(a.) In a mad manner; without reason or understanding; wildly.
Example Sentences:
(1) Do [MPs] remember the madness of those advertisements that talked of the cool fresh mountain air of menthol cigarettes?
(2) Right from the beginning, I had been mad about movies.
(3) "This will be not only be a postcode lottery, but a States vs Europe lottery and that would be madness."
(4) It took years of prep work to make this sort of Übermensch thing socially acceptable, let alone hot – lots of “legalize it!” and “you are economic supermen!” appeals to the balled-and-entitled toddler-fists of the sociopathic libertechian madding crowd to really get mechanized mass-death neo-fascism taken mainstream .
(5) Or perhaps the "mad cow"-fuelled beef war in the late 1990s, when France maintained its ban on British beef for three long years after the rest of the EU had lifted it, prompting the Sun to publish a special edition in French portraying then president Jacques Chirac as a worm.
(6) • +33 2 98 50 10 12, hotel-les-sables-blancs.com , doubles from €105 room only Hôtel Ty Mad, Douarnenez Hôtel Ty Mad In the 1920s the little beach and fishing village of Douarnenez was a favourite haunt of the likes of Pablo Picasso and writer and artist Max Jacob.
(7) If you’re against the RFS, you’re going to make Iowans mad, you’re going to [have] some Iowans question you but the beauty of Iowa is you can take your case to the people,” said Kaufmann.
(8) In its more loose, common usage, it's a game in which the rivalry has come to acquire the mad, rancorous intensity of a Celtic-Rangers, a Real Madrid-Barcelona, an Arsenal-Tottenham, a River Plate-Boca Juniors.
(9) Yes, we can assign more or less responsibility – I blame Austria-Hungary and Germany for their mad determination to destroy Serbia knowing that a general war might result – but there is still plenty of room for disagreement.
(10) It’s good to hear a full-throated defence of social security as a basic principle of civilisation, and a reiteration of the madness of renewing Trident; pleasing too to behold how much Burnham and Cooper have had to belatedly frame their arguments in terms of fundamental principle.
(11) The blue skipping rope – that’s the key to this race.” My eight-year-old daughter looked at me like I was mad … but when it came time for the year 3 skipping race, she did as she was told – and duly chalked up a glorious personal best in third place.
(12) The policies of zero tolerance equip local and federal law-enforcement with increasingly autocratic powers of coercion and surveillance (the right to invade anybody's privacy, bend the rules of evidence, search barns, stop motorists, inspect bank records, tap phones) and spread the stain of moral pestilence to ever larger numbers of people assumed to be infected with reefer madness – anarchists and cheap Chinese labour at the turn of the 20th century, known homosexuals and suspected communists in the 1920s, hippies and anti-Vietnam war protesters in the 1960s, nowadays young black men sentenced to long-term imprisonment for possession of a few grams of short-term disembodiment.
(13) Maleic acid dimethylester (MAD) was investigated in acute and subacute dermal toxicity studies, for sensitization potential, and for in vivo and in vitro genotoxicity.
(14) Or maybe it's the other way round - the constant touring is a manifestation of their madness.
(15) And while one may think that the bishops of the Church of England don’t quite have the sex appeal of Russell Brand, we think that we should counter it.” While the bishops stress that their letter is not intended as “a shopping list of policies we would like to see”, they do advocate a number of specific steps, including a re-examination of the need for Trident, a retention of the commitment to funding overseas aid and a reassessment of areas where regulations fuel “the common perception of ‘health and safety gone mad’”.
(16) He still thinks Labour was mad to get him of all people to work inside the system.
(17) That has changed over the past few years as wallpaper has made a comeback and women have remembered that they like wearing madly patterned dresses – particularly leopard-print ones, or ones with huge flowers.
(18) Seeing the performance later in Edinburgh, I was impressed by Briers' ability to encompass the hero's rage and madness.
(19) It would be hard to allow working from home if I thought that they were all watching box sets of Mad Men.
(20) People thought she'd gone mad, but in retrospect it's clear that this was precisely what she needed in order to move forward.
Manner
Definition:
(n.) Mode of action; way of performing or effecting anything; method; style; form; fashion.
(n.) Characteristic mode of acting, conducting, carrying one's self, or the like; bearing; habitual style.
