(n.) The name of a female fairy, esp. the queen of the fairies; and hence, sometimes, any fairy.
() p. p. of Made.
(superl.) Disordered in intellect; crazy; insane.
(superl.) Excited beyond self-control or the restraint of reason; inflamed by violent or uncontrollable desire, passion, or appetite; as, to be mad with terror, lust, or hatred; mad against political reform.
(superl.) Proceeding from, or indicating, madness; expressing distraction; prompted by infatuation, fury, or extreme rashness.
(superl.) Extravagant; immoderate.
(superl.) Furious with rage, terror, or disease; -- said of the lower animals; as, a mad bull; esp., having hydrophobia; rabid; as, a mad dog.
(superl.) Angry; out of patience; vexed; as, to get mad at a person.
(superl.) Having impaired polarity; -- applied to a compass needle.
(v. t.) To make mad or furious; to madden.
(v. i.) To be mad; to go mad; to rave. See Madding.
(n.) An earthworm.
Example Sentences:
(1) Do [MPs] remember the madness of those advertisements that talked of the cool fresh mountain air of menthol cigarettes?
(2) Right from the beginning, I had been mad about movies.
(3) "This will be not only be a postcode lottery, but a States vs Europe lottery and that would be madness."
(4) It took years of prep work to make this sort of Übermensch thing socially acceptable, let alone hot – lots of “legalize it!” and “you are economic supermen!” appeals to the balled-and-entitled toddler-fists of the sociopathic libertechian madding crowd to really get mechanized mass-death neo-fascism taken mainstream .
(5) Or perhaps the "mad cow"-fuelled beef war in the late 1990s, when France maintained its ban on British beef for three long years after the rest of the EU had lifted it, prompting the Sun to publish a special edition in French portraying then president Jacques Chirac as a worm.
(6) • +33 2 98 50 10 12, hotel-les-sables-blancs.com , doubles from €105 room only Hôtel Ty Mad, Douarnenez Hôtel Ty Mad In the 1920s the little beach and fishing village of Douarnenez was a favourite haunt of the likes of Pablo Picasso and writer and artist Max Jacob.
(7) If you’re against the RFS, you’re going to make Iowans mad, you’re going to [have] some Iowans question you but the beauty of Iowa is you can take your case to the people,” said Kaufmann.
(8) In its more loose, common usage, it's a game in which the rivalry has come to acquire the mad, rancorous intensity of a Celtic-Rangers, a Real Madrid-Barcelona, an Arsenal-Tottenham, a River Plate-Boca Juniors.
(9) Yes, we can assign more or less responsibility – I blame Austria-Hungary and Germany for their mad determination to destroy Serbia knowing that a general war might result – but there is still plenty of room for disagreement.
(10) It’s good to hear a full-throated defence of social security as a basic principle of civilisation, and a reiteration of the madness of renewing Trident; pleasing too to behold how much Burnham and Cooper have had to belatedly frame their arguments in terms of fundamental principle.
(11) The blue skipping rope – that’s the key to this race.” My eight-year-old daughter looked at me like I was mad … but when it came time for the year 3 skipping race, she did as she was told – and duly chalked up a glorious personal best in third place.
(12) The policies of zero tolerance equip local and federal law-enforcement with increasingly autocratic powers of coercion and surveillance (the right to invade anybody's privacy, bend the rules of evidence, search barns, stop motorists, inspect bank records, tap phones) and spread the stain of moral pestilence to ever larger numbers of people assumed to be infected with reefer madness – anarchists and cheap Chinese labour at the turn of the 20th century, known homosexuals and suspected communists in the 1920s, hippies and anti-Vietnam war protesters in the 1960s, nowadays young black men sentenced to long-term imprisonment for possession of a few grams of short-term disembodiment.
(13) Maleic acid dimethylester (MAD) was investigated in acute and subacute dermal toxicity studies, for sensitization potential, and for in vivo and in vitro genotoxicity.
(14) Or maybe it's the other way round - the constant touring is a manifestation of their madness.
(15) And while one may think that the bishops of the Church of England don’t quite have the sex appeal of Russell Brand, we think that we should counter it.” While the bishops stress that their letter is not intended as “a shopping list of policies we would like to see”, they do advocate a number of specific steps, including a re-examination of the need for Trident, a retention of the commitment to funding overseas aid and a reassessment of areas where regulations fuel “the common perception of ‘health and safety gone mad’”.
(16) He still thinks Labour was mad to get him of all people to work inside the system.
(17) That has changed over the past few years as wallpaper has made a comeback and women have remembered that they like wearing madly patterned dresses – particularly leopard-print ones, or ones with huge flowers.
(18) Seeing the performance later in Edinburgh, I was impressed by Briers' ability to encompass the hero's rage and madness.
(19) It would be hard to allow working from home if I thought that they were all watching box sets of Mad Men.
(20) People thought she'd gone mad, but in retrospect it's clear that this was precisely what she needed in order to move forward.
