(n.) One who mediates; especially, one who interposes between parties at variance for the purpose of reconciling them; hence, an intercessor.
Example Sentences:
(1) Stimulation of human leukocytes with various chemical mediators such as TPA, f-Met-Leu-Phe, LTB4, etc.
(2) Fibulin is a potential mediator of interactions between adhesion receptors and the cytoskeleton.
(3) Patients with papillary carcinoma with a good cell-mediated immune response occurred with much lower infiltration of the tumor boundary with lymphocyte whereas the follicular carcinoma less cell-mediated immunity was associated with dense lymphocytic infiltration, suggesting the biological relevance of lymphocytic infiltration may be different for the two histologic variants.
(4) The hypothesis that proteins are critical targets in free radical mediated cytolysis was tested using U937 mononuclear phagocytes as targets and iron together with hydrogen peroxide to generate radicals.
(5) We have investigated the effect of methimazole (MMI) on cell-mediated immunity and ascertained the mechanisms of immunosuppression produced by the drug.
(6) We determined whether serological investigations can assist to distinguish between chronic idiopathic autoimmune thrombocytopenia (cAITP) and immune-mediated thrombocytopenia in patients at risk to develop systemic lupus erythematosus (SLE); 82 patients were seen in this institution for the evaluation of immune thrombocytopenia.
(7) IgE-mediated acute systemic reactions to penicillin continue to be an important clinical problem.
(8) This induction is sensitive to actinomycin D but not to protein synthesis inhibitor puromycin, indicating an effect of estradiol at the transcriptional level, possibly mediated by the estrogen receptor.
(9) We sought additional evidence for an inverse relationship between functional CTL-target cell affinity on the one hand, and susceptibility of the CTL-mediated killing to inhibition by alpha LFA-1 and alpha Lyt-2,3 monoclonal antibodies on the other hand.
(10) Mannose receptor mediated uptake by the reticuloendothelial system has been suggested as an explanation for the rapid removal of ricin A chain antibody conjugates from the circulation after their administration.
(11) However, direct measurements of mediator release should be carried out to reach a firm conclusion.
(12) In addition to their involvement in thrombosis, activated platelets release growth factors, most notably a platelet-derived growth factor (PDGF) which may be the principal mediator of smooth muscle cell migration from the media into the intima and of smooth muscle cell proliferation in the intima as well as of vasoconstriction.
(13) Glutathion peroxidase and p-phenylenediamide-mediated peroxidase (PPD-peroxidase) were normal in leucocytes of 1 HPS patient.
(14) But MH162 was more effective than MRK16 in lymphocyte-mediated lysis of the MDR cells.
(15) Thus, human bronchial epithelial cells can express the IL-8 gene, with expression in response to the inflammatory mediator TNF regulated mainly at the transcriptional level, and with elements within the 5'-flanking region of the gene that are directly or indirectly modulated by the TNF signal.
(16) Tumour necrosis factor (TNF), a polypeptide produced by mononuclear phagocytes, has been implicated as an important mediator of inflammatory processes and of clinical manifestations in acute infectious diseases.
(17) From these results, it was suggested that the inhibitory effect of Cd on in vitro calcification of MC3T3-E1 cells may be due to both a depression of cell-mediated calcification and a decrease in physiochemical mineral deposition.
(18) injection of various inflammatory mediators, the vasopressor effect of i.a.
(19) It is concluded that fibroblast replication is an important mechanism leading to the pathologic fibrosis seen in graft versus host disease and, by analogy, probably other types of immunologically mediated fibrosis.
(20) The authors followed up the occurrence of inflammation-mediated osteopenia (IMO) in young and adult rats weighing 50 g and 150 g, respectively.
Middleman
Definition:
(n.) An agent between two parties; a broker; a go-between; any dealer between the producer and the consumer; in Ireland, one who takes land of the proprietors in large tracts, and then rents it out in small portions to the peasantry.
(n.) A person of intermediate rank; a commoner.
(n.) The man who occupies a central position in a file of soldiers.
Example Sentences:
(1) That’s an open debate.” Some on the cities’ side want the department for communities and local government abolished, seeing it as an obstructive middleman, while their Charter for Local Freedom calls for an independent body to oversee the transfer of powers.
(2) Culture secretary Sajid Javid has said that ticket touts are “classic entrepreneurs” and their detractors are the “chattering middle classes and champagne socialists, who have no interest in helping the common working man earn a decent living by acting as a middleman”.
(3) It is time to cut out the middleman, releasing the money that is presently being wasted and transferring control of employment support to those who know how it can be used best – disabled people and employers."
(4) But coyote is also used to denote a middleman, particularly one who takes advantage of unwitting farmers.
(5) Thom Yorke called the company "the last desperate fart of a dying corpse" in 2013, telling his peers that "I feel like as musicians we need to fight the Spotify thing", suggesting that the company is just another (unwanted) middleman in the music industry.
(6) Syrian-born middleman Wafic Said handled multimillion pound commissions on the deal.
(7) Yesterday's admissions by the Tanzanian middleman, Sailesh Vithlani, led Ms Short to call for BAE's prosecution if the allegations were proved.
(8) The court heard how BAE had hired the Tanzanian middleman, Sailesh Vithlani, to secure the radar contract and gave him $12.4m (£8m) over five years – a third of the contract's value.
(9) In one long-running battle against a rich banker, who sued them over the fit and layout of his £12m One Hyde Park apartment, it was revealed they hired a private detective to pose as a middleman for the Saudi royal family to dig for dirt on their own customer.
(10) As such he is considered a possible middleman between the British government and the Trump administration.
(11) Alibaba, which has its headquarters in the eastern Chinese city of Hangzhou, does not sell products directly but acts as an electronic middleman.
(12) Italian prosecutors claim that the deal to supply the Indian air force with 12 AW101 helicopters - so-called VVIP models used to fly heads of state - involved kickbacks and the use of a British middleman, Christian Michel.
(13) The middlemen then mix the bags together to sell to smelters and companies such as Timah, or "whoever's offering the higher price", says Fitriyadi, 39, a middleman who operates from his home in south Bangka.
(14) But finding a suitable middleman is no easy task, with the Obama administration immersed in bigger global crises and doggedly pursuing a policy of “strategic patience” with the North, which essentially means not getting drawn into engagements that might be seen as bowing to North Korean pressure.
(15) The piece was highly critical of the methods used in previous stings by Mazher Mahmood – the so-called "Fake Sheikh" behind the sensational News of the World claim that a middleman accepted £150,000 to correctly predict the exact time when no-balls would be bowled.
(16) Someone has to absorb the hit, be it the brand, supplier, middleman, retailer or consumer.
(17) He began trading on this connection to the Saudi royal family and was soon pulling in commissions of hundreds of millions of dollars a year acting as a middleman for American companies such as Lockheed, Northrop, Raytheon and Boeing.
(18) He paid a middleman two years ago to smuggle him across the border into Thailand and find him a job in a factory.
(19) The porn turned out to be easy to repel: because they contained affiliate links (where a middleman was getting paid for each clickthrough and signup), "Trust & Safety" assigned someone to contact the porn sites, getting affiliates' accounts cancelled for bad behaviour.
(20) A captain is primarily an off-the-field middleman between the team and the manager, and at times the media.