(v. t.) To have in the mind, as a purpose, intention, etc.; to intend; to purpose; to design; as, what do you mean to do ?
(v. t.) To signify; to indicate; to import; to denote.
(v. i.) To have a purpose or intention.
(superl.) Destitute of distinction or eminence; common; low; vulgar; humble.
(superl.) Wanting dignity of mind; low-minded; base; destitute of honor; spiritless; as, a mean motive.
(superl.) Of little value or account; worthy of little or no regard; contemptible; despicable.
(superl.) Of poor quality; as, mean fare.
(superl.) Penurious; stingy; close-fisted; illiberal; as, mean hospitality.
(a.) Occupying a middle position; middle; being about midway between extremes.
(a.) Intermediate in excellence of any kind.
(a.) Average; having an intermediate value between two extremes, or between the several successive values of a variable quantity during one cycle of variation; as, mean distance; mean motion; mean solar day.
(n.) That which is mean, or intermediate, between two extremes of place, time, or number; the middle point or place; middle rate or degree; mediocrity; medium; absence of extremes or excess; moderation; measure.
(n.) A quantity having an intermediate value between several others, from which it is derived, and of which it expresses the resultant value; usually, unless otherwise specified, it is the simple average, formed by adding the quantities together and dividing by their number, which is called an arithmetical mean. A geometrical mean is the square root of the product of the quantities.
(n.) That through which, or by the help of which, an end is attained; something tending to an object desired; intermediate agency or measure; necessary condition or coagent; instrument.
(n.) Hence: Resources; property, revenue, or the like, considered as the condition of easy livelihood, or an instrumentality at command for effecting any purpose; disposable force or substance.
(n.) A part, whether alto or tenor, intermediate between the soprano and base; a middle part.
(n.) Meantime; meanwhile.
(n.) A mediator; a go-between.
Example Sentences:
(1) Thirty-two patients (10 male, 22 female; age 37-82 years) undergoing maintenance haemodialysis or haemofiltration were studied by means of Holter device capable of simultaneously analysing rhythm and ST-changes in three leads.
(2) Age difference did not affect the mean dose-effect response.
(3) Although the mean values for all hemodynamic variables between the two placebo periods were minimally changed, the differences in individual patients were striking.
(4) Propranolol resulted in a significantly lower mean hourly, mean 24 h and minimum heart rate.
(5) Which means Seattle can't give Jones room to make 13-yard catches as they just did.
(6) A group I subset (six animals), for which predominant cultivable microbiota was described, had a mean GI of 2.4.
(7) Then the esophagogastric variceal network was thrombosed by means of a catheter introduced during laparotomy, which created a portoazygos disconnection.
(8) The intrauterine mean active pressure (MAP) in the nulliparous group was 1.51 kPa (SD 0.45) in the first stage and 2.71 kPa (SD 0.77) in the second stage.
(9) In the group of high myopia (over 20 D), the mean correction was 13.4 D. In the group with refraction between 0 and 6 D, 88% of the eyes treated had attained a correction between -1 and +1 D 3 months postoperatively.
(10) That means deciding what job they’d like to have and outlining the steps they’ll need to take to achieve it.
(11) The difference in BP between a hospital casual reading and the mean 24 hour ambulatory reading was reduced only by atenolol.
(12) Until the 1960's there was great confusion, both within and between countries, on the meaning of diagnostic terms such as emphysema, asthma, and chronic brochitis.
(13) There were 12 males, 6 females, with mean age of 55.1 yrs (range 39-77 yrs).
(14) Measurement of urinary GGT levels represents a means by which proximal tubular disease in equidae could be diagnosed in its developmental stages.
(15) However, there was no statistically significant difference in mean areas under the LH and FSH curves in the GnRH-treated groups.
(16) Although lorazepam and haloperidol produced an equivalent mean decrease in aggression, significantly more subjects who received lorazepam had a greater decrease in aggression ratings than haloperidol recipients; this effect was independent of sedation.
(17) The mean and median values in the nondiabetic group are higher than in previously published reports.
(18) The way we are going to pay for that is by making the rules the same for people who go into care homes as for people who get care at their home, and by means-testing the winter fuel payment, which currently isn’t.” Hunt said the plan showed the Conservatives were capable of making difficult choices.
(19) Taken together these results are consistent with the view that primary CTL, as well as long term cloned CTL cell lines, exercise their cytolytic activity by means of perforin.
