(a.) Being between the two extremes; middle; interposed; intervening; intermediate.
(a.) Acting by means, or by an intervening cause or instrument; not direct or immediate; acting or suffering through an intervening agent or condition.
(a.) Gained or effected by a medium or condition.
(a.) To be in the middle, or between two; to intervene.
(a.) To interpose between parties, as the equal friend of each, esp. for the purpose of effecting a reconciliation or agreement; as, to mediate between nations.
(v. t.) To effect by mediation or interposition; to bring about as a mediator, instrument, or means; as, to mediate a peace.
(v. t.) To divide into two equal parts.
Example Sentences:
(1) Stimulation of human leukocytes with various chemical mediators such as TPA, f-Met-Leu-Phe, LTB4, etc.
(2) Fibulin is a potential mediator of interactions between adhesion receptors and the cytoskeleton.
(3) Patients with papillary carcinoma with a good cell-mediated immune response occurred with much lower infiltration of the tumor boundary with lymphocyte whereas the follicular carcinoma less cell-mediated immunity was associated with dense lymphocytic infiltration, suggesting the biological relevance of lymphocytic infiltration may be different for the two histologic variants.
(4) The hypothesis that proteins are critical targets in free radical mediated cytolysis was tested using U937 mononuclear phagocytes as targets and iron together with hydrogen peroxide to generate radicals.
(5) We have investigated the effect of methimazole (MMI) on cell-mediated immunity and ascertained the mechanisms of immunosuppression produced by the drug.
(6) We determined whether serological investigations can assist to distinguish between chronic idiopathic autoimmune thrombocytopenia (cAITP) and immune-mediated thrombocytopenia in patients at risk to develop systemic lupus erythematosus (SLE); 82 patients were seen in this institution for the evaluation of immune thrombocytopenia.
(7) IgE-mediated acute systemic reactions to penicillin continue to be an important clinical problem.
(8) This induction is sensitive to actinomycin D but not to protein synthesis inhibitor puromycin, indicating an effect of estradiol at the transcriptional level, possibly mediated by the estrogen receptor.
(9) We sought additional evidence for an inverse relationship between functional CTL-target cell affinity on the one hand, and susceptibility of the CTL-mediated killing to inhibition by alpha LFA-1 and alpha Lyt-2,3 monoclonal antibodies on the other hand.
(10) Mannose receptor mediated uptake by the reticuloendothelial system has been suggested as an explanation for the rapid removal of ricin A chain antibody conjugates from the circulation after their administration.
(11) However, direct measurements of mediator release should be carried out to reach a firm conclusion.
(12) In addition to their involvement in thrombosis, activated platelets release growth factors, most notably a platelet-derived growth factor (PDGF) which may be the principal mediator of smooth muscle cell migration from the media into the intima and of smooth muscle cell proliferation in the intima as well as of vasoconstriction.
(13) Glutathion peroxidase and p-phenylenediamide-mediated peroxidase (PPD-peroxidase) were normal in leucocytes of 1 HPS patient.
(14) But MH162 was more effective than MRK16 in lymphocyte-mediated lysis of the MDR cells.
(15) Thus, human bronchial epithelial cells can express the IL-8 gene, with expression in response to the inflammatory mediator TNF regulated mainly at the transcriptional level, and with elements within the 5'-flanking region of the gene that are directly or indirectly modulated by the TNF signal.
(16) Tumour necrosis factor (TNF), a polypeptide produced by mononuclear phagocytes, has been implicated as an important mediator of inflammatory processes and of clinical manifestations in acute infectious diseases.
(17) From these results, it was suggested that the inhibitory effect of Cd on in vitro calcification of MC3T3-E1 cells may be due to both a depression of cell-mediated calcification and a decrease in physiochemical mineral deposition.
(18) injection of various inflammatory mediators, the vasopressor effect of i.a.
(19) It is concluded that fibroblast replication is an important mechanism leading to the pathologic fibrosis seen in graft versus host disease and, by analogy, probably other types of immunologically mediated fibrosis.
(20) The authors followed up the occurrence of inflammation-mediated osteopenia (IMO) in young and adult rats weighing 50 g and 150 g, respectively.
Mitigate
Definition:
(v. t.) To make less severe, intense, harsh, rigorous, painful, etc.; to soften; to meliorate; to alleviate; to diminish; to lessen; as, to mitigate heat or cold; to mitigate grief.
(v. t.) To make mild and accessible; to mollify; -- applied to persons.
Example Sentences:
(1) In mitigation, Gareth Jones, defending, said: "The first comment [he] wrote was in relation to Fabrice Muamba.
(2) The small numbers involved (29) and the difficulties in matching subjects may have mitigated against demonstrating a statistically significant difference between the two groups.
(3) The news comes one week after Marshall announced, in an email to staff, that there would be a shift in research priorities, away from understanding the nature of climate change, and towards adaptation and mitigation.
(4) Golding said the government would not soften its stance on drug trafficking and it intended to use a proportion of revenues from its licensing authority to support a public education campaign to discourage pot-smoking by young people and mitigate public health consequences.
(5) This has improved the capacity of the neuroanaesthetist to mitigate the inevitable fluctuations which occur and prevent their ill effects.
(6) The survey was designed to assess whether these individuals followed the 1986 EPA guidelines for follow-up testing and mitigation.
(7) Despite doing a study of mitigation options, no decisions are planned until 2012.
(8) The level of disruption to services will vary widely and depend on the number of staff joining the strike, the mitigating impact of the NHS’s contingency planning and how many patients need acute care, such as A&E care or surgery.
(9) Aid workers have warned that children in the disaster zone left by typhoon Haiyan are particularly vulnerable, as they set up child-focused services to mitigate the impact.
(10) Regression analyses suggested that such aggression-inhibitory effects of an apology were mediated by impression improvement, emotional mitigation, and reduction in desire for an apology within the victims.
(11) At present, however, technical and economic factors combine to mitigate against MRI.
(12) The IPCC is charged with providing a scientific, balanced assessment about what's known and what's known about climate change There are lots of organisations ringing bells The IPCC is more like a belltower, which people can climb up to get a clear view 8.41am BST Al Gore , the former US vice-president and winner of the Nobel peace prize for his work on climate change , has responded to the IPCC report by saying it shows the need for a switch to low carbon sources of energy (note his emphasis is on mitigation, i.e.
(13) Potential strategies to avoid the precipitating antigen antibody reaction or to mitigate the resulting effector cascade are described.
(14) The results of this study serve to mitigate concern over the possible carcinogenicity of MDA in the diet, since less than 10% of the MDA in several foods containing highly unsaturated fatty acids was found in the free form.
(15) The deputy president, William Ruto, said it is now up to the developed world to mitigate the fallout, suggesting that other countries including the UK should resettle the refugees who could soon be kicked out of Kenya.
(16) Application of the formula in 3 patients with the juvenile CLF, the M. Batten-Spielmeyer-Vogt, resulted in a mitigated course of the disease.
(17) "The one thing that we have come up with is the importance of adaptation and mitigation choices.
(18) There is an art as well as a science to accurately presenting devastating facts while mitigating potentially unnecessary emotional damage.
(19) The issue is the capacity of the law to mitigate it.
(20) Delivery of oxygenated autologous blood to the myocardium at risk during inflation may help mitigate this ischemia.