(1) This substance stopped fetal and skin (MALME 3 line) fibroblast propagation.
(2) In maxicells, the resulting plasmid permitted tac12-promoted synthesis of two polypeptides, encoded by gene malM, with apparent molecular weights of 37 X 10(3) and 34.5 X 10(3).
(3) Smaller increases were noted with the cell lines RPMI 7951, HT 144, Malme-3M, MEL-2, and no significant increase was observed with MEL-5.
(4) Treatment of MALME-3 cells with BESPM resulted in an accumulation of N-acetylspermidine in cells and the enhanced excretion of putrescine, spermidine, and N-acetylspermidine into the medium.
(5) The malM gene, encoding a periplasmic protein of unknown function in Escherichia coli, is a highly conserved as genes encoding proteins of known function from the same region.
(6) Treatment of human MALME-3 melanoma cells with 10 microM N1,N11-bis(ethyl)norspermine (BENSPM) for 48-72 h increased SSAT activity by some 1000- to 4000-fold and enabled purification of the enzyme by established procedures--binding on immobilized spermine and elution with spermine followed by binding on Matrex Blue A and elution with coenzyme A.
(7) One malM mutation corresponding to an A.T----G.C transition showed a 10-fold-higher spontaneous reversion frequency than other such transitions in a wild-type background.
(8) From 1981, we changed a surgical procedure fro Gersony-Malm procedure to the posterior approach method, and a surgical technique from the deep hypothermia and the circulatory arrest to the moderate hypothermia and the pump perfusion.
(9) The patient was treated with repair using Gersony-Malm's method and plasty of SVC because of the stenosis of the common pulmonary vein's entrance to the SVC.
(10) In MALME-3 cells, SSAT accumulation was found to be differentially modulated by the BESPM homologues, N1,N11-bis-(ethyl)norspermine and N1,N14-bis-(ethyl)homospermine, which were 5-fold more and 9-fold less effective, respectively, than BESPM in increasing SSAT but similar in analogue uptake and effects on polyamine biosynthesis and cell growth inhibition.
(11) The intergenic region between lamB and the following gene, malM, comprises conserved segments, including one palindromic unit.
(12) They result in an increase in amount and specific activity of a MalM-LacZ hybrid protein.
(13) The complete malM open reading frame was cloned under control of the tac 12 promoter.
(14) Mutations affecting the hydrophobic core of the N-terminal extension of the MalM protein have been isolated.
(15) The calcium balance studies of Malm were re-analysed to quantify the seasonal variation he had demonstrated in one group of men.
(16) We show that the chromosomal malM gene is expressed as part of the malK-lamB operon, and that its product is periplasmic.
(17) Antiproliferative effects ranged from slowing of cell growth in the less SSAT responsive lines (LOX, SH-1) to total cessation of cell growth or overt cytotoxicity in the more potently SSAT responsive lines (MALME-3, Ebey).
(18) Finally, we demonstrate with nuclease S1 mapping experiments that the mRNA terminates at a typical rho-independent terminator located about 45 base-pairs beyond the end of gene malM, which is thus the last gene of the malK-lamB operon.
(19) We have subcloned and sequenced the genes malF and malM of Salmonella typhimurium, thereby completing the determination of the nucleotide sequence of its 'maltose B' regulon.
(20) They failed to kill autologous B cells, erythroid progenitors present in allogeneic bone marrow, and a number of cultured human tumor cells (Malme, CAKI) even after prolonged (36 h) co-culture.
Soft
Definition:
(superl.) Easily yielding to pressure; easily impressed, molded, or cut; not firm in resisting; impressible; yielding; also, malleable; -- opposed to hard; as, a soft bed; a soft peach; soft earth; soft wood or metal.
(superl.) Not rough, rugged, or harsh to the touch; smooth; delicate; fine; as, soft silk; a soft skin.
(superl.) Hence, agreeable to feel, taste, or inhale; not irritating to the tissues; as, a soft liniment; soft wines.
(superl.) Not harsh or offensive to the sight; not glaring; pleasing to the eye; not exciting by intensity of color or violent contrast; as, soft hues or tints.
