(1) In dogs, H1-receptor stimulation with 2-MeH induced pulmonary vasoconstriction, and a decrease in cardiac output.
(2) Assays were optimized for time, pH, and temperature, using trans-stilbene oxide (TSO) and cis-stilbene oxide (CSO) as substrates for cEH and mEH, respectively.
(3) PGE1, PGF2alpha and 4-methylhistamine (4-MeH: a relatively specific H2-receptor agonist) contract pulmonary arterial strips but further increase in the dose of PGE1 produces relaxation.
(4) Gathering fasting and TPN data MEH excretion was significantly related to both body (r = 0.89) and muscle (r = 0.73) NB, that were highly related to each other (r = 0.93), being muscle always worse than body NB.
(5) The reaction from Wall Street traders is more often along the lines of "meh".
(6) Thus, the hypothalamus-pituitary-adrenal axis is involved in the regulation of mEH but the regulation of the cEH enzyme remains unclear.
(7) In microsomal fractions, enzyme activities measured were pentoxyresorufin O-dealkylase (PROD), ethoxyresorufin O-dealkylase (EROD), and epoxide hydrolase (mEH).
(8) Using benzo[alpha]pyrene-4,5-oxide as substrate, mEH enzymatic activity is shown to correlate closely with tissue levels of mEH mRNA.
(9) The study demonstrates that the balance between activation of CBZ by the cytochrome P450 enzymes to a chemically reactive arene oxide metabolite and its detoxification by mEH and GSH may contribute to individual susceptibility to CBZ idiosyncratic toxicity.
(10) Thus, the pituitary appears to be important in the developmental induction of mEH but not cEH.
(11) 'Hermless, hermless, there's never nae bather fae me, I go to the library, I tak oot a book, and then I go hame for meh tea.'"
(12) Immunoblot analyses revealed that hepatic mEH levels in males increased in an age-dependent manner, with a maximal increase (approximately 3-fold) being noted at 44 weeks of age, whereas the expression of hepatic mEH in females decreased significantly at 14 weeks of age or older, by approximately 70%s, compared with that of 4-week-old rats.
(13) The possible role of the secretion from the Mehlis' gland in egg-shell formation is discussed.
(14) The excretion of the amino acid 3-methylhistidine (3-MeH), an indicator of muscle protein breakdown, and urea nitrogen loss were measured in the urine collected the day before, and on the 2nd and 4th postoperative days.
(15) Urinary excretion of urea nitrogen and 3-methylhistidine (3-MeH) after surgery was significantly lower in the warmed group compared with the cold group (P less than 0.05).
(16) These results provide evidence that the imidazole antimycotic agents induce mEH and that the mEH induction involves large increases in mRNA, with transcriptional activation.
(17) Morphological studies revealed the following major characteristics for 35 day-old worms: the mean length of the terminal segment accounted for 54% of the total worm length; the position of the sexually mature segment was always terminal; the female reproductive system possessed an elongated ovary with compact lobules; the female ducts were also compact; the Mehlis' gland was covered by the vitelline gland and the testes were distributed throughout the segment, with 1 row posterior to the vitelline gland.
(18) We have assessed the effects of glutamine (Gln) availability on protein breakdown in perfused rat hindlimb by measuring net phenylalanine (Phe) production (an index of protein balance), the dilution of [15N]Phe labelling (an index of mixed protein breakdown) and rate of production of 3-methylhistidine (3-MeH) (an index of myofibrillar breakdown).
(19) Clotrimazole, however, maintained the activated mEH transcription rate at 24 hr after treatment, exhibiting a 11-fold increase, compared with control.
(20) Immunoblot analyses revealed that administration of either ketoconazole or clotrimazole caused a approximately 4-5-fold increase in mEH levels, whereas either miconazole or econazole resulted in a approximately 7-fold increase in mEH at day 3 after treatment.
Unenthusiastic
Definition:
Example Sentences:
(1) The advocates of reform – including the Guardian – should be unenthusiastic about endorsing a messy compromise with unintended consequences and with the prospect of years of stalemate in the courts and with the regulator itself.
(2) Low wages often mean high employee turnover and unenthusiastic workers, Flickinger said, and that can translate into poor customer service and low customer satisfaction.
(3) Weaving believes that "hard outcomes" are the best way of convincing unenthusiastic GPs that the new commissioning model works.
(4) Does it sound unenthusiastic to raise a sabbatical and postpone your start date for a year before you've even begun?
(5) Subjects listened to an audiotaped persuasive message that conveyed arguments of either high or low quality and that was responded to by either an enthusiastic or an unenthusiastic overheard audience.
(6) The EU’s environment department is unenthusiastic about the review and officials stress that they want to modernise rather than bury the conservation rules.
(7) This xenophobia mimicked a wider trend in eastern and central Europe – whose citizens were consistently the most unenthusiastic about the benefits of immigration.
(8) He is understandably unenthusiastic about going into details.
(9) It is about building bridges with all the parties in Northern Ireland James Brokenshire, Northern Ireland secretary As well as dismissing Anderson’s suggestion of an independent talks chairman, Brokenshire appeared unenthusiastic about a proposal from the Independent Unionist MP Sylvia Hermon that American diplomat Barbara Stephenson might be nominated as overseer at the discussions.
(10) The Obama administration, too, remained deeply unenthusiastic about military involvement.
(11) Not only is he unenthusiastic about Juncker, he was the biggest winner in the European elections and will hold the EU's rotating six-month presidency from 1 July.
(12) And, though it was perhaps unsurprising that Cameron should be unenthusiastic about Juncker’s candidacy, the vehemence of his opposition was extraordinary.
(13) The army, in particular, tends to be unenthusiastic, not just because it could mean more cuts in troops but because nuclear weapons are not something it can train with or ever expect to see used.
(14) Tehmina Kazi, director of British Muslims for Secular Democracy , is similarly unenthusiastic about the national debate idea.
(15) A further 37% of people were described as unenthusiastic about their online activities.
(16) The indifferent or unenthusiastic IDC (I don’t care) first appeared in 1989, while CBA (can’t be arsed) dates from 1998.
(17) The Obama administration, which has been reluctant to cast itself as anti-Wall Street, is unenthusiastic.
(18) His complaints about funding have led to reports of tensions between him and Downing Street, where aides are said to have expressed irritation in private about Stevens’ “unenthusiastic” approach to finding further savings in the NHS.
(19) The majority of the 14 general practitioners interviewed were unenthusiastic about the scheme.
(20) We turned our backs on them and many of them have either withheld their votes from us or felt disillusioned, unenthusiastic and unmotivated,” he said.