(v. t.) To have in the mind, as a purpose, intention, etc.; to intend; to purpose; to design; as, what do you mean to do ?
(v. t.) To signify; to indicate; to import; to denote.
(v. i.) To have a purpose or intention.
(superl.) Destitute of distinction or eminence; common; low; vulgar; humble.
(superl.) Wanting dignity of mind; low-minded; base; destitute of honor; spiritless; as, a mean motive.
(superl.) Of little value or account; worthy of little or no regard; contemptible; despicable.
(superl.) Of poor quality; as, mean fare.
(superl.) Penurious; stingy; close-fisted; illiberal; as, mean hospitality.
(a.) Occupying a middle position; middle; being about midway between extremes.
(a.) Intermediate in excellence of any kind.
(a.) Average; having an intermediate value between two extremes, or between the several successive values of a variable quantity during one cycle of variation; as, mean distance; mean motion; mean solar day.
(n.) That which is mean, or intermediate, between two extremes of place, time, or number; the middle point or place; middle rate or degree; mediocrity; medium; absence of extremes or excess; moderation; measure.
(n.) A quantity having an intermediate value between several others, from which it is derived, and of which it expresses the resultant value; usually, unless otherwise specified, it is the simple average, formed by adding the quantities together and dividing by their number, which is called an arithmetical mean. A geometrical mean is the square root of the product of the quantities.
(n.) That through which, or by the help of which, an end is attained; something tending to an object desired; intermediate agency or measure; necessary condition or coagent; instrument.
(n.) Hence: Resources; property, revenue, or the like, considered as the condition of easy livelihood, or an instrumentality at command for effecting any purpose; disposable force or substance.
(n.) A part, whether alto or tenor, intermediate between the soprano and base; a middle part.
(n.) Meantime; meanwhile.
(n.) A mediator; a go-between.
Example Sentences:
(1) Thirty-two patients (10 male, 22 female; age 37-82 years) undergoing maintenance haemodialysis or haemofiltration were studied by means of Holter device capable of simultaneously analysing rhythm and ST-changes in three leads.
(2) Age difference did not affect the mean dose-effect response.
(3) Although the mean values for all hemodynamic variables between the two placebo periods were minimally changed, the differences in individual patients were striking.
(4) Propranolol resulted in a significantly lower mean hourly, mean 24 h and minimum heart rate.
(5) Which means Seattle can't give Jones room to make 13-yard catches as they just did.
(6) A group I subset (six animals), for which predominant cultivable microbiota was described, had a mean GI of 2.4.
(7) Then the esophagogastric variceal network was thrombosed by means of a catheter introduced during laparotomy, which created a portoazygos disconnection.
(8) The intrauterine mean active pressure (MAP) in the nulliparous group was 1.51 kPa (SD 0.45) in the first stage and 2.71 kPa (SD 0.77) in the second stage.
(9) In the group of high myopia (over 20 D), the mean correction was 13.4 D. In the group with refraction between 0 and 6 D, 88% of the eyes treated had attained a correction between -1 and +1 D 3 months postoperatively.
(10) That means deciding what job they’d like to have and outlining the steps they’ll need to take to achieve it.
(11) The difference in BP between a hospital casual reading and the mean 24 hour ambulatory reading was reduced only by atenolol.
(12) Until the 1960's there was great confusion, both within and between countries, on the meaning of diagnostic terms such as emphysema, asthma, and chronic brochitis.
(13) There were 12 males, 6 females, with mean age of 55.1 yrs (range 39-77 yrs).
(14) Measurement of urinary GGT levels represents a means by which proximal tubular disease in equidae could be diagnosed in its developmental stages.
(15) However, there was no statistically significant difference in mean areas under the LH and FSH curves in the GnRH-treated groups.
(16) Although lorazepam and haloperidol produced an equivalent mean decrease in aggression, significantly more subjects who received lorazepam had a greater decrease in aggression ratings than haloperidol recipients; this effect was independent of sedation.
(17) The mean and median values in the nondiabetic group are higher than in previously published reports.
(18) The way we are going to pay for that is by making the rules the same for people who go into care homes as for people who get care at their home, and by means-testing the winter fuel payment, which currently isn’t.” Hunt said the plan showed the Conservatives were capable of making difficult choices.
(19) Taken together these results are consistent with the view that primary CTL, as well as long term cloned CTL cell lines, exercise their cytolytic activity by means of perforin.