(n.) The style of writing or thought of an author; characteristic peculiarity of an artist.
(n.) Certain degree or measure; as, it is in a manner done already.
(n.) Sort; kind; style; -- in this application sometimes having the sense of a plural, sorts or kinds.
Example Sentences:
(1) Results suggest that Cd-MT is reabsorbed and broken down by kidney tubule cells in a physiological manner with possible subsequent release of the toxic cadmium ion.
(2) These data indicate that CSF levels are not inversely related to the blood neutrophil count in chronic idiopathic neutropenia and suggest that CSF is not a hormone regulating the blood neutrophil count in a manner analogous to the erythropoietin regulation of circulating erythrocyte levels.
(3) Diazepam inhibited DA release evoked by high concentrations of extracellular K+ in a dose-dependent manner (IC50, 10 microM).
(4) Somatostatin inhibited carbachol- and cholecystokinin octapeptide-induced pepsinogen secretion from dispersed gastric mucosal cells in a dose-dependent manner.
(5) The amplitudes of the a-wave and the 01 decreased in dose-dependent manners, but their changes were less striking than those of the 01 latency.
(6) A neodymium YAG (Nd:YAG) laser was evaluated in a dog ulcer model used in the same manner as is recommended for bleeding patients (power 55 W, divergence angle 4 degrees, with CO2 gas-jet assistance).
(7) Hemagglutinating (HA) activity of rubella virus was inactivated with 2-mercaptoethanol (2ME) in a dose-dependent manner.
(8) Enzyme prepared in this manner was homogeneous according to electrophoresis on sodium dodecyl sulfate-polyacrylamide gels and immunoelectrophoresis using antiserum directed against it.
(9) Loss of reduced protein thiols, as measured by binding of the thiol reagent iodoacetic acid to GPD, and loss of GPD enzymatic activity occurred in a dose-dependent manner.
(10) Inhibition of binding of [3H]TPA to the receptor preparation by tigliane and ingenane DTE correlates with irritant activity in vivo, while some daphnane and 1 alpha-alkyldaphnane DTE inhibit binding of [3H]TPA in a less pronounced manner but still are very irritant.
(11) All three organotins inhibited cardiac Na+,K(+)-ATPase, [3H]ouabain binding, K(+)-activated p-nitrophenyl phosphatase (K(+)-PNPPase) and oligomycin-sensitive (OS) and oligomycin-insensitive (OI) Mg(2+)-ATPase in a concentration-dependent manner.
(12) "With the advent of sophisticated data-processing capabilities (including big data), the big number-crunchers can detect, model and counter all manner of online activities just by detecting the behavioural patterns they see in the data and adjusting their tactics accordingly.
(13) The reductase in B. subtilis seemed to reduce ribonucleoside triphosphates in a similar manner to the enzyme in Lactobacillus leichmannii.
(14) At high luminances, the temporal, but not spatial, properties of this mechanism break down in a manner which had not been studied.Low-frequency inhibitory processThis process is manifest as a decrease in sensitivity from that of the simple excitatory process.
(15) Dialyzed crude enzyme extracts from yeast cells were found to destroy diacetyl in a manner quite similar to that of diacetyl reductase from Aerobacter aerogenes, and both the bacterial and the yeast extracts were stimulated significantly by the addition of reduced nicotinamide adenine dinucleotide (NADH).
(16) The liposomal thyroglobulin was hydrolyzed in a time-dependent manner in the fraction showing both radioactivity and acid phosphatase activity.
(17) The dual-probe system incorporates a central collimated probe for monitoring activity in the LV surrounded by an annular detector collimated in such a manner as to provide simultaneous real-time monitoring of the LV background activity.
(18) Cell culture experiments showed that CA III induced a 2- to 11-fold increase in [14C]HA synthesis by human synovial fibroblasts (SF) in a dose-dependent manner (P less than 0.001); erythrocyte CA I and CA II were inactive.
(19) Dopamine and SKF 82526 stimulated the release of inositol phosphates from added [3H]PIP2 in a concentration-dependent manner.
(20) We found that when CyA or FK was added to the culture throughout the experiment, the production of the factors with ECA by PBMC was inhibited in a dose-dependent manner.