(a.) The act of mediating; action or relation of anything interposed; action as a necessary condition, means, or instrument; interposition; intervention.
(a.) Hence, specifically, agency between parties at variance, with a view to reconcile them; entreaty for another; intercession.
Example Sentences:
(1) Stimulation of human leukocytes with various chemical mediators such as TPA, f-Met-Leu-Phe, LTB4, etc.
(2) Fibulin is a potential mediator of interactions between adhesion receptors and the cytoskeleton.
(3) Patients with papillary carcinoma with a good cell-mediated immune response occurred with much lower infiltration of the tumor boundary with lymphocyte whereas the follicular carcinoma less cell-mediated immunity was associated with dense lymphocytic infiltration, suggesting the biological relevance of lymphocytic infiltration may be different for the two histologic variants.
(4) The hypothesis that proteins are critical targets in free radical mediated cytolysis was tested using U937 mononuclear phagocytes as targets and iron together with hydrogen peroxide to generate radicals.
(5) We have investigated the effect of methimazole (MMI) on cell-mediated immunity and ascertained the mechanisms of immunosuppression produced by the drug.
(6) We determined whether serological investigations can assist to distinguish between chronic idiopathic autoimmune thrombocytopenia (cAITP) and immune-mediated thrombocytopenia in patients at risk to develop systemic lupus erythematosus (SLE); 82 patients were seen in this institution for the evaluation of immune thrombocytopenia.
(7) IgE-mediated acute systemic reactions to penicillin continue to be an important clinical problem.
(8) This induction is sensitive to actinomycin D but not to protein synthesis inhibitor puromycin, indicating an effect of estradiol at the transcriptional level, possibly mediated by the estrogen receptor.
(9) We sought additional evidence for an inverse relationship between functional CTL-target cell affinity on the one hand, and susceptibility of the CTL-mediated killing to inhibition by alpha LFA-1 and alpha Lyt-2,3 monoclonal antibodies on the other hand.
(10) Mannose receptor mediated uptake by the reticuloendothelial system has been suggested as an explanation for the rapid removal of ricin A chain antibody conjugates from the circulation after their administration.
(11) However, direct measurements of mediator release should be carried out to reach a firm conclusion.
(12) In addition to their involvement in thrombosis, activated platelets release growth factors, most notably a platelet-derived growth factor (PDGF) which may be the principal mediator of smooth muscle cell migration from the media into the intima and of smooth muscle cell proliferation in the intima as well as of vasoconstriction.
(13) Glutathion peroxidase and p-phenylenediamide-mediated peroxidase (PPD-peroxidase) were normal in leucocytes of 1 HPS patient.
(14) But MH162 was more effective than MRK16 in lymphocyte-mediated lysis of the MDR cells.
(15) Thus, human bronchial epithelial cells can express the IL-8 gene, with expression in response to the inflammatory mediator TNF regulated mainly at the transcriptional level, and with elements within the 5'-flanking region of the gene that are directly or indirectly modulated by the TNF signal.
(16) Tumour necrosis factor (TNF), a polypeptide produced by mononuclear phagocytes, has been implicated as an important mediator of inflammatory processes and of clinical manifestations in acute infectious diseases.
(17) From these results, it was suggested that the inhibitory effect of Cd on in vitro calcification of MC3T3-E1 cells may be due to both a depression of cell-mediated calcification and a decrease in physiochemical mineral deposition.
(18) injection of various inflammatory mediators, the vasopressor effect of i.a.
(19) It is concluded that fibroblast replication is an important mechanism leading to the pathologic fibrosis seen in graft versus host disease and, by analogy, probably other types of immunologically mediated fibrosis.
(20) The authors followed up the occurrence of inflammation-mediated osteopenia (IMO) in young and adult rats weighing 50 g and 150 g, respectively.
Mediocre
Definition:
(a.) Of a middle quality; of but a moderate or low degree of excellence; indifferent; ordinary.
(n.) A mediocre person.
(n.) A young monk who was excused from performing a portion of a monk's duties.
Example Sentences:
(1) The interobserver variability of these indices is low (r greater than 0.96); reproducibility is good in patients with sinus rhythm but mediocre in atrial fibrillation.
(2) Only a few weeks ago he described English education as “mediocre”.
(3) This is a community where readers' patience for mediocrity is measured in seconds not minutes," added Thomson, the former Times editor who moved to New York to run the WSJ at the end of 2007 following Rupert Murdoch's acquisition of the paper's publisher, Dow Jones.
(4) The hospital laboratory was asked to provide for diffractometric analysis samples of the "mediocre" semens of quality similar enough to the "control" ones what concerns the percentage of motile spermatozoa (40 percent) and spermatozoan concentration.
(5) The unprecedented stimuli provided by central banks has kept activity ticking over, but proved unable to lift the global economy out of what Lagarde calls “the new mediocre”.
(6) I'm sure that advisers are at fault: mediocre people with PR degrees, eagerly advising on how to avoid the resentment of the masses.
(7) The value of conventional non-invasive methods is limited by a high failure rate (standard echocardiography in patients with chronic respiratory disease), a mediocre sensitivity, notably in detecting moderate PAH (electrocardiography, radiography of the chest, myocardial thalium scintigraphy) or a poor specificity (isotopic angiography).
(8) From the endocrine point of view, the mediocre prognosis is aggravated by high energy radiotherapy.
(9) The mediocre results among the group of inoperable patients suggest that other chemotherapy protocols need to be tested.
(10) This grid, used for the analysis of 527 randomized trials, showed that about one-half of them were of mediocre quality, the most frequent defects encountered being the multiplicity of assessment criteria, the lack of description of the subjects excluded, the absence of calculation of the number of subjects required before starting the trial and the small number of subjects in trials with non-significant results.
(11) Negative and mediocre results were more frequent in cases of gonarthrosis.
(12) Its contribution is obviously essential when, for technical reasons, arterial opacification is only mediocre (extended angiocardiopneumography).
(13) Stock Woolstencroft , architects of the dismal Stratford towers, are attempting to continue their march of mediocrity with schemes on the other side of the park.
(14) All the interviews supported the notion of an arbitrary norm for pay, which almost all firms felt was grossly and inappropriately high … The general view of search firms is that a lower norm would not materially affect what happens.” One headhunter said: “I think there are an awful lot of FTSE 100 CEOs who are pretty mediocre.” Another added: “I think that the wage drift over the past 10 years, or the salary drift, has been inexcusable, incomprehensible, and it is very serious for the social fabric of the country.” The findings are being made public just as an analysis by the High Pay Centre thinktank shows that the average pay of a chief executive – including pensions, share options and bonuses – stands at about £4.6m.
(15) A mediocre succession of atria and galleries, it does at least give artists space.
(16) Such has been the generally mediocre standard of Woods' play over the last two years, he has had perhaps only half a dozen realistic chances of winning on Sunday afternoon.
(17) This would happen especially if the school inspectorate Ofsted found they were failing, mediocre, fragile or coasting.
(18) For the svengali of mediocrity decreed that every year would culminate in the release of a single from the winner of his X Factor, and that this contribution to the lexicon would dutifully top the charts.
(19) Chemicals on the loop were Ca (abundant); Mg (marked); Si (mediocre); Ab, Ba, Fe (insignificant); Mn, Mo, Zn, P (trace).
(20) While the Lakers' two-year contract extension may end up being "an expensive mediocrity overpaying a franchise star in decline", as Grantland's Zach Lowe has put it , it could also have very well been the only move it could have sold to its fans.