(a.) Being between the two extremes; middle; interposed; intervening; intermediate.
(a.) Acting by means, or by an intervening cause or instrument; not direct or immediate; acting or suffering through an intervening agent or condition.
(a.) Gained or effected by a medium or condition.
(a.) To be in the middle, or between two; to intervene.
(a.) To interpose between parties, as the equal friend of each, esp. for the purpose of effecting a reconciliation or agreement; as, to mediate between nations.
(v. t.) To effect by mediation or interposition; to bring about as a mediator, instrument, or means; as, to mediate a peace.
(v. t.) To divide into two equal parts.
Example Sentences:
(1) Stimulation of human leukocytes with various chemical mediators such as TPA, f-Met-Leu-Phe, LTB4, etc.
(2) Fibulin is a potential mediator of interactions between adhesion receptors and the cytoskeleton.
(3) Patients with papillary carcinoma with a good cell-mediated immune response occurred with much lower infiltration of the tumor boundary with lymphocyte whereas the follicular carcinoma less cell-mediated immunity was associated with dense lymphocytic infiltration, suggesting the biological relevance of lymphocytic infiltration may be different for the two histologic variants.
(4) The hypothesis that proteins are critical targets in free radical mediated cytolysis was tested using U937 mononuclear phagocytes as targets and iron together with hydrogen peroxide to generate radicals.
(5) We have investigated the effect of methimazole (MMI) on cell-mediated immunity and ascertained the mechanisms of immunosuppression produced by the drug.
(6) We determined whether serological investigations can assist to distinguish between chronic idiopathic autoimmune thrombocytopenia (cAITP) and immune-mediated thrombocytopenia in patients at risk to develop systemic lupus erythematosus (SLE); 82 patients were seen in this institution for the evaluation of immune thrombocytopenia.
(7) IgE-mediated acute systemic reactions to penicillin continue to be an important clinical problem.
(8) This induction is sensitive to actinomycin D but not to protein synthesis inhibitor puromycin, indicating an effect of estradiol at the transcriptional level, possibly mediated by the estrogen receptor.
(9) We sought additional evidence for an inverse relationship between functional CTL-target cell affinity on the one hand, and susceptibility of the CTL-mediated killing to inhibition by alpha LFA-1 and alpha Lyt-2,3 monoclonal antibodies on the other hand.
(10) Mannose receptor mediated uptake by the reticuloendothelial system has been suggested as an explanation for the rapid removal of ricin A chain antibody conjugates from the circulation after their administration.
(11) However, direct measurements of mediator release should be carried out to reach a firm conclusion.
(12) In addition to their involvement in thrombosis, activated platelets release growth factors, most notably a platelet-derived growth factor (PDGF) which may be the principal mediator of smooth muscle cell migration from the media into the intima and of smooth muscle cell proliferation in the intima as well as of vasoconstriction.
(13) Glutathion peroxidase and p-phenylenediamide-mediated peroxidase (PPD-peroxidase) were normal in leucocytes of 1 HPS patient.
(14) But MH162 was more effective than MRK16 in lymphocyte-mediated lysis of the MDR cells.
(15) Thus, human bronchial epithelial cells can express the IL-8 gene, with expression in response to the inflammatory mediator TNF regulated mainly at the transcriptional level, and with elements within the 5'-flanking region of the gene that are directly or indirectly modulated by the TNF signal.
(16) Tumour necrosis factor (TNF), a polypeptide produced by mononuclear phagocytes, has been implicated as an important mediator of inflammatory processes and of clinical manifestations in acute infectious diseases.
(17) From these results, it was suggested that the inhibitory effect of Cd on in vitro calcification of MC3T3-E1 cells may be due to both a depression of cell-mediated calcification and a decrease in physiochemical mineral deposition.
(18) injection of various inflammatory mediators, the vasopressor effect of i.a.
(19) It is concluded that fibroblast replication is an important mechanism leading to the pathologic fibrosis seen in graft versus host disease and, by analogy, probably other types of immunologically mediated fibrosis.
(20) The authors followed up the occurrence of inflammation-mediated osteopenia (IMO) in young and adult rats weighing 50 g and 150 g, respectively.
Settlement
Definition:
(n.) The act of setting, or the state of being settled.
(n.) Establishment in life, in business, condition, etc.; ordination or installation as pastor.
(n.) The act of peopling, or state of being peopled; act of planting, as a colony; colonization; occupation by settlers; as, the settlement of a new country.
