(a.) Being between the two extremes; middle; interposed; intervening; intermediate.
(a.) Acting by means, or by an intervening cause or instrument; not direct or immediate; acting or suffering through an intervening agent or condition.
(a.) Gained or effected by a medium or condition.
(a.) To be in the middle, or between two; to intervene.
(a.) To interpose between parties, as the equal friend of each, esp. for the purpose of effecting a reconciliation or agreement; as, to mediate between nations.
(v. t.) To effect by mediation or interposition; to bring about as a mediator, instrument, or means; as, to mediate a peace.
(v. t.) To divide into two equal parts.
Example Sentences:
(1) Stimulation of human leukocytes with various chemical mediators such as TPA, f-Met-Leu-Phe, LTB4, etc.
(2) Fibulin is a potential mediator of interactions between adhesion receptors and the cytoskeleton.
(3) Patients with papillary carcinoma with a good cell-mediated immune response occurred with much lower infiltration of the tumor boundary with lymphocyte whereas the follicular carcinoma less cell-mediated immunity was associated with dense lymphocytic infiltration, suggesting the biological relevance of lymphocytic infiltration may be different for the two histologic variants.
(4) The hypothesis that proteins are critical targets in free radical mediated cytolysis was tested using U937 mononuclear phagocytes as targets and iron together with hydrogen peroxide to generate radicals.
(5) We have investigated the effect of methimazole (MMI) on cell-mediated immunity and ascertained the mechanisms of immunosuppression produced by the drug.
(6) We determined whether serological investigations can assist to distinguish between chronic idiopathic autoimmune thrombocytopenia (cAITP) and immune-mediated thrombocytopenia in patients at risk to develop systemic lupus erythematosus (SLE); 82 patients were seen in this institution for the evaluation of immune thrombocytopenia.
(7) IgE-mediated acute systemic reactions to penicillin continue to be an important clinical problem.
(8) This induction is sensitive to actinomycin D but not to protein synthesis inhibitor puromycin, indicating an effect of estradiol at the transcriptional level, possibly mediated by the estrogen receptor.
(9) We sought additional evidence for an inverse relationship between functional CTL-target cell affinity on the one hand, and susceptibility of the CTL-mediated killing to inhibition by alpha LFA-1 and alpha Lyt-2,3 monoclonal antibodies on the other hand.
(10) Mannose receptor mediated uptake by the reticuloendothelial system has been suggested as an explanation for the rapid removal of ricin A chain antibody conjugates from the circulation after their administration.
(11) However, direct measurements of mediator release should be carried out to reach a firm conclusion.
(12) In addition to their involvement in thrombosis, activated platelets release growth factors, most notably a platelet-derived growth factor (PDGF) which may be the principal mediator of smooth muscle cell migration from the media into the intima and of smooth muscle cell proliferation in the intima as well as of vasoconstriction.
(13) Glutathion peroxidase and p-phenylenediamide-mediated peroxidase (PPD-peroxidase) were normal in leucocytes of 1 HPS patient.
(14) But MH162 was more effective than MRK16 in lymphocyte-mediated lysis of the MDR cells.
(15) Thus, human bronchial epithelial cells can express the IL-8 gene, with expression in response to the inflammatory mediator TNF regulated mainly at the transcriptional level, and with elements within the 5'-flanking region of the gene that are directly or indirectly modulated by the TNF signal.
(16) Tumour necrosis factor (TNF), a polypeptide produced by mononuclear phagocytes, has been implicated as an important mediator of inflammatory processes and of clinical manifestations in acute infectious diseases.
(17) From these results, it was suggested that the inhibitory effect of Cd on in vitro calcification of MC3T3-E1 cells may be due to both a depression of cell-mediated calcification and a decrease in physiochemical mineral deposition.
(18) injection of various inflammatory mediators, the vasopressor effect of i.a.
(19) It is concluded that fibroblast replication is an important mechanism leading to the pathologic fibrosis seen in graft versus host disease and, by analogy, probably other types of immunologically mediated fibrosis.
