(1) DMPDDF exhibited excellent growth inhibition of Manca human lymphoid leukemia and H35 hepatoma cells in culture.
(2) Intratumor as well as intraperitoneal administration of the human-mouse chimeric antibody repressed the tumor growth of Manca cells in nude mice.
(3) Varying the medium folic acid (PteGlu) concentration over the range of 0.5 to 100 microM increasingly blocks the growth inhibitory effects of the individual antifolates in Manca human lymphoma cells, but increasingly enhances the synergistic interaction of both TMTX + DDATHF and TMTX+ PDDF combinations.
(4) In tests against other folate-utilizing enzymes, 11a and 11b were found to be inhibitors of glycinamide ribonucleotide formyltransferase (GAR formyltransferase) from one bacterial (Lactobacillus casei) and two mammalian (Manca and L1210) sources with 11a being decidedly more inhibitory than 11b.
(5) Using probes that span greater than 120 kilobases across the human beta-globin gene locus, we show that the majority of this domain replicates in early S phase in the human erythroleukemia cell line K562 and in middle-to-late S phase in the lymphoid cell line Manca.
(6) In addition, compound 5 also failed to inhibit glycinamide ribonucleotide formyltransferase from L. casei and from Manca cells.
(7) The target compound 2, its aromatic precursor 18, and the nonclassical analogue 4 were evaluated as inhibitors of the growth of Manca human lymphoma cells and also as inhibitors of human dihydrofolate reductase, human thymidylate synthase, glycinamide ribonucleotide formyltransferase, and aminoimidazole carboxamide ribonucleotide formyltransferase.
(8) The title compound was tested as an inhibitor of the growth of Manca human lymphoma cells and also as an inhibitor of TS from Manca cells and Lactobacillus casei and was found to be inactive.
(9) In Manca cell extracts, the (6S) form is more potent than the (6R) form whereas in the murine system the reverse is true.
(10) The regulation of P0 RNA was studied in the B-cell lymphoma cell line Manca, in which only the translocated c-myc allele lacking exon 1 was thought to be active.
(11) A high-resolution two-dimensional polyacrylamide gel electrophoresis (2D-PAGE) was used for total cellular polypeptide mapping of two established lymphoma cell lines; MANCA, a Burkitt's line representing a high grade lymphoma (HGL) and WSU-NHL (nodular histiocytic lymphoma) representing an intermediate grade lymphoma (IGL).
(12) Aminopterin was accumulated mainly as the diglutamate, particularly in Manca cells where 70% of total drug was in the diglutamate form within the first 3 h and remained the predominant form for 24 h.(ABSTRACT TRUNCATED AT 400 WORDS)
(13) Growth-inhibition studies with H35 hepatoma, Manca human lymphoma, and CCRF-CEM human leukemia cells established greater cytotoxic effects with compounds 3-5 than with compounds 1 and 2. gamma-Methyleneglutamate derivatives 3-5 were transported to H35 hepatoma cells better than MTX or beta-hydroxyglutamate derivatives 1 and 2.
(14) Cytotoxicity of the four analogues against the murine L1210 leukemia and the human Manca B cell leukemia, as determined by a 3-h clonogenic assay, showed aminopterin and the two 10-deazaaminopterin compounds to be approximately equivalent for each cell type and were 3- to 10- (L1210) and 7- to 14-fold (Manca) more potent than methotrexate.
(15) Comparisons have been made of the levels of transcripts of the translocated c-myc gene in ST486 and CA46, where the gene is not associated with the heavy chain enhancer, with its expression in the Manca cell, in which it is.
(16) The maximum relative extents of total polyglutamate accumulation in L1210 cells were 85 to 95% of the total drug at 24 h. In Manca cells, the maximum polyglutamate accumulation was also 85 to 95%, but this was obtained by 6 h. However, in Sarcoma 180 cells, only aminopterin polyglutamates reached a similar maximum percentage of accumulation, while lower relative polyglutamate levels were achieved with the other analogues.
(17) Biodistribution and specificity of targeting were assessed by comparison among three cells, A4, lung cancer SBC-3 (c-erbB-2 weakly positive) and B-lymphoblastoid Manca cells (c-erbB-2 negative).