(n.) The act or process of adjusting or determining; composure of doubts or differences; pacification; liquidation of accounts; arrangement; adjustment; as, settlement of a controversy, of accounts, etc.
(n.) Bestowal, or giving possession, under legal sanction; the act of giving or conferring anything in a formal and permanent manner.
(n.) A disposition of property for the benefit of some person or persons, usually through the medium of trustees, and for the benefit of a wife, children, or other relatives; jointure granted to a wife, or the act of granting it.
(n.) That which settles, or is settled, established, or fixed.
(n.) Matter that subsides; settlings; sediment; lees; dregs.
(n.) A colony newly established; a place or region newly settled; as, settlement in the West.
(n.) That which is bestowed formally and permanently; the sum secured to a person; especially, a jointure made to a woman at her marriage; also, in the United States, a sum of money or other property formerly granted to a pastor in additional to his salary.
(n.) The gradual sinking of a building, whether by the yielding of the ground under the foundation, or by the compression of the joints or the material.
(n.) Fractures or dislocations caused by settlement.
(n.) A settled place of abode; residence; a right growing out of residence; legal residence or establishment of a person in a particular parish or town, which entitles him to maintenance if a pauper, and subjects the parish or town to his support.
Example Sentences:
(1) JPMorgan did not reveal the terms of the settlement.
(2) As long as Israel refuses to cease settlement activities and to the release of the fourth group of Palestinian prisoners in accordance with our agreements, they leave us no choice but to insist that we will not remain the only ones committed to the implementation of these agreements, while Israel continuously violates them,” Abbas said.
(3) "We will respect the principle of multi-year [funding] settlements," Hunt told a Voice of the Listener and Viewer conference in London.
(4) During evidence in chief, he said the only people who would amend a settlement or information about a trade would be "the person who knew of the transaction, who would be the trader."
(5) In a 2011 interview with the Financial Times he said: “JPMorgan doesn’t have a chance in hell of not coming up with a big settlement.” He claimed: “There were people at the bank who knew what was going on.” The payment brings the total of fines imposed on JP Morgan to nearly $20bn in the past year.
(6) Gerson Zweifach, general counsel for both News Corp and 21st Century Fox , Murdoch’s film and TV business, said: “We are grateful that this matter has been concluded and acknowledge the fairness and professionalism of the Department of Justice throughout this investigation.” It is understood there has been no background settlement with the Department of Justice in order to avoid a full-blown investigation, contrary to speculation in New York over a year ago that the company was looking at a possible payment of over $850m.
(7) The filings do not contain any clues about the size of the settlement that the DoJ was hoping to reach with Barclays, although the bank is thought to have been prepared to pay up to $2bn (£1.6bn).
(8) The announcement comes amid mounting frustration in the international community over Israel’s continued settlement activity, regarded by many countries as illegal.
(9) Obama will meet with Binyamin Netanyahu and Mahmoud Abbas tomorrow as well, but US envoy George Mitchell has had no luck in recent weeks trying to persuade Netanyahu to compromise on the settlements.
(10) The environment is going to pay a high price for its settlement in the recent spending review."
(11) In the Commons on Monday , John Whittingdale, the culture secretary who only in February chaired the committee that concluded “No future licence fee negotiations must be conducted in the way of the 2010 settlement”, ducked the invitation to explain how exactly the same thing had just happened again.
(12) An additional 200,000 Jews live in settlements in East Jerusalem.
(13) "The priorities are public order, improved lives for the people of Libya and an inclusive, peaceful settlement led by the Libyan people."
(14) Further south is Ghadames, one of the most ancient settlements in north Africa , which Unesco calls “the pearl of the desert”.
(15) HIV-1 infection was 1.5 times more common in women than in men; 2.5% of the adult population in rural villages, 7.3% in roadside settlements and 11.8% in town were infected.
(16) In American football, however, more than 4,500 former NFL players sued their league for downplaying the dangers of concussion, and last year there was an out-of-court settlement for around £500m.
(17) Israel's illegal settlements are so entrenched that uprooting them to make way for a viable Palestinian state has become impossible.
(18) In fact, CFAs generally involve payment of a "success fee" on top of normal legal fees; the payment is not calculated as a proportion of the final settlement.
(19) They belong to the people who built Choquequirao, one of the most remote Inca settlements in the Andes, and were stashed here by the archaeologists who, over the past 20 years, have been slowly freeing the ruins from the cloud forest.
(20) In 2004, the dispute settlement body , the "judicial branch" of the WTO, ruled that the US had to reform its cotton subsidies or face "retaliation" from Brazil.