(superl.) Not harsh or rough in sound; gentle and pleasing to the ear; flowing; as, soft whispers of music.
(superl.) Easily yielding; susceptible to influence; flexible; gentle; kind.
(superl.) Expressing gentleness, tenderness, or the like; mild; conciliatory; courteous; kind; as, soft eyes.
(superl.) Effeminate; not courageous or manly, weak.
(superl.) Having, or consisting of, a gentle curve or curves; not angular or abrupt; as, soft outlines.
(superl.) Not tinged with mineral salts; adapted to decompose soap; as, soft water is the best for washing.
(superl.) Applied to a palatal, a sibilant, or a dental consonant (as g in gem, c in cent, etc.) as distinguished from a guttural mute (as g in go, c in cone, etc.); -- opposed to hard.
(superl.) Belonging to the class of sonant elements as distinguished from the surd, and considered as involving less force in utterance; as, b, d, g, z, v, etc., in contrast with p, t, k, s, f, etc.
(n.) A soft or foolish person; an idiot.
(adv.) Softly; without roughness or harshness; gently; quietly.
(interj.) Be quiet; hold; stop; not so fast.
Example Sentences:
(1) In conclusion, the efficacy of free tissue transfer in the treatment of osteomyelitis is geared mainly at enabling the surgeon to perform a wide radical debridement of infected and nonviable soft tissue and bone.
(2) Bilateral symmetric soft-tissue masses posterior to the glandular tissue with accompanying calcifications should suggest the diagnosis.
(3) None of the other soft tissue layers-ameloblasts, stratum intermedium or dental follicle--immunostain for TGF-beta 1.
(4) The cotransfected cells do not grow in soft agar, but show enhanced soft agar growth relative to controls in the presence of added aFGF and heparin.
(5) It was hypothesized that compensatory restraining influences of surrounding soft tissues prevented a more severe facial malformation from occurring.
(6) After the diagnosis of a soft-tissue injury (sprain, strain, or contusion) has been made, treatment must include an initial 24- to 48-hour period of RICE.
(7) It is a specific clinical picture with extensive soft tissue gas and swelling of the forearm.
(8) Benign and malignant epithelial and soft tissue tumors of the skin were usually negatively stained with MoAb HMSA-2.
(9) The patient, a 12 year-old boy, showed a soft white yellowish mycotic excrescence with clear borders which had followed the introduction of a small piece of straw into the cornea.
(10) In open fractures especially in those with severe soft tissue damage, fracture stabilisation is best achieved by using external fixators.
(11) A distally based posterior tibial artery adipofascial flap with skin graft was used for the reconstruction of soft tissue defects over the Achilles tendon in three cases and over the heel in three cases.
(12) The third patient was using an extended-wear soft contact lens for correction of residual myopia.
(13) Computed tomography (CT) is the most sensitive radiologic study for detecting these tumors, which usually are small, round, sharply marginated, and of homogeneous soft tissue density.
(14) The latter indicated that, despite the smaller size of the digital image, they were adequate for resolving clinically significant soft-tissue densities.
(15) We isolated soft agar colonies (a-subclones) and sub-clones from foci (h-subclones) of both hybrids, and, as a control, subclones of cells from random areas without foci of one hybrid (BS181 p-subclones).
(16) Three of the tumours represented primary soft tissue lesions, while locally recurrent tumour or pulmonary metastases were studied from the 4 skeletal tumours, all of which had been diagnosed previously as Ewing's sarcomas.
(17) The technique is based on a multiple regression analysis of the renal curves and separate heart and soft tissue curves which together represent background activity.
(18) A hospital-based case-control study on soft tissue sarcomas (STS) was conducted in 1983-84 in Torino and in Padova (Italy).
(19) This phenomenon can have a special significance for defining the vitality in inflammation of bone tissue, in burns and in necrosis of soft tissues a.a. of the Achilles tendon.
(20) Thirty patients required a second operation to an area previously addressed reflecting inadequacies in technique, the unpredictability of bone grafts, and soft-tissue scarring.