(1) In dogs, H1-receptor stimulation with 2-MeH induced pulmonary vasoconstriction, and a decrease in cardiac output.
(2) Assays were optimized for time, pH, and temperature, using trans-stilbene oxide (TSO) and cis-stilbene oxide (CSO) as substrates for cEH and mEH, respectively.
(3) PGE1, PGF2alpha and 4-methylhistamine (4-MeH: a relatively specific H2-receptor agonist) contract pulmonary arterial strips but further increase in the dose of PGE1 produces relaxation.
(4) Gathering fasting and TPN data MEH excretion was significantly related to both body (r = 0.89) and muscle (r = 0.73) NB, that were highly related to each other (r = 0.93), being muscle always worse than body NB.
(5) The reaction from Wall Street traders is more often along the lines of "meh".
(6) Thus, the hypothalamus-pituitary-adrenal axis is involved in the regulation of mEH but the regulation of the cEH enzyme remains unclear.
(7) In microsomal fractions, enzyme activities measured were pentoxyresorufin O-dealkylase (PROD), ethoxyresorufin O-dealkylase (EROD), and epoxide hydrolase (mEH).
(8) Using benzo[alpha]pyrene-4,5-oxide as substrate, mEH enzymatic activity is shown to correlate closely with tissue levels of mEH mRNA.
(9) The study demonstrates that the balance between activation of CBZ by the cytochrome P450 enzymes to a chemically reactive arene oxide metabolite and its detoxification by mEH and GSH may contribute to individual susceptibility to CBZ idiosyncratic toxicity.
(10) Thus, the pituitary appears to be important in the developmental induction of mEH but not cEH.
(11) 'Hermless, hermless, there's never nae bather fae me, I go to the library, I tak oot a book, and then I go hame for meh tea.'"
(12) Immunoblot analyses revealed that hepatic mEH levels in males increased in an age-dependent manner, with a maximal increase (approximately 3-fold) being noted at 44 weeks of age, whereas the expression of hepatic mEH in females decreased significantly at 14 weeks of age or older, by approximately 70%s, compared with that of 4-week-old rats.
(13) The possible role of the secretion from the Mehlis' gland in egg-shell formation is discussed.
(14) The excretion of the amino acid 3-methylhistidine (3-MeH), an indicator of muscle protein breakdown, and urea nitrogen loss were measured in the urine collected the day before, and on the 2nd and 4th postoperative days.
(15) Urinary excretion of urea nitrogen and 3-methylhistidine (3-MeH) after surgery was significantly lower in the warmed group compared with the cold group (P less than 0.05).
(16) These results provide evidence that the imidazole antimycotic agents induce mEH and that the mEH induction involves large increases in mRNA, with transcriptional activation.
(17) Morphological studies revealed the following major characteristics for 35 day-old worms: the mean length of the terminal segment accounted for 54% of the total worm length; the position of the sexually mature segment was always terminal; the female reproductive system possessed an elongated ovary with compact lobules; the female ducts were also compact; the Mehlis' gland was covered by the vitelline gland and the testes were distributed throughout the segment, with 1 row posterior to the vitelline gland.
(18) We have assessed the effects of glutamine (Gln) availability on protein breakdown in perfused rat hindlimb by measuring net phenylalanine (Phe) production (an index of protein balance), the dilution of [15N]Phe labelling (an index of mixed protein breakdown) and rate of production of 3-methylhistidine (3-MeH) (an index of myofibrillar breakdown).
(19) Clotrimazole, however, maintained the activated mEH transcription rate at 24 hr after treatment, exhibiting a 11-fold increase, compared with control.
(20) Immunoblot analyses revealed that administration of either ketoconazole or clotrimazole caused a approximately 4-5-fold increase in mEH levels, whereas either miconazole or econazole resulted in a approximately 7-fold increase in mEH at day 3 after treatment.
Pah
Definition:
(interj.) An exclamation expressing disgust or contempt. See Bah.
(n.) A kind of stockaded intrenchment.
Example Sentences:
(1) In contrast, Leydig cells from rat testis contain monooxygenase systems which catalyze the metabolism of PAH, such as DMBA.
(2) The reason we have postulated that one-electron oxidation plays an important role in the activation of PAH derives from certain common characteristics of the radical cation chemistry of the most potent carcinogenic PAH.
(3) It is suggested that the atmosphere of Athens favours the formation of secondary direct-acting mutagens due to the oxidation and nitration of PAH by ozone and nitrogen oxides, which are more abundant in the late spring months.
(4) The cytosol binding activity apparently decreased but reincubation of the cytosol with the radioactive ligand completely restored "4S" PAH-BP activity.
(5) PAH levels have progressively decreased in the last few decades, most probably due to the introduction of anti-smoke regulations and the decrease of coal burning for heating.
(6) The haplotype associations, relative frequencies, and distributions of five prevalent PAH mutations (R158Q, R261Q, IVS10nt546, R408W, and IVS12n1) were established in a comprehensive European sample population and subsequently were examined to determine the potential roles of several genetic mechanisms in explaining the present distribution of the major PKU alleles.
(7) The stimulation was followed by short-term hyperpolarization of primary afferents (PAH; 1-5 min) and by depression of dorsal root potentials (DPRs) which had a similar time course to the delta [K]e, and were not blocked by naloxone.
(8) An isolated rat kidney preparation was used, and the uptake of UB by renal tissue, the UB appearance in the urine, and the secretion of PAH were analyzed throughout the perfusion.
(9) The analytical method for PAH determination is based on filter extraction, two-dimensional thin-layer chromatography and fluorescence spectrometry; lead is measured by atomic absorption.
(10) Thus, the substantially invasive procedure of ureteral catheterization is not required to ascertain left and right kidney PAH clearance in patients already at risk from renal disease.
(11) Uroporphyrin, heptacarboxylic acid porphyrin, and coproporphyrin are the major porphyrins to accumulate in response to PAHs (for example, 3,3',4,4'-TCBP in chick embryo liver cell culture).
(12) We have also found useful for the determination of acceptable concentration levels for the noncarcinogenic PAHs an analogous methodology based on the relative toxicities of the noncarcinogenic PAHs.
(13) The carcinogenic potency not only of PAH-containing extracts but also of the whole exhausts has often been estimated from their benzo[a]pyrene (BP) content.
(14) Deposition fluxes of Pb, Cd, Cu and a range of 11 PAH compounds have been determined at distances of 3.8-220 m from the M6 motorway in northwest England over a period of 21 months.
(15) Sucrose-gradient analysis of BeP binding activity indicated that BeP bound with high affinity to the 4S PAH-binding protein, but not to the Ah receptor.
(16) The air was sampled daily by glass fiber's filters; a ponderal determination of total particulate was made; PAH was dosed by gas-chromatography and by mass spectrometry, metals was determined by atomic absorption spectrometry.
(17) Both the occupational and in particular the therapeutic exposure to coal tar resulted in clear increases in urinary levels of PAH metabolites as compared to unexposed subjects.
(18) Simultaneous imposition of the pH gradient (outward OH- gradient) and inward Na+ gradient stimulated PAH uptake significantly over that with an Na+ gradient alone.
(19) Using PAH as a marker for the maximal extractable perfusion flow, 1-naphthol could be regarded as a high-extraction compound even at high perfusion flow rates.
(20) Experiments with basolateral membrane vesicles prepared from rat kidney cortex were performed to study the mechanism by which p-aminohippuric acid (PAH) is taken up across the contraluminal membrane and is concentrated in proximal tubule cells.