje cells expressed an apparently normal level of the enzyme, glycerol-3-phosphate dehydrogenase (GPDH) (Fisher and Mullen, 1988).
(3) Lurcher Purkinje cells, in contrast, receive scattered contacts by GAD-IR puncta and possess a "cap" of such elements surrounding the primary dendrite and apical soma.
(4) Lurcher mice show 100% degeneration of Purkinje cells, starting during the second postnatal week, while staggerer mice show reduced numbers of Purkinje cells in a distinctive mediolateral distribution from the time of birth, with the remainder grossly stunted.
(5) We conclude that the Lurcher cerebellum is particularly sensitive to thyroid hormone, and that it responds to low levels of hyperthyroidism in a distinct way.
(6) It was found that, in comparison to littermate controls, the lurcher mutants alternated less often in a discrete two-trial procedure of spontaneous alternation and did not habituate to maze stimuli in a T-maze.
(7) The response of IP neurones in normal and Lurcher mice appear to be similar to those observed in the normal and experimentally cerebellar decorticate cat, respectively.
(8) These afferents maintain dense perisomatic nests around Purkinje cells, even in P13-15 lurchers.
(9) In the present study, we examined the IL-6 mRNA expression by stimulated peripheral macrophages of two cerebellar mutant mice, the staggerer and the lurcher mutants.
(10) It is concluded that the mossy fibre input to the cerebellum is intact in the Lurcher mutant mouse.
(11) In contrast, the lurcher cerebellum exhibited enzyme activity in both molecular and granular layers.
(12) This study examines the question of whether intrinsically defective mutant Lurcher Purkinje cells, which degenerate during postnatal weeks two to five, followed by later loss of granule cells are competent to respond to neonatal hyperthyroidism, which is known to cause premature differentiation of Purkinje cells and an acceleration of the peak of proliferation in granule cells in normal rodent cerebellum.
(13) Although they are normal in number, previous work from our laboratories has shown that when the genetically wild-type Purkinje cells are present in the mosaic environment of the lurcher chimeric mouse they develop a very unusual morphology.
(14) The response characteristics of interpositus neurones (IP) to sciatic nerve stimulation were studied in normal and Lurcher mutant mice under pentobarbitone anaesthesia.
(15) This proved incorrect and, indeed, the Purkinje cells in the lurcher chimeras show changes of a predominantly atrophic nature.
(16) Quantitative analysis of Golgi-Cox impregnated material reveals that in lurcher chimeras the Purkinje cell dendritic arbor is reduced by more than 60% compared to wild-type animals.
(17) In lurcher mice, Purkinje cells degenerate during the first few postnatal weeks, after receiving synaptic contacts from both inferior olivary neurons and granule cells.
(18) Lurcher is an autosomal dominant mutation in the mouse.
(19) Cerebella of Lurcher and control age-matched (from P8 to P16) mice were analysed by calbindin immunostaining, silver impregnation and quantitative electron microscopy.
(20) These benzodiazepine binding sites in washed homogenates or tissue sections displayed a gamma-aminobutyrate-induced enhancement of [3H]flunitrazepam binding which occurred to the same extent in both Lurcher and normal cerebellum, a facilitatory effect which could be blocked by the addition of bicuculline methobromide.