(a.) Disposed to do harm, inflict suffering, or cause distress; actuated by extreme malevolence or enmity; virulently inimical; bent on evil; malicious.
(a.) Characterized or caused by evil intentions; pernicious.
(a.) Tending to produce death; threatening a fatal issue; virulent; as, malignant diphtheria.
(n.) A man of extrems enmity or evil intentions.
(n.) One of the adherents of Charles L. or Charles LL.; -- so called by the opposite party.
Example Sentences:
(1) In contrast to previous reports, these tumours were more malignant than osteosarcomas and showed a five-year survival rate of only 4-2 per cent.
(2) Oral administration in domestic cats causes malignant hepatomas and tumors of the esophagus and kidney.
(3) In view of reports of the reduction of telomeric repeats in human malignant tumors, we measured the lengths of telomeric repeats in 55 primary neuroblastomas.
(4) The frequency of gastric malignancies in the families of the women with gastric polyps was higher than in the controls and in men, 6.2, 3.1 and 2.4 percent, respectively (p less than 0.05, and p less than 0.025).
(5) In 60 rhesus monkeys with experimental renovascular malignant arterial hypertension (25 one-kidney and 35 two-kidney model animals), we studied the so-called 'hard exudates' or white retinal deposits in detail (by ophthalmoscopy, and stereoscopic color fundus photography and fluorescein fundus angiography, on long-term follow-up).
(6) The only localized tumors known to produce elevation of CEA above the levels observed in non malignant diseases are carcinomas of the large bowel and the pancreas.
(7) Normal cultured human epidermal melanocytes and melanoma cells derived from three different malignant melanomas were examined for synthesis of extracellular matrix components before and after treatment for one day with interferon-gamma, tumor necrosis factor-alpha, or both.
(8) The presence of these markers has facilitated the identification and characterization of the mononuclear cells in a number of animal and human lymphoid malignancies.
(9) Benign and malignant epithelial and soft tissue tumors of the skin were usually negatively stained with MoAb HMSA-2.
(10) HCT were classified by light microscopy as benign (n = 22), intermediate (n = 30), and malignant (n = 13).
(11) This case is unusual in that it demonstrated no malignant epithelium beyond that of a borderline tumor, but met the criteria of malignancy because of its invasiveness and metastasis.
(12) As novel antibody therapeutics are developed for different malignancies and require evaluation with cells previously uncharacterized as antibody-dependent cell-mediated cytotoxicity (ADCC) targets, efficient description of key parameters of the assay system expedites the preclinical assessment.
(13) The fragile site at 10q25 was expressed in larger proportions of malignant than normal cells.
(14) In the control group it was 18% and in other malignancies 20%.
(15) Total lactate dehydrogenase (LDH; EC 1.1.1.27) activity and the percentage distribution of LDH isoenzymes were determined in 127 patients with malignant diseases.
(16) In our opinion, a carcinologically "malignant" metastatic myxoma remains a questionable pathological entity.
(17) Hexokinase, phoshofructokinase, and aldolase appear to be rate-limiting in normal cervix epithelium; however, since the increase in activity of the first two in cancers was least of all the glycolytic enzymes, redundant enzyme synthesis probably occurs in the malignant cell for the enzymes catalysing reversible reactions.
(18) The flow cytometric measured DNA content (i.e., DNA index), S-fractions, and histopathologic malignancy grades were studied for ninety uterine cervical squamous cell carcinomas using tissue biopsies taken prior to radiotherapy.
(19) Changes in the plasma lipid composition are observed in patients and animals with malignancy and certain other diseases that are consistent with peroxidation of plasma lipoprotein lipids.
(20) It was difficult to assess the diagnosis of malignant mesothelioma on isolated differentiated mesothelial cells in pleural fluids or biopsies.
Sarcoma
Definition:
(n.) A tumor of fleshy consistence; -- formerly applied to many varieties of tumor, now restricted to a variety of malignant growth made up of cells resembling those of fetal development without any proper intercellular substance.
Example Sentences:
(1) A spindle cell sarcoma appeared 20 months after implantation of a pellet of 3-methylcholanthrene in the denervated foreleg of an adult frog, Rana pipiens.
(2) The p60v-src protein encoded by Prague Rous sarcoma virus was found to contain two sites of tyrosine phosphorylation.
(3) None of the compounds proved active against the replication of retroviruses (human immunodeficiency virus, murine sarcoma virus) at concentrations that were not toxic to the host cells.
(4) In the case of the reticulum cell sarcoma, the tumor had not reappeared in some of the animals two months after cessation of treatment.
(5) A young man being treated with primary adjuvant Adriamycin and DDP for osteogenic sarcoma is described who developed a gingival line which temporally was related to DDP administration.
(7) Autopsy revealed a primary intimal sarcoma with osteogenic elements arising in the posterior leaflet of the pulmonary valve and obstructing the main pulmonary artery and its right branch.
(8) These included 196 sarcomas, 20 carcinomas and 14 angiomas.
(9) In contrast, T lymphocyte cytolytic activity developed more slowly in regressing sarcomas and attained peak levels coincident with the beginning of tumor regression.
(10) Three of the tumours represented primary soft tissue lesions, while locally recurrent tumour or pulmonary metastases were studied from the 4 skeletal tumours, all of which had been diagnosed previously as Ewing's sarcomas.
(11) A hospital-based case-control study on soft tissue sarcomas (STS) was conducted in 1983-84 in Torino and in Padova (Italy).
(12) In the present study, we have compared the phosphorylation state of the fibronectin receptor in motile neural crest and somitic cells, in stationary somitic cells, and in Rous-sarcoma virus transformed-chick embryo fibroblasts, using immunoprecipitation following metabolic labeling.
(13) Subcutaneous polymorphic sarcomas were induced in 8 out 27 offspring of syrian golden Hamsters after treatment of pregnant mother animals at day 15 of gestation with Adenovirus 12.
(14) In cultures of medium ML-15 containing a feeder layer of Dog Sarcoma (DS) cells larvae successfully moulted and showed a small but significant increase in length.
(15) The radiological patterns of presentation of the gastrointestinal lesions of Kaposi's sarcoma are described, this being the most frequent location of the disease after the skin and lymph nodes.
(16) Tumor necrosis factor (TNF) has demonstrated antitumor activity against a variety of tumors and is particularly cytotoxic to capillary endothelial cells, which are the presumed cell of origin of Kaposi's sarcoma.
(17) Moloney sarcoma virus, however, does not induce myeloproliferation and leukemia in adult mice.
(18) Fusion of these segments created a DNA fragment in which coding regions similar to those observed in the viral oncogenes v-fes of the Gardner-Arnstein (GA) and Snyder-Theilen (ST) strains of feline sarcoma virus and v-fps found in Fujinami sarcoma virus could be identified.
(19) The distinction between this sarcoma and the Paget bone was clearer on CT than on MR.
(20) Ewing's sarcoma is considered a primary malignant tumor of bone.