Nad
Definition:
() Alt. of Nadde
Example Sentences:
(1) One hour after direct mechanical cardiomassage (DMCM) a moderately pronounced edema of the intercellular spaces in the basal compartment of the seminiferous epithelium, normal content of lactate and succinate dehydrogenases, and a certain decrease in the activity of glucose-6-phosphate dehydrogenases and NAD- and NADP-diaphorases were noted.
(2) Transformed mammalian cells express both the usual NADP-dependent trifunctional methylenetetrahydrofolate dehydrogenase-cyclohydrolase-synthetase as well as the bifunctional NAD-dependent methylenetetrahydrofolate dehydrogenase-cyclohydrolase.
(3) The results are discussed in terms of a two-site model in which separate, but interacting, regions exist on the enzyme to accommodate the adenosine and nicotinamide moieties of NAD, and a single-site model in which the adenosine part of the molecule is bound preferentially and this interacts with the nicotinamide fraction.
(4) The NAD-dependent enzymes (except alpha-GPDH) showed a stronger reactivity in the proximal tubules, while the NADP-dependent ones were more reactive in the thick limb of Henle's loop and distal convoluted tubules.
(5) In contrast, AMP and adenosine did not alter NAD glycohydrolase activity or affect subunit structure.
(6) With cortisol and cortisol-21-aldehyde, product inhibition patterns showed only slope effects with steroid product and NAD+, suggesting a "random" mechanism.
(7) Kinetic studies of glutamate dehydrogenase were made with wide concentration ranges of the coenzymes NAD(+) and NADP(+) and the substrates glutamate and norvaline.
(8) Both substances decreased the concentrations of NAD(+) in the islet cells to about 10% of the control values within 2h after injection.
(9) We investigated the denaturation of tetrameric 20 beta-hydroxysteroid dehydrogenase (20R)-17 beta,20 beta,21-trihydroxysteroid:NAD+ oxidoreductase, EC 1.1.1.53) to find out whether intermediate states are formed during the process.
(10) On subfractionation of this crude mitochondrial fraction with continuous sucrose density gradients, most of the activity of the three enzymes was found at a higher density than NAD+-isocitrate dehydrogenase and at about the same density as glutamate dehydrogenase, confirming earlier reported data for acetyl-CoA synthase.
(11) The effect of dicoumarol on glucuronidation of 3-OH-benzo(a)pyrene (BP) appears to be due to inhibition of UDPglucuronosyltransferase (UDPGT) and not to an inhibited DT-diaphorase (NAD(P)H:quinone oxidoreductase); to date the only enzyme known to be inhibited by dicoumarol.
(12) The increase in concentration of organic cosolvents results in a 2-2.5-fold increase of the maximal reaction rate and a decrease of Michaelis constant for formate of NAD(+)-dependent formate dehydrogenase from methylotrophic bacteria Pseudomonas sp.
(13) Furthermore, NADP was over 1000-fold more potent than NAD in inhibiting the enzyme competitively with respect to NADH.
(14) The possible participation of a Ca(2+)-induced activation of NAD-isocitrate dehydrogenase in this process was investigated.
(15) A 4.1-kb EcoRI fragment which includes the gene (gldA) encoding a glycerol dehydrogenase (G1DH; EC 1.1.1.6; glycerol:NAD oxidoreductase) from Bacillus stearothermophilus var.
(16) It is supposed that the stimulating effect of lactate with NAD+ on the mitochondria respiration is not so much a result of the membrane-damaged action as a result of oxidation of lactate dehydrogenase reaction products: phosphorylative oxidation of pyruvate and nonconjugated oxidation of NADH.
(17) In the presence of glycolate (glyoxylate), and NADH and NAD alone or together in physiological proportions, the rate of serine-to-glycerate conversion was enhanced and sustained by the addition of malate.
(18) Virazole 5'-phosphate was subsequently found to be a potent competitive inhibitor of inosine 5'-phosphate dehydrogenase (IMP:NAD(+) oxidoreductase, EC 1.2.1.14) isolated from Escherichia coli (K(m) = 1.8 x 10(-5) M) with a K(i) of 2.7 x 10(-7) M. Guanosine 5'-phosphate (GMP) was a competitive inhibitor of this enzyme with a K(i) of 7.7 x 10(-5) M. Virazole 5'-phosphate was similarly active against IMP dehydrogenase isolated from Ehrlich ascites tumor cells, with a K(i) of 2.5 x 10(-7) M. The K(m) for this enzyme was 1.8 x 10(-5) M, and the K(i) for GMP was 2.2 x 10(-4) M. These results suggest that the antiviral activity of Virazole might be due to the inhibition of GMP biosynthesis in the infected cell at the step involving the conversion of IMP to xanthosine 5'-phosphate.
(19) The methods described make possible the preparation of fossil samples for light nad transmission electron microscopy.
(20) The activity of soluble NAD-specific hydrogenase was not detected.