(20) Evidence is presented in support of the hypothesis that fresh bat guano serves as a means of pathogenic fungi dissemination in caves.
Tight
Definition:
() of Tie
() p. p. of Tie.
(superl.) Firmly held together; compact; not loose or open; as, tight cloth; a tight knot.
(superl.) Close, so as not to admit the passage of a liquid or other fluid; not leaky; as, a tight ship; a tight cask; a tight room; -- often used in this sense as the second member of a compound; as, water-tight; air-tight.
(superl.) Fitting close, or too close, to the body; as, a tight coat or other garment.
(superl.) Not ragged; whole; neat; tidy.
(superl.) Close; parsimonious; saving; as, a man tight in his dealings.
(superl.) Not slack or loose; firmly stretched; taut; -- applied to a rope, chain, or the like, extended or stretched out.
(superl.) Handy; adroit; brisk.
(superl.) Somewhat intoxicated; tipsy.
(superl.) Pressing; stringent; not easy; firmly held; dear; -- said of money or the money market. Cf. Easy, 7.
(v. t.) To tighten.
Example Sentences:
(1) Freshly isolated sarcoplasmic reticulum vesicles contain 0.05 mol of tightly bound ADP and 0.03 mol of tightly bound ATP per mol of Ca2+, Mg2+-ATPase (ATP phosphohydrolase, EC 3.6.1.3).
(2) The expression of the Pgp isoforms appears to be tightly regulated and, at least in some cells, under complex hormonal control.
(3) Whereas the tight junctions of endoneurial capillaries are known to prevent certain blood-borne substances from entering the endoneurium, it was not clear whether the permeability of the pulpal capillaries, which are distant from the nerve fibres, could affect the nerve fibre environment.
(4) The cells are predominantly monopolar, tightly packed, and are flattened at the outer border of the ring.
(5) These data indicate that topoisomerase I and RNA polymerase I are tightly complexed both in vivo and in vitro, and suggest a role for DNA topoisomerase I in the transcription of ribosomal genes.
(6) Immunofluorescence and immunoelectronmicroscopy experiments demonstrated that while tight junctions demarcate PAS-O distribution in confluent cultures, apical polarity could be established at low culture densities when cells could not form tight junctions with neighboring cells.
(7) Investigations have been made to determine the identity and binding characteristics of the pterins that are bound tightly to dihydrofolate reductases which are isolated from vertebrate sources by a well established procedure.
(8) At all times, a tight inverse correlation exists between ATP and IMP concentrations.
(9) Recently, a gene for ITD (DYT1) in a non-Jewish kindred was located on chromosome 9q32-34, with tight linkage to the gene encoding gelsolin (GSN).
(10) This study investigates the use of the incentive inspirometer to observe the effects of tight versus loose clothing on inhalation volume with 17 volunteer subjects.
(11) In contrast, interchange of the histones and tightly bound non-histone protein DNA complexes from hormone-withdrawn and estrogen-stimulated chromatins during reconstitution did not affect the level of mRNAOV sequences produced.
(12) Using microelectrodes and various microscopic techniques active Na+ absorption as well as K+ secretion has been localized to the principal cells, while Cl- absorption was found to proceed largely, though not exclusively, through the tight junctions between cells.
(13) The successful establishment of a postcrisis SV-40 T antigen transformed epithelial cell line, 1HAEo-, which retains tight junctions and vectorial ion transport, is described.
(14) The present investigation shows that the intramembranous proteins of tight and gap junctions are mobile structures within the fluid membrane.
(15) In contrast, after incubation with 0.5% DOC, the core microfilaments are no longer tightly bundled yet the lateral arms remain attached with a distinct 33-nm periodicity.
(16) The data collected by several approaches reveal that assembly and maturation of vaccinia involves a tightly coupled sequence of interrelated events including the assembly of the envelope, post-translational cleavage of several virion polypeptides, and induction of the core enzymes.
(17) The tight coupling between neuronal activity and oxidative energy metabolism forms the basis for the use of cytochrome oxidase as an endogenous metabolic marker for neurons.
(18) When using a nylon thread for the attachment of a pseudophakos to the iris, it may happen that the suture is slung tightly around the implant-lens.
(19) Some antibodies and other proteins bind tightly to nitrocellulose and dissociation of these proteins by Tween 20 is barely detectable.
(20) Independent experts warn that rumours and deliberate misinformation about the regime are rife, partly because it is impossible to verify or disprove most stories about the tightly controlled country's elite.