(a.) Being between the two extremes; middle; interposed; intervening; intermediate.
(a.) Acting by means, or by an intervening cause or instrument; not direct or immediate; acting or suffering through an intervening agent or condition.
(a.) Gained or effected by a medium or condition.
(a.) To be in the middle, or between two; to intervene.
(a.) To interpose between parties, as the equal friend of each, esp. for the purpose of effecting a reconciliation or agreement; as, to mediate between nations.
(v. t.) To effect by mediation or interposition; to bring about as a mediator, instrument, or means; as, to mediate a peace.
(v. t.) To divide into two equal parts.
Example Sentences:
(1) Stimulation of human leukocytes with various chemical mediators such as TPA, f-Met-Leu-Phe, LTB4, etc.
(2) Fibulin is a potential mediator of interactions between adhesion receptors and the cytoskeleton.
(3) Patients with papillary carcinoma with a good cell-mediated immune response occurred with much lower infiltration of the tumor boundary with lymphocyte whereas the follicular carcinoma less cell-mediated immunity was associated with dense lymphocytic infiltration, suggesting the biological relevance of lymphocytic infiltration may be different for the two histologic variants.
(4) The hypothesis that proteins are critical targets in free radical mediated cytolysis was tested using U937 mononuclear phagocytes as targets and iron together with hydrogen peroxide to generate radicals.
(5) We have investigated the effect of methimazole (MMI) on cell-mediated immunity and ascertained the mechanisms of immunosuppression produced by the drug.
(6) We determined whether serological investigations can assist to distinguish between chronic idiopathic autoimmune thrombocytopenia (cAITP) and immune-mediated thrombocytopenia in patients at risk to develop systemic lupus erythematosus (SLE); 82 patients were seen in this institution for the evaluation of immune thrombocytopenia.
(7) IgE-mediated acute systemic reactions to penicillin continue to be an important clinical problem.
(8) This induction is sensitive to actinomycin D but not to protein synthesis inhibitor puromycin, indicating an effect of estradiol at the transcriptional level, possibly mediated by the estrogen receptor.
(9) We sought additional evidence for an inverse relationship between functional CTL-target cell affinity on the one hand, and susceptibility of the CTL-mediated killing to inhibition by alpha LFA-1 and alpha Lyt-2,3 monoclonal antibodies on the other hand.
(10) Mannose receptor mediated uptake by the reticuloendothelial system has been suggested as an explanation for the rapid removal of ricin A chain antibody conjugates from the circulation after their administration.
(11) However, direct measurements of mediator release should be carried out to reach a firm conclusion.
(12) In addition to their involvement in thrombosis, activated platelets release growth factors, most notably a platelet-derived growth factor (PDGF) which may be the principal mediator of smooth muscle cell migration from the media into the intima and of smooth muscle cell proliferation in the intima as well as of vasoconstriction.
(13) Glutathion peroxidase and p-phenylenediamide-mediated peroxidase (PPD-peroxidase) were normal in leucocytes of 1 HPS patient.
(14) But MH162 was more effective than MRK16 in lymphocyte-mediated lysis of the MDR cells.
(15) Thus, human bronchial epithelial cells can express the IL-8 gene, with expression in response to the inflammatory mediator TNF regulated mainly at the transcriptional level, and with elements within the 5'-flanking region of the gene that are directly or indirectly modulated by the TNF signal.
(16) Tumour necrosis factor (TNF), a polypeptide produced by mononuclear phagocytes, has been implicated as an important mediator of inflammatory processes and of clinical manifestations in acute infectious diseases.
(17) From these results, it was suggested that the inhibitory effect of Cd on in vitro calcification of MC3T3-E1 cells may be due to both a depression of cell-mediated calcification and a decrease in physiochemical mineral deposition.
(18) injection of various inflammatory mediators, the vasopressor effect of i.a.
(19) It is concluded that fibroblast replication is an important mechanism leading to the pathologic fibrosis seen in graft versus host disease and, by analogy, probably other types of immunologically mediated fibrosis.
(20) The authors followed up the occurrence of inflammation-mediated osteopenia (IMO) in young and adult rats weighing 50 g and 150 g, respectively.
Mollify
Definition:
(v. t.) To soften; to make tender; to reduce the hardness, harshness, or asperity of; to qualify; as, to mollify the ground.
(v. t.) To assuage, as pain or irritation, to appease, as excited feeling or passion; to pacify; to calm.
Example Sentences:
(1) "On the contrary, they often serve to inflame rather than mollify the feelings of those involved."
(2) The government has promised to pay for the treatment costs of the victims, but parents are unlikely to be easily mollified.
(3) Randomized studies, attempting to clarify the role of combined azathioprine and prednisone therapy versus prednisone alone in severe systemic lupus erythematosus have sustained rather than mollified a clinical controversy.
(4) All the evidence is that, in Scotland at least, had Corbyn been in charge at the time of the election, even the time of last year’s referendum, Labour’s meltdown may have been substantially mollified.
(5) The Department for Transport unveiled several tweaks to the first stage of the HS2 route to mollify opponents in the wealthy commuter belt north and west of London.
(6) The city's Communist Party chief Tang Jun and mayor Li Wancai attempted to mollify the crowd with a promise to move the polluting project out of the city," according to the Xinhua news agency.
(7) The next time you hear mollifying words from Rudd that our rising debt levels are at reasonable levels compared to other countries, think about how Britons were lulled into the financial danger zone and ask yourself: are we on the same trajectory?
(8) What is now known, thanks to the Leveson process, is that James Murdoch was considerably mollified at the time.
(9) In a bid to mollify critics, Obama said: "We will never undertake this research lightly.
(10) This seems like a statement designed simply to mollify concerned backbenchers but lacking the substance to actually protect the countryside from fracking pollution.” Martin Harper, RSPB’s conservation director, said: “We are very pleased the government has indicated it intends to ban fracking in England’s best places for wildlife, Sites of Special Scientific Interest.
(11) On the contrary they often serve to inflame rather than mollify the feelings of those involved."
(12) He thinks, too, that Downing Street's recent concerns over the children's services agenda - its perceived lack of measurable outcomes and its feared drag on academic attainment - have been mollified.
(13) I hope you understand.” Supporters – overwhelmingly pro-Federer, as usual – were mollified to an extent that Andy Murray , who suffered an overwhelming defeat by Federer in the final qualifying match, would step in to play a “pro set” of first to eight games against Djokovic, as well as a doubles match, partnering John McEnroe against Tim Henman and Pat Cash.
(14) But, apparently mollified by Gove's comments, Wilshaw put out a fresh statement on Sunday night, saying: "I have talked to the secretary of state today and I know that he is 100% supportive of my leadership.
(15) His reasons were the sheer scale of emissions from China’s coal-fuelled factories, and a need to mollify American public opinion.
(16) The speech appeared to be an attempt to rally his Islamist support base, with little to mollify the millions who marched for his removal in July.
(17) The investigations into Mubarak's sons are expected to mollify the opposition.
(18) Corbyn faces tension between assuring supporters that the policy direction will change and the need to mollify some frontbenchers who regard international issues, such as the UK-US relationship, as a principle they cannot compromise on.
(19) Nor were they mollified by his refusal to underwrite their future should any of them be convicted.
(20) His appointment could mollify Independent journalists worried that the potential appointment of Liddle could overturn the paper's liberal values.