(n.) One who mediates; especially, one who interposes between parties at variance for the purpose of reconciling them; hence, an intercessor.
Example Sentences:
(1) Stimulation of human leukocytes with various chemical mediators such as TPA, f-Met-Leu-Phe, LTB4, etc.
(2) Fibulin is a potential mediator of interactions between adhesion receptors and the cytoskeleton.
(3) Patients with papillary carcinoma with a good cell-mediated immune response occurred with much lower infiltration of the tumor boundary with lymphocyte whereas the follicular carcinoma less cell-mediated immunity was associated with dense lymphocytic infiltration, suggesting the biological relevance of lymphocytic infiltration may be different for the two histologic variants.
(4) The hypothesis that proteins are critical targets in free radical mediated cytolysis was tested using U937 mononuclear phagocytes as targets and iron together with hydrogen peroxide to generate radicals.
(5) We have investigated the effect of methimazole (MMI) on cell-mediated immunity and ascertained the mechanisms of immunosuppression produced by the drug.
(6) We determined whether serological investigations can assist to distinguish between chronic idiopathic autoimmune thrombocytopenia (cAITP) and immune-mediated thrombocytopenia in patients at risk to develop systemic lupus erythematosus (SLE); 82 patients were seen in this institution for the evaluation of immune thrombocytopenia.
(7) IgE-mediated acute systemic reactions to penicillin continue to be an important clinical problem.
(8) This induction is sensitive to actinomycin D but not to protein synthesis inhibitor puromycin, indicating an effect of estradiol at the transcriptional level, possibly mediated by the estrogen receptor.
(9) We sought additional evidence for an inverse relationship between functional CTL-target cell affinity on the one hand, and susceptibility of the CTL-mediated killing to inhibition by alpha LFA-1 and alpha Lyt-2,3 monoclonal antibodies on the other hand.
(10) Mannose receptor mediated uptake by the reticuloendothelial system has been suggested as an explanation for the rapid removal of ricin A chain antibody conjugates from the circulation after their administration.
(11) However, direct measurements of mediator release should be carried out to reach a firm conclusion.
(12) In addition to their involvement in thrombosis, activated platelets release growth factors, most notably a platelet-derived growth factor (PDGF) which may be the principal mediator of smooth muscle cell migration from the media into the intima and of smooth muscle cell proliferation in the intima as well as of vasoconstriction.
(13) Glutathion peroxidase and p-phenylenediamide-mediated peroxidase (PPD-peroxidase) were normal in leucocytes of 1 HPS patient.
(14) But MH162 was more effective than MRK16 in lymphocyte-mediated lysis of the MDR cells.
(15) Thus, human bronchial epithelial cells can express the IL-8 gene, with expression in response to the inflammatory mediator TNF regulated mainly at the transcriptional level, and with elements within the 5'-flanking region of the gene that are directly or indirectly modulated by the TNF signal.
(16) Tumour necrosis factor (TNF), a polypeptide produced by mononuclear phagocytes, has been implicated as an important mediator of inflammatory processes and of clinical manifestations in acute infectious diseases.
(17) From these results, it was suggested that the inhibitory effect of Cd on in vitro calcification of MC3T3-E1 cells may be due to both a depression of cell-mediated calcification and a decrease in physiochemical mineral deposition.
(18) injection of various inflammatory mediators, the vasopressor effect of i.a.
(19) It is concluded that fibroblast replication is an important mechanism leading to the pathologic fibrosis seen in graft versus host disease and, by analogy, probably other types of immunologically mediated fibrosis.
(20) The authors followed up the occurrence of inflammation-mediated osteopenia (IMO) in young and adult rats weighing 50 g and 150 g, respectively.
Unifier
Definition:
(n.) One who, or that which, unifies; as, a natural law is a unifier of phenomena.
Example Sentences:
(1) A unified hypothesis for the neuropathologic effect of the diverse spectrum of toxic chemicals known to induce giant axonopathies is presented, based on recently published data on the structure of NF protein.
(2) 'The right-wing bloc will now be able to unify around one leader,' said Robert Misik, a senior Austrian journalist and commentator.
(3) One possibly unifying hypothesis for the obesity and pregnancy association is sustained hyperestrogenemia.
(4) Iraqi politicians started to brand themselves as cross-sectarian nationalists who wanted to build a unified Iraq.
(5) Both the in vitro and the in vivo aspects of the problem are discussed in some detail and an attemps is made to provide a reasonably unified concept for both.
(6) A unified hypothesis of lung injury in pulmonary emphysema is presented, involving both PMN and macrophage elastases and the actions of cigarette smoke.
(7) We review data that either support or reject these hypotheses and suggest a third unifying hypothesis.
(8) The contract must be acceptable to the tens of thousands of junior doctors who took unified action over the past few months to ensure patient safety and fair working conditions.
(9) Instead of unifying to demand greater access they chose to comply with the government’s demands and refusal to permit deliveries of aid, the report said.
(10) In contrast to past precedents such as the creation of Israel or Liberia, it is not obvious that “refugee” would be a sufficiently strong unifying identity to encourage disparate populations to live together.
(11) In this note is recommended a unified nomenclature for allotypes and variants of human complement factor B, which was approved by the Nomenclature Committee of the International Union of Immunological Societies (IUIS).
(12) After a historical introduction describing previous observations and views on the structure and composition of the internal limiting membrane of the retina (MLI), it is concluded that no definite unifying concept exists concerning the MLI structure.
(13) A unified approach to ligamentous instability of the lateral side of the ankle was investigated in 100 ankles of 81 patients (age range, ten to 59 years).
(14) A unifying hypothesis is proposed for the mechanism of insulin action in adipose tissue.
(15) The lack of a proven cause-and-effect relationship between mitral valve prolapse and panic disorder and the absence of a unifying mechanism do not diminish the clinical significance of the high rate of co-occurrence between the two conditions.
(16) However, in the case of the important octylphenol ethoxylates [p-C8H17-C6H4-O-(CH2CH2O)n-H], HPLC cannot resolve individual oligomers of high molecular weight Triton surfactants (e.g., greater than 2000 u or so; u = unified atomic mass unit).
(17) This paper presents a unified account of the properties of the measures, Malthusian parameter and entropy in predicting evolutionary change in populations of macromolecules, cells and individuals.
(18) Schwartz was a stickler for historical detail, which, combined with Friedman's vision of a unifying structure for tracing the effects of monetary developments on the economy, led to an entertaining work that changed our view of how the macroeconomy worked.
(19) Systematic research using such a model has shown several psychosocial factors to be associated with cancer onset and progression, and Temoshok has recently suggested a theoretical model which unifies these findings.
(20) The meeting at Tamarron illustrated the multiplicity of molecular changes found in breast cancer and concluded with the disquieting sense that, so far, there is no simple unifying molecular model to explain the etiology of the disease.