(20) The authors followed up the occurrence of inflammation-mediated osteopenia (IMO) in young and adult rats weighing 50 g and 150 g, respectively.
Mediatorial
Definition:
(a.) Of or pertaining to a mediator, or to mediation; mediatory; as, a mediatorial office.
Example Sentences:
(1) The presently available data allow us to draw the following conclusions: 1) G proteins play a mediatory role in the transmission of the signal(s) generated upon receptor occupancy that leads to the observed cytoskeletal changes.
(2) The mediatory role of the central-m-cholinergic systems in the mechanisms of COH and that of n-cholinergic systems in the estrogen-induced suppression of COH is suggested.
(3) In addition, the insulin-like effect on enzyme release induced by the GTP non-hydrolysable analog, GTP-gamma-S, and its sensitivity to the pertussis toxin are in favour of a mediatory role exerted by the G proteins system, in the transduction of some actions of insulin.
(4) It is assumed that norepinephrine is involved in the mediatory system activating goal-directed motivational behaviour, but it does not constitute, as it seems, the major mediator of the reinforcement system.
(5) The data presented demonstrate that AldDG activity is connected with those cerebral structures that are supposed to possess, in the process of common and mediatory metabolism, a high level of natural synthesis of aldehydes.
(6) The liquor levels of enhancement mediatory amino acids, aspartic and glutaminic, rise early in poisoning, while concentration of inhibition mediator glycine tends to decline.
(7) The results of the present study suggest that prostaglandin E2 and CV-3988 may have acted via a similar mechanism, possibly involving inhibition of a mediatory role of platelet-activating factor in endotoxic shock.
(8) Complex combinations of the constant functional load exerted on the organ with the metabolic effects of the mediatory block in the tissues and disorders of their blood supply are the causes of tissue energy deficiency.
(9) It is possible that the structural rearrangements observed in the serotoninergic and in the conjugated to it mediatory systems make the base of functional disorders in the neocortex and are accompanied with certain changes in the integrative activity of the brain.
(10) In cough, on the other hand, they operate concurrently, a mediatory role for RARs and a facilitatory role for SARs.
(11) These results indicate that perifused bovine parathyroid cells respond to secretagogues with a time course comparable to that observed in vivo and that the temporal changes in cytosolic calcium concentration and cellular cAMP are consistent with a mediatory role for these factors in low calcium- and dopamine-stimulated secretion, respectively.
(12) At the same time in subjects of advanced age the reactivity of the mediatory link in systolic hypertension remains intact, this manifesting itself in a significantly increased noradrenaline passage, as compared to a low initial level following administration of insulin.
(13) While these findings do not strengthen the link between exercise and stress response, they demonstrate the significant mediatory roles of habituation and anticipation in laboratory studies employing a test-retest design.
(14) The immediate appearance of the inhibitory effect suggests the mediatory role of the nervous system in this response.
(15) Captopril pretreatment inhibits the aldosterone response, suggesting that the aldosterone stimulatory properties of 5-HTP require the presence of angiotensin II, although it is unclear whether it acts in a mediatory or permissive capacity.
(16) The mediatory stage in development of the pulmonary innervation begins on the 3d month of the human intrauterine development.
(17) IL-6 production by UMR-106 osteogenic osteosarcoma cells was positively modulated by IGF-I, indicating that osteoblasts are likely to be the cells responsible for increased IL-6 production by the bones, and that IL-6 might be a mediatory of IGF-I-stimulated bone resorption.
(18) Some regularities of mediatory function of lipoxygenase systems have been found.
(19) In examination of patients with thyrotoxicosis, aged from 14 to 24 years, there was revealed a reduction of the activity of the mediatory link of the sympathico-adrenal ssystem without any connection with age, the severity and duration of the disease, and also with the efficacy of drug therapy.
(20) All the pharmacological drugs studied could exhibit the mediatory effects on opioid peptides in heart via alterations in activity of vegetative nervous system affecting the myocardium.