(18) Manca cell growth is inhibited 50% by HPteGlu and (6R,S)-5-methyl-H4HPteGlu at 6 and 8 microM, respectively.
(19) In spite of what was detected in a human lymphoma cell line (Manca) carrying a similar rearrangement, in this case the amount of c-myc transcript was not increased compared to an Epstein-Barr virus-transformed normal lymphoblastoid cell line obtained from the same patient.
(20) The in vivo administration of a recently described recombinant human-mouse chimeric antibody specific for a human common acute lymphocytic leukemia antigen (cALLA) caused significant inhibition of the tumorigenic growth of human leukemic cells (Manca cells, expressing cALLA on the surface) which were implanted into nude mice.
Manta
Definition:
(n.) See Coleoptera and Sea devil.
Example Sentences:
(1) Praia do Cabeço is popular with clammers but also families and strollers, and runs from Monte Gordo to Manta Rota.
(2) The parameatal foreskin flap, both in the form of a manta-wing and in extended circumferential form, appears to have an enough microcirculation suitable for one-stage repair (OUPF II and OUPF IV, respectively) of hypospadias.
(3) The trade is on the increase, with Mozambique recording an 86% decline in sightings of the fish over the past eight years, but manta rays are very important for tourism and attract divers who will pay a lot to see them.
(4) Anderson-TAMVEC (Houston and College Station, Texas), University of Washington (Seattle, Washington), and MANTA (Naval Research Laboratory, Washington, D.C.).
(5) Conservationists have called for legal protection of species such as sharks and manta rays, the banning of gillnets – which create a wall of netting to catch fish – and greater education of and alternative livelihoods for fishermen.
(6) The determination of the RBE for the MANTA fast neutrons produced by NRL is inprogress, with the model system using tumor cell population kinetic response patterns assayed in vitro after irradiation in vivo.
(7) Those looking for a tapering would welcome the forthcoming drop in the monthly purchase amount,” said Grant Lewis and Mantas Vanagas, at Daiwa Capital Markets.
(8) There is a manta ray inside the tank who is a music producer called Tony Reason.
(9) Photograph: Alamy She continued: "People come from all over the world to enjoy diving with sharks and manta rays, but if this goes on, they won't be there any more.
(10) The Cites meeting is also considering protection for manta rays, which are being fished for their gill plates, sold in China as medicine and claimed to treat a range of health complaints from asthma to chicken pox and even cancer.
(11) Marshall, principal scientist for the manta ray programme, said: "We're looking at decimation in the next decade or decade-and-a-half.
(12) I am keen to see trade controls introduced for vulnerable and endangered species like porbeagle, hammerhead and oceanic whitetip sharks and manta rays."
(13) A system has been developed for the computer generation of dose distributions for the MANTA-NRL fast-neutron radiotherapy beam.
(14) Helen got scuba qualified, and we spent hours diving alongside whale sharks and manta rays, but the sea lions stood out as our finest animal encounter.
(15) But this burgeoning trade along the Mozambican coast is putting precious species such as manta rays in existential danger, according to local conservationists.
(16) But it is an open secret that Chinese syndicates are supplying improved fishing nets, buying shark fins and manta ray "wing" tips and shipping them back to Asia, where there is increasing demand for delicacies such as shark fin soup.
(17) Time is running out for the manta ray, a beautiful fish with big, triangular pectoral "wings" that has a meagre reproductive cycle.
(18) The displacement correction factor to be used for analysis of fast-neutron dosimetric measurements using air-filled EG and G tissue-equivalent ion chambers in a tissue-equivalent phantom has been investigated using the MANTA neutron radiotherapy beam generated by 35-MeV deuterons on a thick Be target.
(19) There’s whale watching, swimming with dolphins, and diving with manta rays to be had, plus canyoning and kayaking.
(20) First, the centrality of the state as the driver of modernisation, a tenet linked to anti-imperialism vis-a-vis the US (closing the Manta military base; the aggressive struggle against American energy group Chevron and the environmental destruction it caused in the Amazon; and granting asylum to Julian Assange).