(a.) Designated or distinguished by, or as by, a mark; hence; noticeable; conspicuous; as, a marked card; a marked coin; a marked instance.
Example Sentences:
(1) Herpesviruses such as EBV, HSV, and human herpes virus-6 (HHV-6) have a marked tropism for cells of the immune system and therefore infection by these viruses may result in alterations of immune functions, leading at times to a state of immunosuppression.
(2) Patient plasma samples demonstrated evidence of marked complement activation, with 3-fold elevations of C3a desArg concentrations by the 8th day of therapy.
(3) Following in vitro C activation in NHS by delta IgG, the 40 KD C4d component increased markedly.
(4) However, when cross-linked to anti-CD4 or anti-CD8 antibodies a markedly enhanced proliferation of the corresponding subpopulation is observed.
(5) When chimeric animals were subjected to a lethal challenge of endotoxin, their response was markedly altered by the transferred lymphoid cells.
(6) Increased dietary protein intake led to increased MDA per nephron, increased urinary excretion of MDA, and increased MDA per milligram protein in subtotally nephrectomized animals, and markedly increased the glutathione redox ratio.
(7) Cyclic AMP stimulated phosphorylation by [gamma-32P]ATP of two proteins of apparent Mr = 20,000 and 7,000 that were concentrated in sarcoplasmic reticulum, but the stimulation was markedly dependent on the presence of added soluble cyclic AMP-dependent protein kinase.
(8) Surprisingly, the clonal elimination of V beta 6+ cells is preceded by marked expansion of these cells.
(9) Muscle weakness and atrophy were most marked in the distal parts of the legs, especially in the gastrocnemius and soleus muscles, and then spread to the thighs and gluteal muscles.
(10) of PLA2 caused marked degranulation of mast cells in the rat mesentery which was facilitated by addition of calcium ion (10 mM) but antagonized by pretreating with three antiinflammatory agents.
(11) report the complications registered, in particular: lead's displacing 6.2%, run away 0.7%, marked hyperthermya 0.0%, haemorrage 0.4%, wound dehiscence 0.3%, asectic necrosis by decubitus 5%, septic necrosis 0.3%, perforation of the heart 0.2%, pulmonary embolism 0.1%.
(12) Marked enhancement of IFN-gamma production by T cells was seen in the presence of as little as 0.3% thymic DC.
(13) This effect was more marked in breast cancer patients which may explain our earlier finding that women with upper body fat localization are at increased risk for developing breast cancer.
(14) Completeness of isolation of the coronary and systemic circulations was shown by the marked difference in appearance times between the reflex hypotensive responses from catecholamine injections into the isolated coronary circulation and the direct hypertensive response from a similar injection when the circulations were connected as well as by the marked difference between the pressure pulses recorded simultaneously on both sides of the aortic balloon separating the two circulations.4.
(15) A marked overlap of input from the two eyes is an unusual feature for a diprotodont marsupial and has previously been seen only in the feathertail glider.
(16) The erythrocyte sedimentation rate is almost always markedly elevated.
(18) Sixteen patients (27%) manifested anomalies of the urinary tract: 12 had markedly altered kidneys, 8 of which were unilateral and ipsilateral to the diaphragmatic defect.
(19) Her muscle weakness and hyperCKemia markedly improved by corticosteroid therapy, suggesting that the diagnosis was compatible with polymyositis (PM).
(20) The introduction of intravenous, high-dose thrombolytic therapy during a brief period has markedly reduced mortality of patients with acute myocardial infarction.
Modest
Definition:
(a.) Restraining within due limits of propriety; not forward, bold, boastful, or presumptious; rather retiring than pushing one's self forward; not obstructive; as, a modest youth; a modest man.
(a.) Observing the proprieties of the sex; not unwomanly in act or bearing; free from undue familiarity, indecency, or lewdness; decent in speech and demeanor; -- said of a woman.
(a.) Evincing modestly in the actor, author, or speaker; not showing presumption; not excessive or extreme; moderate; as, a modest request; modest joy.
Example Sentences:
(1) Incubation with IFN alpha or IFN gamma for 24 h resulted in only modest cytokinetic alterations, and they did not modify the effects of FUra.
(2) The active agents modestly improved treadmill exercise duration time until 1 mm ST segment depression (3%), and only propranolol and diltiazem had significant effects.
(3) Brown's model, which goes far further than those from any other senior Labour figure, and the modest new income tax powers for Holyrood devised when he was prime minister, edge the party much closer to the quasi-federal plans championed by the Liberal Democrats.
(4) The standard varies from modest to lavish – choose carefully and you could be staying in an antique-filled room with your host's paintings on the walls, and breakfasting on the veranda of a tropical garden.
(5) Bupropion, in contrast, had a modest effect only in CD-1 mice.
(6) These data support a modest role for alpha 1-adrenergic coronary vasoconstriction during exercise but fail to document an additional role for postsynaptic alpha 2-adrenergic coronary vasoconstriction during exercise.
(7) Alterations in mean systolic blood pressure appeared to be modest, consisting of a 10 percent decrease from the control level, related to sedation, and a 10 percent rise from baseline during the procedure, associated with a concomitant mild tachycardia.
(8) The patient made modest improvement with high-dose intravenous steroids.
(9) Modest reductions in renal function as measured by clearances of inulin and p-aminohippurate occurred acutely only in the patients with renal impairment.
(10) Although the debate in the US has led to some piecemeal reforms – including the USA Freedom Act and modest policy changes – many of the most intrusive government surveillance programs remain largely intact.
(11) Ultimately, both Geffen and Browne turned out to be correct: establishing the pattern for Zevon's career, the albums sold modestly but the critics loved them.
(12) Simultaneous metabolic studies of human normal fibrinogen and asialofibrinogen in rabbits revealed only a modest decrease in the half-life of the asialoprotein compared to the intact protein, with no preferential uptake of the asialo-derivative by the liver.
(13) Levels of involvement in the program were modest, with only 16% of those screened having over 10 clinical contacts and 24% still involved after 3 months.
(14) Testosterone and estrogen administration at low or modest doses to individuals with the capacity to produce GH causes GH production and IGF-I levels to increase.
(15) The more modest effect of (n-3) fatty acid supplementation in decreasing LTB4 generation was not due to blockade of the cyclooxygenase pathway.
(16) The effect of volume expansion on sodium, calcium and magnesium remaining in the proximal tubule was relatively modest and not affected by furosemide.
(17) On the other side of the Atlantic, a more modest, quieter challenger plans to take on the US electric car giant.
(18) In conclusion, a zipper technique has been outlined that allows effective continuing drainage of the septic abdomen, permits early diagnosis of organ damage, is rapid and cost effective, minimizes ventilator dependency and gastrointestinal complications, is well tolerated by the patients, and has produced a modest 65 per cent survival rate in the first 34 critically ill patients in whom it was used.
(19) In order to improve the modest oral activity of PGE2 as an inhibitor of gastric acid secretion, analogs were prepared and tested orally in histamine-challenged rats.
(20) Specific binding of insulin did not differ between control and modestly insulinopenic diabetics but was increased significantly in the severely insulinopenic diabetics.