(n.) The working parts of a machine, engine, or instrument; as, the machinery of a watch.
(n.) The supernatural means by which the action of a poetic or fictitious work is carried on and brought to a catastrophe; in an extended sense, the contrivances by which the crises and conclusion of a fictitious narrative, in prose or verse, are effected.
(n.) The means and appliances by which anything is kept in action or a desired result is obtained; a complex system of parts adapted to a purpose.
Example Sentences:
(1) It is argued that this process drove the evolution of present 5' and 3' splice sites from a subset of proto-splice sites and also drove the evolution of a more efficient splicing machinery.
(2) The data suggest that proinsulin, normally processed in secretory granules and released via the regulated pathway, may also be processed, albeit less efficiently, by the constitutive pathway conversion machinery.
(3) These observations suggest that pertubation of surface immunoglobulin molecules on CH31 immature B cells causes down-regulation of their antigen-processing machinery.
(4) We provide direct experimental evidence supporting the facts that these additional mechanistic components do exist and that the liver glutamate dehydrogenase reaction is indeed driven by just such machinery.
(5) These surplus chromophores become esterified and are temporarily taken up by the pigment epithelium to be re-entered into the visual cycle as fast as they can be processed by the regenerative machinery of the rod outer segments.
(6) Its diplomatic machinery is a little bit rusty," said Zhu Feng, of Peking University's centre for international and strategic studies.
(7) But, as extended survival at 43 degrees Celsius depends absolutely on the ability of cells to continually synthesize HSPs, it appears that a prior heat shock as well as the recovery from protein synthesis inhibition elicits a change in the protein synthetic machinery which allows the translation of HSP mRNAs at what would otherwise be a nonpermissive temperature for protein synthesis.
(8) Furthermore, the evidence that anti-CD3 antibodies increase the efficacy of the cytotoxic machinery might support the use of these molecules in designing new immunotherapeutic approaches against tumor targets.
(9) The mnn9 mutation also increases the transit time for invertase secretion, meaning that this mutation could affect the processing machinery in the Golgi apparatus.
(10) This technology allows the use of RNA virus replication machinery to express heterologous sequences.
(11) Geometrical comparison of this model with an experimentally determined structure for chicken DHFR suggests that chromosomal and type II R-plasmid specified enzymes may have independently evolved similar catalytic machinery for substrate reduction.
(12) To investigate whether TGF-beta also influences the glycosaminoglycan (GAG) chain-synthesizing machinery, we also characterized GAGs derived from proteoglycans synthesized by TGF-beta-treated cells.
(13) The effects of dantrolene on the sarcoplasmic reticulum and contractile machinery were examined in skinned skeletal muscles of guinea pigs.
(14) Secretion, however, depends on neither an N-terminal signal sequence nor on SecA, which is part of the normal cellular export machinery for periplasmic and outer membrane proteins.
(15) The localization of these key components of the pre-mRNA splicing machinery to speckled nuclear regions suggests that these regions may be involved in pre-mRNA splicing.
(16) In circumstances in which energy conversion rate and supplies of reducing power exceed the capacity of the biosynthetic machinery, energy-dependent H2 production presumably represents a regulatory device that facilitates "energy-idling."
(17) Overexpression of these genes, which probably encode lipoproteins, could have deleterious effects on E. coli hosts, possibly as a result of impairing the protein export machinery.
(18) Major intra-abdominal arteriovenous fistulas usually present with a machinery bruit over a pulsatile mass, but may present more subtly with pain and otherwise unexplained hematuria.
(19) Sales of tractors and other farm machinery are down by 70%, said Dave Dorsett of Reynolds farm equipment in Martinville.
(20) By using a temperature-sensitive allele, we have found that that norpA mutation has little or no effect on either the rhodopsin-metarhodopsin transition or the machinery of quantum bump production.
Pivot
Definition:
(n.) A fixed pin or short axis, on the end of which a wheel or other body turns.
(n.) The end of a shaft or arbor which rests and turns in a support; as, the pivot of an arbor in a watch.
(n.) Hence, figuratively: A turning point or condition; that on which important results depend; as, the pivot of an enterprise.
(n.) The officer or soldier who simply turns in his place whike the company or line moves around him in wheeling; -- called also pivot man.
(v. t.) To place on a pivot.
Example Sentences:
(1) Excessive accumulation of hydrogen ions in the brain may play a pivotal role in initiating the necrosis seen in infarction and following hyperglycemic augmentation of ischemic brain damage.
(2) The function of motherese has become a pivotal issue in the language-learning literature.
(3) Glucose is the principal source for energy production in the brain, and undisturbed glucose metabolism is pivotally significant for normal function of this organ.
(4) Currently employed clinical indicators of perfusion provide inadequate warning of developing hazards caused by marginal perfusion in certain vital organs or "peripheral" tissues that are pivotal to postsurgical wound healing.
(5) Endobronchial biopsy and bronchial lavage studies following inhaled PAF did not show any increase in the number of activation of eosinophils, which are pivotal in the pathogenesis of BHR.
(6) Turkish police have stormed the offices of an opposition media group days before the country’s pivotal election, in a crackdown on companies linked to a US-based cleric and critic of President Recep Tayyip Erdoğan .
(7) It was the introduction of Aluko that proved pivotal.
(8) This article discusses the effect of existing statutes and case law on three pivotal questions: To what sort of information are people entitled?
(9) It has been generally accepted that the deregulation of oncogenes or their regulators play a pivotal role in progression of this prevalent disease.
(10) The fact that Fraser suggested Pinter write one of the pivotal scenes, in which Emma challenges Jerry to leave his wife, was a revelation, he says.
(11) Marine Rotational Force – Darwin” (MRF-D) is one of four American marine air ground task forces (MAGTFs) in the Asia-Pacific region, along with those in Guam, Hawaii and Okinawa, the sum of which make up a central strategic pillar of the pivot.
(12) Facebook Twitter Pinterest ‘I’m president, they’re not’: Donald Trump at rally in Washington Trump is “much more resilient” than his opponents allow, said Newt Gingrich, the former House speaker, before pivoting to a plug for his new book, Understanding Trump .
(13) Twitter has become pivotal in organising anti-government dissent in the past year: the Occupy Gezi movement, which marches against the recently passed internet censorship bill that allows the government to block any content within four hours without a court order, and the massive street protest and the funeral attended by hundreds of thousands after the death of 15-year-old Berkin Elvan , were initiated via social media.
(14) Verbal and non verbal communication skills (with the patient and the team) are pivotal in this approach; relatives are considered partners in the care of the patient and an essential element of the caring environment.
(15) This year will mark the start of a pivotal chapter for development as the UN finalises ambitious goals this autumn to improve all lives and secure a healthy planet.
(16) The 5' cap structure of eucaryotic mRNA plays a pivotal role in mRNA metabolism.
(17) Thirty years after one of the pivotal clashes in the miners' strike of 1984 when violent confrontations erupted at the Orgreave coking plant, the area outside Sheffield could barely look more different.
(18) Arthritic symptoms were present at operation in thirty patients, while thirty-four had no postoperative objective signs of pivot shift or instability.
(19) Two lines of evidence indicate that the general transcription factor TFIIB is a pivotal component in the mechanism by which an acidic activator functions.
(20) If cortical actin filaments are disrupted with dihydrocytochalasin B, processes form that are similar to those induced by dBcAMP suggesting that the disruption of the cortical actin network is the pivotal step in process formation.