(20) Evidence is presented in support of the hypothesis that fresh bat guano serves as a means of pathogenic fungi dissemination in caves.
Mediate
Definition:
(a.) Being between the two extremes; middle; interposed; intervening; intermediate.
(a.) Acting by means, or by an intervening cause or instrument; not direct or immediate; acting or suffering through an intervening agent or condition.
(a.) Gained or effected by a medium or condition.
(a.) To be in the middle, or between two; to intervene.
(a.) To interpose between parties, as the equal friend of each, esp. for the purpose of effecting a reconciliation or agreement; as, to mediate between nations.
(v. t.) To effect by mediation or interposition; to bring about as a mediator, instrument, or means; as, to mediate a peace.
(v. t.) To divide into two equal parts.
Example Sentences:
(1) Stimulation of human leukocytes with various chemical mediators such as TPA, f-Met-Leu-Phe, LTB4, etc.
(2) Fibulin is a potential mediator of interactions between adhesion receptors and the cytoskeleton.
(3) Patients with papillary carcinoma with a good cell-mediated immune response occurred with much lower infiltration of the tumor boundary with lymphocyte whereas the follicular carcinoma less cell-mediated immunity was associated with dense lymphocytic infiltration, suggesting the biological relevance of lymphocytic infiltration may be different for the two histologic variants.
(4) The hypothesis that proteins are critical targets in free radical mediated cytolysis was tested using U937 mononuclear phagocytes as targets and iron together with hydrogen peroxide to generate radicals.
(5) We have investigated the effect of methimazole (MMI) on cell-mediated immunity and ascertained the mechanisms of immunosuppression produced by the drug.
(6) We determined whether serological investigations can assist to distinguish between chronic idiopathic autoimmune thrombocytopenia (cAITP) and immune-mediated thrombocytopenia in patients at risk to develop systemic lupus erythematosus (SLE); 82 patients were seen in this institution for the evaluation of immune thrombocytopenia.
(7) IgE-mediated acute systemic reactions to penicillin continue to be an important clinical problem.
(8) This induction is sensitive to actinomycin D but not to protein synthesis inhibitor puromycin, indicating an effect of estradiol at the transcriptional level, possibly mediated by the estrogen receptor.
(9) We sought additional evidence for an inverse relationship between functional CTL-target cell affinity on the one hand, and susceptibility of the CTL-mediated killing to inhibition by alpha LFA-1 and alpha Lyt-2,3 monoclonal antibodies on the other hand.
(10) Mannose receptor mediated uptake by the reticuloendothelial system has been suggested as an explanation for the rapid removal of ricin A chain antibody conjugates from the circulation after their administration.
(11) However, direct measurements of mediator release should be carried out to reach a firm conclusion.
(12) In addition to their involvement in thrombosis, activated platelets release growth factors, most notably a platelet-derived growth factor (PDGF) which may be the principal mediator of smooth muscle cell migration from the media into the intima and of smooth muscle cell proliferation in the intima as well as of vasoconstriction.
(13) Glutathion peroxidase and p-phenylenediamide-mediated peroxidase (PPD-peroxidase) were normal in leucocytes of 1 HPS patient.
(14) But MH162 was more effective than MRK16 in lymphocyte-mediated lysis of the MDR cells.
(15) Thus, human bronchial epithelial cells can express the IL-8 gene, with expression in response to the inflammatory mediator TNF regulated mainly at the transcriptional level, and with elements within the 5'-flanking region of the gene that are directly or indirectly modulated by the TNF signal.
(16) Tumour necrosis factor (TNF), a polypeptide produced by mononuclear phagocytes, has been implicated as an important mediator of inflammatory processes and of clinical manifestations in acute infectious diseases.
(17) From these results, it was suggested that the inhibitory effect of Cd on in vitro calcification of MC3T3-E1 cells may be due to both a depression of cell-mediated calcification and a decrease in physiochemical mineral deposition.
(18) injection of various inflammatory mediators, the vasopressor effect of i.a.
(19) It is concluded that fibroblast replication is an important mechanism leading to the pathologic fibrosis seen in graft versus host disease and, by analogy, probably other types of immunologically mediated fibrosis.
(20) The authors followed up the occurrence of inflammation-mediated osteopenia (IMO) in young and adult rats weighing 50 g and 150 g, respectively.